ABSTRACT
With the global incidence of non-small cell lung cancer (NSCLC) on the rise, the development of innovative treatment strategies is increasingly vital. This review underscores the pivotal role of precision medicine in transforming NSCLC management, particularly through the integration of genomic and epigenomic insights to enhance treatment outcomes for patients. We focus on the identification of key gene mutations and examine the evolution and impact of targeted therapies. These therapies have shown encouraging results in improving survival rates and quality of life. Despite numerous gene mutations being identified in association with NSCLC, targeted treatments are available for only a select few. This paper offers an exhaustive analysis of the pathogenesis of NSCLC and reviews the latest advancements in targeted therapeutic approaches. It emphasizes the ongoing necessity for research and development in this domain. In addition, we discuss the current challenges faced in the clinical application of these therapies and the potential directions for future research, including the identification of novel targets and the development of new treatment modalities.
Subject(s)
Carcinoma, Non-Small-Cell Lung , Lung Neoplasms , Molecular Targeted Therapy , Humans , Carcinoma, Non-Small-Cell Lung/genetics , Carcinoma, Non-Small-Cell Lung/therapy , Carcinoma, Non-Small-Cell Lung/drug therapy , Carcinoma, Non-Small-Cell Lung/pathology , Lung Neoplasms/genetics , Lung Neoplasms/therapy , Lung Neoplasms/drug therapy , Lung Neoplasms/pathology , Molecular Targeted Therapy/methods , Precision Medicine , MutationABSTRACT
The influence of rare earth element (RE) Y on the microstructure and corrosion behavior of extruded AZ91 Mg alloy was surveyed via morphology characterization and corrosion performance measurements. The results indicate the corrosion resistance of the transversal section of AZ91 Mg alloy containing Y was improved compared with AZ91 Mg alloy without Y. The corrosion resistance of the longitudinal section of AZ91 Mg alloy with Y was lower than that of AZ91 Mg alloy without Y. The change of corrosion resistance can be attributed to the dispersion and volume fraction of the second phase, the effect of cathodic reduction rate, and the refined second phase.
ABSTRACT
One specimen was collected from the main course of Lancangjiang River (upper reach of Mekong) in Guanlei Port, Xishuangbanna, Yunnan, China in April, 2008. It is identified as Dasyatis laosensis, a new record of Dasyatidae species in China. It could be distinguished from other Dasyatis species by a combination of the following characteristics: one enlarged venomous spine on the tail, ventral surface of body with orange marginal coloration, tail length greater than body length.
Subject(s)
Skates, Fish/classification , Animals , China , Ecosystem , Skates, Fish/anatomy & histologyABSTRACT
One specimen was collected from Lancangjiang River in Jinghong, China on August 1st, 2006. It is identified as Anguilla bicolor McClelland, 1844, a new record of Anguillidae species occurring in Lancangjiang River in China. It could be distinguished from other Anguilla species by the character as: dorsal-fin origin located above vent vertically. It is an active nocturnal forager, feeding largely on a diet of crustaceans and mollusks.
