ABSTRACT
Hospital-acquired pressure ulcers (HAPUs) are still an important worldwide issue related to the safety and quality of patient care, which are among the top five adverse events reported. Patients who develop HAPUs have longer stays in the hospital than necessary, are at a greater risk of infections, and are more likely to die. Surgical patients are prone to developing PUs because they often remain immobile for extended periods of time, and their surgical procedures may limit the flow of blood oxygen and nutrition and lead to a decrease in muscle tone. Mesenchymal stem cells (MSCs) represent an attractive stem cell source for tissue regeneration in clinical applications, which have been demonstrated to improve wound healing through re-epithelialization, increased angiogenesis, and granulation tissue formation. Here, we present the case of an emergency surgical patient who developed an ulcer on the right heel during hospitalization. The human umbilical cord Wharton's jelly-derived MSCs (WJ-MSCs) re-suspended in platelet-rich plasma (PRP) were injected into ulcer margins. Four days after the WJ-MSC application, the patient showed progressive healing of the PU. From days 4 to 33, granulation tissue formation and re-epithelialization were clearly observed. The ulcer was almost healed completely on day 47, and the pain in the patient's wound area also decreased. Thus, intradermal transplantation of WJ-MSCs and PRP was safe and effective for treatment in patients with pressure ulcers. WJ-MSCs, together with PRP, may offer a promising treatment option for wound healing.
ABSTRACT
The aim of the study was to investigate the application of hydrocolloid dressings in the prevention and treatment of infant diaper rash. A total of 210 infants with diaper rash were included in the study and randomized into 3 groups of 70 infants. Infants in group A received hydrocolloid dressings and individualized nursing; infants in group B received mupirocin plaster and topical application of pearl powder as well as routine nursing; and infants in group C received zinc oxide plaster and routine nursing. The clinical efficacy, incidence of adverse events, time to resolution of diaper rash, hospitalization duration, mean cost and satisfaction of nursing were compared between the 3 groups. After 1 cycle of treatment and nursing, the difference in the healing rate of mild diaper rash between groups A, B and C was significant (P<0.05), with the best healing rate in group A. Differences in the healing rate of grade I and II diaper rash between groups A, B and C was significant (P<0.05), with the best healing rate in group A. The incidence of adverse events in infants between groups A, B and C were significantly different (P<0.05), with the lowest incidence in group A (2.9%). The time to resolution of diaper rash, hospitalization duration and cost in infants were not significantly different (P<0.05). The satisfaction rate of nursing for the parents of groups A, B and C was 98.6, 87.1 and 80.0%, respectively (P<0.05). Hydrocolloid dressings combined with individualized nursing may prevent and treat infant diaper rash effectively, decrease the incidence of adverse reactions significantly, shorten time to resolution of diaper rash and hospitalization duration, reduce mean hospitalization cost, improve parent satisfaction and promote nursing-patient harmony. Thus, this method of treatment was worthy of clinical application.
ABSTRACT
The absorption properties of zinc-nickel alloy electrolyte were studied by visible spectrophotometer. The results show that the relationship between the absorbance of the zinc-nickel alloy electrolyte and Ni(2+) concentration in the electrolyte obeys Beer's law at 660 nm. In addition, other components except Ni(2+) in the zinc-nickel alloy electrolyte such as zinc chloride, ammonium chloride, potassium chloride and boric acid have no obvious effect on the absorbance of zinc-nickel alloy electrolyte. Based on these properties, a new method is developed to determine Ni(2+) concentration in zinc-nickel alloy electrolyte. Comparing with other methods, this method is simple, direct and accurate. Moreover, the whole testing process does not consume any reagent and dilution, and after testing, the electrolyte samples can be reused without any pollution to the environment.
