A study of the mediating effect of social support on self-disclosure and demoralization in Chinese older adult homebound breast cancer patients.

Purpose: Demoralization is common in older adult homebound breast cancer patients, seriously affecting their quality of life. This study aimed to investigate the demoralization of older adult homebound breast cancer patients and to analyse the mediating effects of social support between self-disclosure and demoralization. Methods: The study enrolled 368 older adult homebound breast cancer patients reviewed in outpatient clinics of three hospitals from January 2022 to August 2023. A questionnaire survey was conducted using the general information questionnaire, the distress disclosure index (DDI), the social support revalued scale (SSRS), and the demoralization scale (DS). Path analysis was conducted to test the hypothesised serial mediation model. Results: The total scores of self-disclosure, social support, and demoralization were 37 (25-42), 34 (19-48.75), and 46.5 (35-68), respectively. The results indicated a positive correlation between self-disclosure and social support (p < 0.01). In contrast, a statistically significant negative correlation was observed between self-disclosure, social support, and various demoralization dimensions (p < 0.01). Social support played a partial mediation effects between self-disclosure and demoralization, indirect effect =0.6362, SE = -0.591, 95% CI (-0.785 ~ -0.415); Self-disclosure direct effect demoralization, direct effect =0.3638, SE = -0.337, 95% CI (-0.525 ~ -0.144); total effect, SE = -0.929, 95% CI (-0.945 ~ -0.904). Discussion: Social support a partial mediated between self-disclosure and demoralization in Chinese older adult homebound breast cancer patients. Clinical staff should focus on developing a social support system for Chinese older adult homebound breast cancer patients, encouraging patients to reveal their minds, and providing psychological counselling to enhance self-confidence and rebirth from adversity.

The mediating role of self-efficacy of managing chronic disease between the dual-mode of self-control and the fatigue in breast cancer patients undergoing postoperative chemotherapy.

Background: Fatigue is prevalent in breast cancer patients undergoing postoperative chemotherapy, which seriously affects physical and mental health. The present study aimed to investigate the relevance of fatigue, the self-efficacy of managing chronic disease (SEMCD), and the dual-mode of self-control (DMSC) in patients. Methods: Three hundred and seventy six breast cancer patients undergoing postoperative chemotherapy participated in this cross-sectional study. The General Information Questionnaire, Fatigue Scale-14 (FS-14), SEMCD-Scale (SEMCD-S), and DMSC-Scale (DMSC-S) were utilized to survey. Pearson correlation analysis and structural equation modeling were used for the statistical analysis of the correlation between the variables and mediating effects. Results: A total of 372 valid questionnaires (98.94%) were returned. The total fatigue score of FS-14 was (10.84 ± 1.80), the SEMCD-S score (30.05 ± 15.18), and the DMSC-Scale score (73.35 ± 9.49). Furthermore, physical fatigue was negatively correlated with the SEMCD-S and problem solving (r = -0.764 ~ -0.680, P < 0.01). Mental fatigue correlated positively with poor delay of gratification (r = 0.134, P < 0.05), and the SEMCD-S was also negatively correlated with the impulsivity, distractibility, and poor delay of gratification dimensions (r =-0.229~-0.130, P < 0.05). SEMCD correlated positively with problem-solving and future time perspective (r = 0.695~0.790, P < 0.001). In addition, SEMCD partially mediated the effect between the DMSC and fatigue (ß = -0.335, P < 0.01), with the mediating effect accounting for 51.25%. Conclusion: Through SEMCD measure, it was found that DMSC indirectly influences fatigue levels in breast cancer patients undergoing postoperative chemotherapy.

RETRACTED: Physcion 8-O-ß-glucopyranoside inhibits clear-cell renal cell carcinoma bydownregulating hexokinase II and inhibiting glycolysis.

This article has been retracted: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy). This article has been retracted at the request of the Editor-in-Chief and the authors. Panels from Figure 2A appear similar to panels from Figure 3A of the article published by Xiangyang Dou, Meihua Wang, Tao Zhang and Jiapei Yao in The Anatomical Record (2019) https://doi.org/10.1002/ar.24324, Figures 2B and 6B of the article published by C.-L. Xue, H.-G. Liu, B.-Y. Li, S.-H. He and Q.-F. Yue in the Eur. Rev. Med. Pharmacol. Sci. 23 (2019) 5101-5112 https://doi.org/10.26355/eurrev_201906_18174 and Figure 3B of the article published by Bo Liu and Shuo Yu in Biomedicine & Pharmacotherapy 107 (2018) 243-253 https://doi.org/10.1016/j.biopha.2018.07.177. Panels from Figure 6D appear similar to panels from Figure 8D of the article published by The Anatomical Record (2019) https://doi.org/10.1002/ar.24324, Figure 7E of the article published by Ying Niu, Jinping Zhang, Yalin Tong, Jiansheng Li and Bingrong Liu in Life Sciences 237 (2019) 116893 https://doi.org/10.1016/j.lfs.2019.116893 and Figure 7F of the article published by Xiaoping Pan, Chen Wang, Yan Li, Lida Zhu and Ti Zhang in Life Sciences 214 (2018) 124-135 https://doi.org/10.1016/j.lfs.2018.10.064. Although this article was published earlier than the other articles, the Editor decided to retract this article given concerns about the reliability of the data.

Physcion 8-O-ß-glucopyranoside induces apoptosis, suppresses invasion and inhibits epithelial to mesenchymal transition of hepatocellular carcinoma HepG2 cells.

BACKGROUND: Aberrant increased expression of DNMT1 and resulting silence of tumor suppressor genes have been found in a variety of human malignancies and DNMT1 has been considered as a promising therapeutic target for cancer prevention and treatment. One of the main active ingredients of Rumex japonicus Houtt, physcion 8-O-ß-glucopyranoside (PG), has been found to have antitumor activities. MATERIALS AND METHODS: Human hepatocellular carcinoma (HCC) cell line HepG2 was examined. Cell proliferation was analyzed using MTT assay. The apoptosis, migration and invasion were determined by flow cytometry, wound healing and Transwell assay, respectively. The expression of signaling molecules were examined by RT-PCR and western blots. RESULTS: Our results provide experimental evidence that PG inhibits growth and suppresses invasion of HCC cells by downregulating DNMT1 via ROS-dependent AMP-activated protein kinase (AMPK)-mediated modulation of transcription factor Sp1. CONCLUSION: our results revealed for the first time that PG inhibits growth and suppresses invasion of HCC, highlighting the anti-tumor activities of PG against HCC. However, further studies, including clinical trials, are needed to fully evaluate PG as a novel therapeutic in cancer prevention and treatment.