Ultra-rapid and highly selective colorimetric detection of hydrochloric acid via an aggregation to dispersion change of gold nanoparticles.

A rapid and highly selective naked-eye detection of hydrochloric acid (HCl) in an aqueous medium was established using HCl-triggered redispersion of gold nanoparticle aggregates.

Carbon Quantum Dots Derived from Herbal Medicine as Therapeutic Nanoagents for Rheumatoid Arthritis with Ultrahigh Lubrication and Anti-inflammation.

As a typical chronic inflammatory joint disease with swelling and pain syndromes, rheumatoid arthritis (RA) is closely related to articular lubrication deficiency and excessive proinflammatory cytokines in its progression and pathogenesis. Herein, inspired by the dual effects of joint lubrication improvement and anti-inflammation to treat RA, two novel potential therapeutic nanoagents have been developed rationally by employing herbal medicine-derived carbon quantum dots (CQDs), i.e., safflower (Carthamus tinctorius L.) CQDs and Angelica sinensis CQDs, yielding ultrahigh lubrication and anti-inflammation bioefficacy. In vitro experimental results show that the two nanoagents display excellent friction reduction due to their good water solubility and spherical structure. Using RA rat models, it is indicated that the nanoagents significantly relieved swelling symptoms and inhibited the expression of related inflammatory cytokines, including IL-1, IL-6, and TNF-α, indicating their extraordinary anti-inflammation bioefficacy. Thus, combining the lubricating and anti-inflammation bioefficacy of CQDs derived from herbal medicine is an attractive strategy to develop new nanoagents for RA treatment.

Highly selective adsorption of rare earth elements by honeycomb-shaped covalent organic frameworks synthesized in deep eutectic solvents.

One of the key factors to obtain a highly pure individual rare earth element (REE) is to prepare adsorbents with high selectivity and adsorption capacity. Covalent organic frameworks (COFs), which encompass a variety of properties, including regular/tunable pore size, high specific surface area and easy functionalization, could be effective as adsorbents for separating rare earth elements (REEs). In this paper, TpPa COFs were successfully synthesized using an eco-friendly deep eutectic solvent (DES) as the reaction medium instead of toxic organic solvents at room temperature. TpPa COFs have a good separation effect on the nine REEs investigated in this work. Among them, the separation factors (ß) of Eu/Yb, Eu/Tm and Eu/La are 15.34, 14.70 and 10.78, respectively, indicating that the TpPa COFs have good separation performance. Further discoveries showed that the adsorption and separation mechanism of the TpPa COFs for REEs in this experiment may be due to the coordination of REE ions with O to form a stable structure. This study blazed a trial for a green and facile synthesis strategy of TpPa COFs and expanded its implementation as a solid adsorbent in the separation of REEs.