Subject(s)
Ibuprofen/analogs & derivatives , Analgesics , Animals , Antitussive Agents , Edema/prevention & control , Female , Guaiacol/analogs & derivatives , Guinea Pigs , Ibuprofen/pharmacology , Male , Mice , RatsSubject(s)
Guaiacol/analogs & derivatives , Ibuprofen/analogs & derivatives , Animals , Anti-Inflammatory Agents, Non-Steroidal , Behavior, Animal/drug effects , Digestive System/drug effects , Edema/drug therapy , Female , Fever/drug therapy , Guaiacol/therapeutic use , Guaiacol/toxicity , Ibuprofen/therapeutic use , Ibuprofen/toxicity , Lethal Dose 50 , Male , Mice , RatsABSTRACT
The serum levels of benzydamine were studied after administration by vaginal douching (at a concentration of 0.0%) to patients with and without vaginal inflammation. In both experimental groups benzydamine produced similar serum concentrations which were lower than those obtained by other administration routes, excluding the possibillity of eventual systemic effects. These data are a further confirmation that, whenever possible, topical use is preferable to systemic use in order to reduce the incidence of systemic side effects to a minimum and to obtain a more selective therapy.
Subject(s)
Benzydamine/administration & dosage , Genital Diseases, Female/drug therapy , Pyrazoles/administration & dosage , Absorption , Administration, Topical , Adult , Benzydamine/blood , Female , Humans , Time Factors , Vagina , Vaginitis/metabolismSubject(s)
Depression/drug therapy , Piperazines/therapeutic use , Trazodone/therapeutic use , Adult , Clinical Trials as Topic , Female , Humans , Male , Middle Aged , Trazodone/bloodABSTRACT
The effect of the ocular instillation of some drugs on the intraocular pressure of non-anaesthetized rabbits was studied, using the Schiötz tonometer. The risk of systemic absorption of drugs follwoing ocular instillation was evaluated by 1. measuring the spreading of effects from the treated eye to the contralateral one and 2. studying the effects on blood pressure or on blood pressure responses to noradrenaline. The results showed that trazodone, epinephrine and acetazolamide produced hypotension on the treated eye; there was no spreading of effects to the contralateral one. These data could suggest that the primary site of action of these drugs is the eye. Naphazoline reduced the intraocular pressure both on the treated eye and, with a constant delay, on the contralateral one. This was interpreted as a combination of a local action and systemic absorption. The effects of chlorpromazien were more complex. This drug produced hypertension and a strong irritation on the treated eye as well as a hypotensive effect on the contralateral one. The rise in intraocular pressure was probably caused by irritation; the hypotensive effect by systemic absorption. The following drugs were inactive: amphetamine, chlorothiazide and pilocarpine.
