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1.
J Pediatr Adolesc Gynecol ; 27(4): 227-31, 2014 Aug.
Article in English | MEDLINE | ID: mdl-24656703

ABSTRACT

STUDY OBJECTIVE: Exploring the relation between the age, time since menarche, anthropometric parameters and the growth of the uterus and ovaries in postmenarcheal girls. DESIGN: Cross sectional. SETTING: Department of Human reproduction at a tertiary pediatric referral center. PARTICIPANTS: Eight hundred thirty-five adolescent girls. INTERVENTIONS: Postmenarcheal girls were classified according to the regularity of their menstrual cycles in 2 groups (regular and irregular cycles) and compared. Anthropometric measurements and ultrasonographic examination of the pelvis was conducted with all participants. MAIN OUTCOME MEASURES: Anthropometric and ultrasonographic parameters were evaluated. RESULTS: Results of our study showed that girls with regular and irregular cycles differed in height, weight, body mass index, percentage of body fat and ovarian volumes. The size of the ovaries decreases in the group of girls with regular cycles (r = 0.14; P < .005), while it increases in girls with irregular cycles (r = 0.15; P < .001) with advancing age. Uterine volume in all patients increases gradually with age reaching consistent values at 16 years (r = 0.5; P < .001). Age at menarche, the time elapsed since menarche, the height, weight, body mass index and percentage of body fat in patients correlated with uterine volume. Ovarian volume correlated with patients' weight, BMI and percentage of fat. CONCLUSION: Uterus continues to grow in postmenarcheal years, with increasing height and weight of girls, regardless of the regularity of cycles. Postmenarcheal girls with irregular cycles were found to have heavier figures and larger ovaries.


Subject(s)
Body Composition , Menstrual Cycle/physiology , Menstruation Disturbances/physiopathology , Ovary/growth & development , Uterus/growth & development , Adiposity , Adolescent , Age Factors , Body Height , Body Mass Index , Body Weight , Child , Cross-Sectional Studies , Female , Humans , Menarche/physiology , Organ Size , Ovary/diagnostic imaging , Ultrasonography , Uterus/diagnostic imaging
2.
Med Pregl ; 60(7-8): 401-3, 2007.
Article in Serbian | MEDLINE | ID: mdl-17990810

ABSTRACT

INTRODUCTION: X-linked adrenoleukodystrophy (X-ALD) is a hereditary disorder of peroxisomal metabolism, biochemically characterized by accumulation of saturated very long chain fatty acids. DIAGNOSIS OF X-ADRENOLEUKODYSTROPHY: The biochemical diagnosis of X-linked adrenoleukodystrophy is done by gas-chromatographic analysis of plasma very long chain fatty acids. Accumulation of these fatty acids is associated with cerebral demyelination, peripheral nerve abnormalities, adrenocortical insufficiency and it may play a role in the pathogenesis of the brain inflammatory response. GENETIC COUNSELING AND PRENATAL DIAGNOSIS: Detection of familial index cases is important for diagnosis of further cases of X-ALD, treatment of asynmptomatic or barely symptomatic cases to avoid or delay symptom development of heterozygotes, and for providing genetic counseling and prenatal diagnosis in high risk persons. CONCLUSION: Retroviral mediated gene transfer corrects VLCFA metabolism in several months in cultured skin fibroblasts obtained from patients with X-ALD. Therefore, there is a hope that in the near future gene therapy may become available for those affected by this severe and potentially lethal disease.


Subject(s)
Adrenoleukodystrophy , Fatty Acids/metabolism , Adrenoleukodystrophy/diagnosis , Adrenoleukodystrophy/metabolism , Adrenoleukodystrophy/therapy , Female , Genetic Therapy , Humans , Pregnancy , Prenatal Diagnosis
3.
Srp Arh Celok Lek ; 132(7-8): 258-9, 2004.
Article in Serbian | MEDLINE | ID: mdl-15615185

ABSTRACT

Leiomyoma is the most common tumor viewed by echosonography of the uterus. This report presents pregnancy with calcified leiomyoma of the uterus which simulated the head of the fetus, what was verified by echosonography. Woman, nullipara, 41 years old, in week 21 of pregnancy, was referred for echosonographic evaluation. Biochemical screening for Down syndrome, performed in week 17 of pregnancy, was positive. Fetal karyotype, obtained by amniocentesis, was normal (46 XX). In the case presented herein, diameter of leiomyoma was 48 mm, being equal to the diameter of the fetal head in 21st week of pregnancy. Due to calcifications on the surface of leiomyoma which were viewed on echosonography in the form of hyperechogenic border, this tumor looked like a head of the fetus. This echosonographic finding of two fetal heads in a single pregnancy was remarkable even for a gynecologist experienced in echosonographic examination.


Subject(s)
Leiomyoma/diagnostic imaging , Pregnancy Complications, Neoplastic/diagnostic imaging , Ultrasonography, Prenatal , Uterine Neoplasms/diagnostic imaging , Adult , Calcinosis/diagnostic imaging , Congenital Abnormalities/diagnostic imaging , Diagnosis, Differential , Female , Humans , Pregnancy
4.
Maturitas ; 47(3): 229-34, 2004 Mar 15.
Article in English | MEDLINE | ID: mdl-15036493

ABSTRACT

OBJECTIVES: This longitudinal observational study evaluated the effect of 8 years of uninterrupted treatment of tibolone on bone mineral density (BMD) in postmenopausal women with significant osteopenia or osteoporosis. MATERIAL AND METHODS: Subjects were 66 postmenopausal women (29 with moderate or severe osteopenia and 37 with osteoporosis) who took tibolone (2.5 mg nocte) uninterruptedly for over 8 years and who attended for annual BMD assessments. Their mean age was 66.7 (0.86) years (range 50-86 years). BMD measurements at the lumbar spine and proximal femur were performed annually by dual-energy X-ray absorptiometry (DEXA). RESULTS: During the 8 years of treatment with tibolone there was a significant increase in BMD at the spine (P < 0.001) and at the hip (P < 0.001). Women who did not have previous oestrogen therapy had significantly greater response to tibolone than those who had previous treatment with conventional hormone replacement therapy (HRT). CONCLUSION: This long-term observational study provides evidence of the effectiveness of tibolone in postmenopausal women with moderate/severe osteopenia and osteoporosis in terms of a significant increase in BMD.


Subject(s)
Bone Density/drug effects , Bone Diseases, Metabolic/drug therapy , Estrogen Receptor Modulators/therapeutic use , Norpregnenes/therapeutic use , Osteoporosis, Postmenopausal/drug therapy , Absorptiometry, Photon , Aged , Aged, 80 and over , Calcium, Dietary/administration & dosage , Cohort Studies , Estrogen Receptor Modulators/pharmacology , Female , Follow-Up Studies , Humans , Longitudinal Studies , Middle Aged , Norpregnenes/pharmacology , Postmenopause , Prospective Studies , Treatment Outcome
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