ABSTRACT
OBJECTIVE: To investigate the effect of Sanwu hypotensive decoction (SWHD) on blood pressure (BP) and lymphokine activated killer cell (LAK) and possible mechanism. METHODS: Thirty mild hypertension patients were treated with SWHD for 8 weeks, the levels of BP, proliferative ability and activity of LAK cell, SOD-like substance expressed by LAK cell and its radical scavenger ability before and after treatment were observed using randomized, single blinded, self-control, paralled assay, and compared with other 30 patients treated with captopril for control. In an experimental study, the vasodilatory response of thoracic aortic ring to acetylcholine and nitroglycerine, and effect of LAK cell, standard reagent of SOD, SWHD on the response were observed and compared in spontaneously hypertensive rats (SHR) and Wistar Kyoto rats (WKR). RESULTS: After SWHD treatment, along with lowering of BP, the proliferative ability, activity SOD-like substance expressed by LAK cell and its radical scavenger ability increased significantly. CONCLUSION: SWHD is not only an effective hypotensive agent, but also an immunoregulator.
Subject(s)
Antihypertensive Agents/therapeutic use , Drugs, Chinese Herbal/therapeutic use , Hypertension/drug therapy , Phytotherapy , Animals , Female , Humans , Hypertension/immunology , Killer Cells, Lymphokine-Activated/immunology , Male , Middle Aged , Rats , Rats, Inbred SHR , Rats, Inbred WKY , Single-Blind MethodABSTRACT
OBJECTIVE: To investigate the effect of total saponins of Panax Notoginseng (TSPNS) on left ventricular diastolic function in patients with essential hypertension (EH) and possible mechanism. METHODS: Left ventricular diastolic function (peak E, peak A, E/A, A area fraction, E area fraction), left ventricular muscle mass index (LV-MI), intraerythrocytic calcium and calcium pump activity on erythrocytes membrance of 30 patients with EH before and after the combined treatment of captopril and TSPNS were measured. Captopril was used singly on 30 patients above mentioned that were also studied as self-control. Observation of TSPNS and normal saline was used on a matched control in treating SHR rats. WKY rats of similar age were also studied as normal control. RESULTS: Left ventricular diastolic function were improved markedly by TSPNS. The activity of calcium pump on membrance of sarcoplasmic reticulum were increased and the myocardial intracellular calcium were decreased and the left ventricular muscle mass were reduced after treatment of TSPNS. The calcium and calcium pump of erythrocyte showed marked simple correlation with myocardial cell. CONCLUSIONS: The TSPNS could improve myocardial relaxation function due to enhancing calcium pump activity and inhibiting intracellular calcium overload and lightening left ventricular muscle mass.
Subject(s)
Calcium-Transporting ATPases/metabolism , Saponins/pharmacology , Ventricular Function, Left/drug effects , Aged , Aged, 80 and over , Animals , Calcium/metabolism , Erythrocyte Membrane/enzymology , Erythrocytes/metabolism , Female , Ginsenosides , Humans , Hypertension/physiopathology , Male , Middle Aged , Panax/chemistry , Plants, Medicinal , Rats , Rats, Inbred SHR , Rats, Inbred WKY , Saponins/isolation & purificationABSTRACT
The efficacy of Astragalus membranaceus (AM) oral liquor combined with routine therapy and routine therapy alone on T-lymphocyte subsets of peripheral blood in viral myocarditis patients have been studied. The results showed that the T-lymphocyte subsets profile and OKT4/OKT8 ratio of peripheral blood were significantly lower in viral myocarditis patients than that in healthy control (P < 0.05, 0.01). Routine therapy combined with AM could significantly enhance OKT3, OKT4 and OKT4/OKT8 ratio in the above-mentioned patients (P < 0.05, 0.01). The possible pharmacodynamic mechanism of improved cell immunity in viral myocarditis patients by combining routine therapy with AM was discussed.
