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1.
J Asian Nat Prod Res ; 24(9): 884-890, 2022 Sep.
Article in English | MEDLINE | ID: mdl-34647831

ABSTRACT

A new ent-kaurane diterpenoid, named kaurane daturoside A (1), was isolated from the 70%-EtOH extract of dried pericarps of Datura metel L., along with six known terpenoids, 16α,17-dihydroxy-ent-kauran-19-diglycoside (2), cyclosieversioside F (3), astragaloside II (4), ginsenoside Rg1 (5), astrojanoside A (6), celerioside E (7). The isolated structures were elucidated by means of spectroscopic analyses, and the compounds 2, 3, 7 were separated from Solanaceae for the first time. Meanwhile, among isolates, compounds 2 and 5 exhibited anti-inflammatory activities against LPS-activated RAW264.7 cells (IC50<11.00 µM).


Subject(s)
Datura metel , Diterpenes, Kaurane , Diterpenes , Anti-Inflammatory Agents/chemistry , Anti-Inflammatory Agents/pharmacology , Datura metel/chemistry , Diterpenes/chemistry , Diterpenes, Kaurane/chemistry , Diterpenes, Kaurane/pharmacology , Lipopolysaccharides/pharmacology , Molecular Structure , Plant Extracts/chemistry
2.
Steroids ; 173: 108877, 2021 09.
Article in English | MEDLINE | ID: mdl-34133956

ABSTRACT

Extraction of Datura metel L. leaves with ethanol as a solvent gave a group of steroids, including two unique 1,10-seco-withanolides (1, 4), an unusual nitrogen-containing withanolides (2), one undescribed saponin (3), two withanolides with a carbohydrate (5, 6), and one C21 steroid (7). These compounds' structures were identified based on HR-ESI-MS and 1H, 13C NMR data analyses, also compared with data from the document. Some compounds showed moderate inhibition on NO production in lipopolysaccharide-stimulated RAW 264.7 cells.


Subject(s)
Datura metel/chemistry , Phytosterols/chemistry , Plant Leaves/chemistry
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