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Endoscopy ; 47(5): 457-61, 2015 May.
Article in English | MEDLINE | ID: mdl-25479561

ABSTRACT

BACKGROUND AND STUDY AIM: We previously reported on a plastic stent that was coated with ethylenediaminetetraacetic acid (EDTA) and sodium cholate, which dissolved common bile duct (CBD) stones ex vivo. The aim of this study was to investigate the safety and efficacy of such stents on biliary stones in a live porcine model. METHODS: Stents without coating or with degradable membranes containing 0 % or 50 % EDTA and sodium cholate were inserted together with human CBD stones into the porcine CBD. Serum laboratory variables, histological examinations of the bile duct, and the weight change in stones were compared during and after stent placement for 6 months. RESULTS: A total of 16 pigs were included (5 no coating, 5 0 % coating, 6 50 % coating). Biliary stones showed decreased weight in all groups; however, stones in the group with 50 % coated stents showed a greater reduction in weight compared with the no coating and the 0 % coating groups (269 ±â€Š66 mg vs. 179 ±â€Š51 mg [P = 0.09]; 269 ±â€Š66 mg vs. 156 ±â€Š26 mg [P = 0.01], respectively). CONCLUSIONS: The plastic stent coated with 50 % agent enhanced CBD stone dissolution in vivo and may be a promising tool for patients with difficult biliary stones.


Subject(s)
Calcium Chelating Agents/administration & dosage , Drug-Eluting Stents , Edetic Acid/administration & dosage , Gallstones/therapy , Sodium Cholate/administration & dosage , Alanine Transaminase/blood , Amylases/blood , Animals , Aspartate Aminotransferases/blood , Cholangiography , Disease Models, Animal , Drug-Eluting Stents/adverse effects , Gallstones/blood , Gallstones/diagnostic imaging , Leukocyte Count , Plastics , Swine
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