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Org Biomol Chem
; 22(18): 3592-3596, 2024 May 08.
Article
in English
| MEDLINE
| ID: mdl-38624160
ABSTRACT
Herein, we describe an efficient method for the synthesis of alkenylphosphine oxides via a Tf2O promoted addition-elimination process. Various diarylphosphine oxides and alkylarylphosphine oxides react with ketones smoothly and produce alkenylphosphine oxides in moderate to excellent yields with abundant functional group compatibility. In addition, several transformations and applications of the product also demonstrate the potential value of the methodology.