[Diagnosis and treatment of 18 cases of Chiari malformation with hoarseness].

Objective: To investigate the diagnosis and treatment of Chiari malformation patients with hoarseness and other otorhinolaryngological symptoms. Methods: The clinical data of 18 patients of Chiari malformation with hoarseness were retrospectively collected, which was composed of 5 men and 13 women, aged 3-71 with median age of 52. All the patients were admitted to the Affiliated Hospital of Qingdao University from January 1989 to January 2020. All patients underwent brain MRI and laryngoscopy. The patient's symptoms and first diagnosis department, diagnosis time, total course of disease, hoarseness course, diagnosis and treatment, and postoperative recovery time were summarized. Follow-up time was 3-16 years, with median follow-up time of 6.5 years. Descriptive methods were used for analysis. Results: The first visit departments of 18 patients included neurology (9 cases), otorhinolaryngology head and neck surgery (5 cases), pediatrics (2 cases), orthopedics (1 case) and respiratory department (1 case). Except for the 7 cases in neurology department, the other 11 patients were not diagnosed in time. The disease duration of 18 patients with Chiari malformation ranged from 2 months to 5 years, and hoarseness was present from 20 days to 5 years. After diagnosis, 9 patients underwent posterior fossa decompression surgery, and 1 of them underwent syrinx drainage at the same time. The symptoms of 8 cases improved significantly after operation, with the improvement time from 1 to 30 days. In addition, 9 patients chose conservative treatment, among whom 8 had no improvement in symptoms and 6 progressed. Conclusions: Posterior fossa decompression is an effective treatment for Chiari malformation, and the prognosis is good. Timely diagnosis and treatment can improve the prognosis of patients.

[Clinical analysis of orbital complications due to rhinosinusitis in 28 cases].

Objective: To investigate the clinical characteristics of orbital complications due to rhinosinusitis and to provide the basis for the diagnosis and treatment of this disease. Methods: Retrospectively analyzed the clinical data of 28 patients with orbital complications due to rhinosinusitis who were admitted into the Affiliated Hospital of Qingdao University, Department of Otorhinolaryngology from August 2009 to April 2017. In all 28 cases, there were 1 case with preseptal cellulites, 9 cases with orbital cellulites, 13 cases with subperiosteal orbital abscess and 5 cases with orbital abscess. Among all the patients, 9 were younger than 14. Two patients were in ages from 14 to 17 and 7 patients were at or above 18 years. Absolute medicine therapy was performed on 8 patients and combined therapy of operation and pharmacotherapy on 20 patients. Results: The patients were followed up for 2 to 19 months. Both the general symptoms and ocular symptoms disappeared and nasal ventilation function recovered well. Conclusions: The treatment for orbital complications of rhinosinusitis includes absolute medicine therapy and combined therapy of operation and pharmacotherapy. And the selection of treatment depends on disease stage. Timely diagnosis and reasonable treatment would be beneficial in the recovery of patients.

Eimeria tenella infection induces recrudescence of previous Salmonella enteritidis infection in chickens.

Four experiments were conducted to examine the effect of Eimeria tenella infection on the recrudescence of Salmonella enteritidis in previously infected chickens. Significant recrudescence of cecal colonization in the birds challenged with E. tenella was observed at 3 wk after S. enteritidis infection in Experiment 1, at 3 and 4 wk in Experiment 2, and at 3, 4, and 5 wk in Experiments 3 and 4. The recrudescence was indicated by .81 to 6.31 logs increase in cecal S. enteritidis counts and by higher percentages of ceca that were culture-positive. The possible prolonged cecal S. enteritidis shedding from chickens infected with coccidia into the environment might be important for the perpetuation of S. enteritidis infectious cycle. Except for Experiment 1, in which a significant higher culture-positive rate of the liver was detected in the coccidia-infected group, no significant difference of culture-positive rate of liver and spleen between the treatments was observed. The recrudescence of previous S. enteritidis infection caused by E. tenella infection was obviously related to the initial S. enteritidis dose size and time of exposure to coccidia.

Effect of lactose and Lactobacillus acidophilus on the colonization of Salmonella enteritidis in chicks concurrently infected with Eimeria tenella.

The effect of dietary lactose and Lactobacillus acidophilus on the colonization of Salmonella enteritidis (phage type 4) in newly hatched leghorn chicks concurrently infected with Eimeria tenella was studied. There were six groups of birds in each of two replicate trials: uninfected controls, birds infected with S. enteritidis, birds infected with S. enteritidis and E. tenella, birds infected with S. enteritidis and E. tenella that were fed with dietary lactose (5%), birds infected with S. enteritidis and E. tenella that were provided with L. acidophilus, and birds infected with S. enteritidis and E. tenella that were fed both L. acidophilus and dietary lactose (5%). Chickens were necropsied at 2, 5, and 8 days after S. enteritidis inoculation for bacteriological examination. The cecal population of S. enteritidis was significantly increased by infection with E. tenella. Lactose alone and the combination of lactose and L. acidophilus significantly reduced the population of S. enteritidis in the ceca of birds infected with E. tenella (P < 0.05), but the combination was more effective than lactose alone (P < 0.05). Adding anaerobic culture of L. acidophilus alone did not significantly decrease the population of S. enteritidis in the ceca. No significant reduction of colonization of S. enteritidis in the liver and spleen of birds with coccidiosis was observed.

Effect of Eimeria tenella infection on Salmonella enteritidis infection in chickens.

The effect of Eimeria tenella infection on the Salmonella enteritidis infection in chickens was investigated in three experiments. Each experiment consisted of an uninfected control, birds infected with E. tenella, birds infected with S. enteritidis, and birds infected with a combination of E. tenella and S. enteritidis. A dose of 2 x 10(4) sporulated oocysts of E. tenella was given to each chicken. In Experiment 1, each chicken was infected with 10(5) cfu/d of S. enteritidis for 3 consecutive d starting 1 d after coccidia exposure and necropsied 4, 7, 10, and 14 d after coccidial infection. In Experiments 2 and 3, each bird was infected with 10(2) cfu/d and 10(1) cfu/d of S. enteritidis respectively, for 2 d beginning 4 d after coccidia exposure, and were killed 7, 10, and 14 d postinfection with E. tenella. Results showed that interaction between S. enteritidis and E. tenella was significant in Experiments 1 and 2, but not in Experiment 3, manifesting that the cecal Salmonella population were significantly increased by coccidial infection in birds killed 4, 10, or 14 d after coccidia exposure in Experiment 1 and in birds killed 14 d after coccidial infection in Experiment 2. The dose size of S. enteritidis was an important factor for the synergistic relationship between S. enteritidis and E. tenella. Frequency of recovery of S. enteritidis in liver and spleen was not increased by E. tenella infection.