ABSTRACT
AIMS: Atrial fibrillation is the most common heart disease. Previous research has found that several members of the matrix metalloproteinase (MMP) family are involved. However, the role of the most recently discovered member of the MMP family, MMP-28, has not been fully investigated. The present study aimed to reveal the role of MMP-28 in atrial fibrillation. MAIN METHODS: 254 patients with sinus rhythm, paroxysmal atrial fibrillation, or persistent atrial fibrillation were enrolled in this prospective observational study. Circulating MMP-28, echocardiography, and other clinical variables were measured at hospital admission. Patients were followed for up to 7â¯months, and the end-point was occurrence of heart failure. KEY FINDINGS: MMP-28 was significantly higher in patients with atrial fibrillation than with sinus rhythm, and MMP-28 level was correlated with left atrial diameter. Additionally, MMP-28 independently predicted follow-up heart failure. Other clinical risk factors were previous myocardial infarction, brain natriuretic peptide, persistent atrial fibrillation, and left atrial diameter. MMP-28 increased the performance of prognostic prediction of heart failure. SIGNIFICANCE: Circulating MMP-28 was elevated in atrial fibrillation. MMP-28 may be related to atrial fibrillation and heart failure.
Subject(s)
Atrial Fibrillation/enzymology , Atrial Fibrillation/physiopathology , Matrix Metalloproteinases, Secreted/metabolism , Aged , Atrial Fibrillation/diagnostic imaging , Atrial Function, Left , Echocardiography , Endpoint Determination , Female , Heart Atria/pathology , Heart Failure/etiology , Heart Failure/physiopathology , Humans , Kaplan-Meier Estimate , Male , Middle Aged , Predictive Value of Tests , Prospective Studies , Survival AnalysisABSTRACT
Objective To explore the diagnosis and treatment of poorly differentiated endocardial sarcoma. Method The clinical data of a child with poorly differentiated endocardial sarcoma was retrospectively analyzed. Results One-year-old girl was admitted for diarrhea, polypnea, cyanosis, and cough. Abnormal heart sound was found by auscultation. Leads Ⅱ, Ⅲ, and aVF of ECG showed high peaked P wave. The diagnosis of poorly differentiated endocardial sarcoma was confirmed by echocardiography and pathology after cardiac operation. Three months after discharge from the hospital, the patient suddenly came into coma and died. Conclusion The diagnosis of poorly differentiated endocardial sarcoma is mainly based on clinical manifestations, echocardiography and pathology. Surgical resection is the first choice and chemotherapy and radiotherapy play a supporting role. However, there is no cure for it currently.
