[Results of immunization with allogenic leukocytes in women with recurrent pregnancy loss].

Immunization with allogenic leukocytes has been proposed as immunotherapy of recurrent pregnancy loss. However efficacy, mechanism and immune monitoring of it remain not fully explainable. Our results suggest high clinical efficacy of alloimmunization related to normalizing effect on subsets, activation and suppressor function of lymphocytes, and placental protein production. Based on data obtained, the possible use of immune parameters and placental proteins for determination of alloimmunization efficacy was proposed.