The Role of Acupuncture Improving Cognitive Deficits due to Alzheimer's Disease or Vascular Diseases through Regulating Neuroplasticity.

Dementia affects millions of elderly worldwide causing remarkable costs to society, but effective treatment is still lacking. Acupuncture is one of the complementary therapies that has been applied to cognitive deficits such as Alzheimer's disease (AD) and vascular cognitive impairment (VCI), while the underlying mechanisms of its therapeutic efficiency remain elusive. Neuroplasticity is defined as the ability of the nervous system to adapt to internal and external environmental changes, which may support some data to clarify mechanisms how acupuncture improves cognitive impairments. This review summarizes the up-to-date and comprehensive information on the effectiveness of acupuncture treatment on neurogenesis and gliogenesis, synaptic plasticity, related regulatory factors, and signaling pathways, as well as brain network connectivity, to lay ground for fully elucidating the potential mechanism of acupuncture on the regulation of neuroplasticity and promoting its clinical application as a complementary therapy for AD and VCI.

[Effect of electroacupuncture intervention at different phases of post-operation on bladder function in patients undergoing cervical cancer operation].

OBJECTIVE: To observe the effect of electroacupuncture (EA) at different time-points after cervical carcinoma surgery on urinary bladder function of uroschesis patients so as to determine the optimum time of acupuncture intervention. METHODS: Sixty cervical cancer post-operation patients with catheter due to uroschesis were randomly and equally divided into late treatment group (acupuncture intervention was given from the over 15th day on after surgery) and early treatment group (acupuncture was given from the 7th day to the 14th day after surgery). Bilateral Shangliao (BL 31), Ciliao (BL 32), Zhongliao (BL 33), Xialiao (BL 34), Zhibian (BL 54), Yinlingquan (SP 9) and Sanyinjiao (SP 6) were punctured with filiform needles combined with electrical stimulation of bilateral BL 31 and BL 34 for 30 min, once daily for 10 sessions. The residual urine volume was measured before treatment and after 5 and 10 sessions of treatment separately. RESULTS: After 5 and 10 sessions of treatment, the average residual urine volumes of both late treatment and early treatment groups were decreased significantly ( P< 0.05), and the residual urine volume level of the early treatment group was markedly lower than that of the late treatment group (P < 0.05). After 5 sessions of acupuncture treatment, of the two 30 cases in the late treatment and early treatment groups, 8 and 17 had an automatic micturition, 22 and 13 needed catheter retention, and following 10 sessions of treatment, 22 and 27 had an automatic micturition, and 8 and 3 still needed catheter retention, respectively. Regarding the functional recovery state of the urinary bladder, of the two 30 cases in the late treatment and early treatment groups, 6 and 14 were good, 24 and 16 poor respectively following 5 sessions of treatment; 15 and 22 were good, 15 and 8 were poor respectively following 10 sessions of treatment. The therapeutic effects of the early treatment group were apparently superior to those of the late treatment group. The number of the treatment sessions for recovering the bladder function was obviously fewer in the early treatment group than in the late treatment group (P < 0.05). CONCLUSION: Early acupuncture intervention is significantly better than late treatment for reducing residual urine volume and promoting bladder function recovery for uroschesis patients undergoing cervical cancer operation.

[Effect of acupotomy lysis on serum matrix metalloproteinase (MMP)-3 and MMP-13 contents in osteoarthritis rabbits].

OBJECTIVE: To observe the effect of acupotomy lysis on serum matrix metalloproteinase (MMP)-3 and MMP-13 contents in osteoarthritis (OA) rabbits. METHODS: A total of 34 New Zealand rabbits were randomly divided into normal group (n = 7), model group (n = 7), acupotomy group (n = 10) and electroacupuncture (EA) group (n = 10). OA model was established by left-hindlimb-joint-immobilization method. Acupotomy lysis was applied to the affected joint, once a week for 3 weeks. EA (2/100 Hz, 2 mA) was applied to "Yinlingquan" (SP 9), "Yanglingquan" (GB 34) and "Liangqiu" (ST 34) on the left hindlimb for 10 min, 3 times a week for 3 weeks. Serum MMP-3 and MMP-13 contents were detected with enzyme linked immunosorbent assay (ELISA) method. RESULTS: In comparison with model group (grade III: 1 case; grade: 4 cases), the left knee-joint-motion range of rabbits in acupotomy and EA groups (grade I: 1 and 1 case; grade II: 4 and 3 cases; grade III: 2 and 2 cases; grade IV: 1 and 2 cases separately) increased significantly (P < 0.05). Compared with normal group, serum MMP-3 and MMP-13 contents in model group increased significantly (P < 0.05); while compared with model group, both MMP-3 and MMP-13 levels of acupotomy and EA groups reduced considerably (P < 0.05). No obvious difference was found between acupotomy and EA groups in the left knee-joint motion range, and serum MMP-3 and MMP-13 levels (P > 0.05). CONCLUSION: Acupotomy is effective in lowering serum MMP-3 and MMP-13 levels, and in improving OA rabbits' knee-joint motion range.

[Advances of studies on acupuncture reinforcing-reducing of twirling-rotating the needle].

The theories and clinical and experimental studies about reinforcing-reducing manipulation of twirling rotating the needle in recent 15 years are reviewed and a brief account of manipulation methods, mechanisms and effects of reinforcing-reducing manipulation of twirling-rotating the needle is given, and it is indicated that the following several aspects in the studies at present need to be completed. Standardization and establishment of national standard of acupuncture manipulation must be enforced; quantitative parameters of acupuncture manipulation and mechanisms of acupuncture reinforcing-reducing of twirling-rotating the needle need to be further studied.