Independent and incremental value of severely enlarged left atrium in risk stratification of very elderly patients with chronic systolic heart failure.

The authors sought to assess the impact on survival of demographic, clinical, and echo-Doppler parameters in patients with chronic heart failure due to left ventricular systolic dysfunction divided according to age groups. This study included 734 patients (age 69±11 years) who were classified into tertiles of age: I (22-66 years), II (67-76 years), and III (77-94 years). Severely enlarged left atrial size was defined as ≥52 mm in men and ≥47 mm in women. Multivariable analysis identified male sex (P=.018) and severely enlarged left atrium (P=.024) as significant correlates of all-cause mortality in the very elderly cohort, while restrictive filling pattern (RFP) (P=.004) and New York Heart Association class III or IV (P=.005) among patients of the first tertile and RFP (P=.028) among patients in the second tertile were independently associated with mortality after 30±21 months of follow-up. At the interactive stepwise model in the very elderly population, a severely enlarged left atrium, added to the model after clinical parameters and ejection fraction, moved the chi-square value from 20.7 to 25.8 (P=.048). RFP emerged as the single best predictor of all-cause mortality in the younger and intermediate ranges, whereas severely enlarged left atrium was the best predictor in the very elderly.

Relationship between insulin resistance and left ventricular diastolic dysfunction in patients with impaired glucose tolerance and type 2 diabetes.

AIM: The aim of this study was to explore the relationship between insulin resistance (IR) and the left ventricular diastolic function in patients with type 2 diabetes and subjects with impaired glucose tolerance (IGT). METHODS: The study included 119 subjects who underwent oral glucose tolerance test (OGTT). IR was assessed using Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) and Quantitative Insulin Sensitivity Check Index (QUICKI). Left ventricular diastolic function was assessed using trans-thoracic Doppler echocardiography. RESULTS: Based on the OGTT results, 29 subjects had normal glucose tolerance (NGT), 20 subjects had impaired glucose tolerance (IGT), and 70 patients had type 2 diabetes. There were significant differences among the patients in groups with NGT, IGT and diabetes regarding HOMA-IR (4.20 +/- 1.20 vs. 6.45 +/- 3.83 vs. 8.70 +/- 6.26; P < 0.001) and QUICKI (0.54 +/- 0.11 vs. 0.49 +/- 0.08 vs. 0.47 +/- 0.08; P < 0.001). In subjects with NGT, IGT and patients with diabetes, the pulsed Doppler transmitral variables were: E-wave (0.72 +/- 0.16 cm/s vs. 0.62 +/- 0.13 cm/s vs. 0.58 +/- 0.17 cm/s; P < 0.001), A-wave (0.61 +/- 0.13 cm/s vs. 0.62 +/- 0.11 cm/s vs. 0.71+/- 0.14 cm/s; P = 0.006) and E/A ratio (1.22 +/- 0.33 vs. 1.02 +/- 0.24 vs. 0.85 +/- 0.26; p < 0.001). The proportion of subjects with an E/A ratio <1 was 27.6% in the group with NGT, 55% in the group with IGT and 75.7% in the group with diabetes (P < 0.001). The E/A ratio correlated with HOMA-IR (r = -0.30, p = 0.001) and QUICKI (r = 0.37, p < 0.0001). Multiple linear regression model showed that IR (assessed by QUICKI) was an independent correlate of diastolic dysfunction (P = 0.034). CONCLUSIONS: In subjects with impaired glucose tolerance and patients with type 2 diabetes, insulin resistance is associated with impaired diastolic function of the left ventricle.

Non-insulin dependent diabetes as an independent predictor of asymptomatic left ventricular diastolic dysfunction.

AIM: To assess the prevalence of diastolic dysfunction of the left ventricle in patients with non-insulin-dependent diabetes mellitus (NIDDM) and its relation to patients' age and duration of diabetes. METHODS: This case-control study included 228 subjects. The group of cases consisted of 114 patients with NIDDM. The group of controls included 114 subjects without diabetes, enrolled in the study at the same time as the group of cases. Diastolic function of the left ventricle was assessed by pulsed Doppler echocardiography. The ratio between the maximal early filling velocity (E wave) and the maximal late (atrial) filling velocity (A wave) less than 1 (E/A ratio<1) was considered as a criterion for left ventricle diastolic dysfunction. RESULTS: The E/A ratio<1 was found in 75 patients (65.8%) in the group with diabetes, and in 38 subjects (33.3%) in the control group (P=0.001). Multiple logistic regression model showed that diabetes was the strongest independent correlate of left ventricle diastolic dysfunction (odds ratio 8.92, 95% confidence interval [CI] 4.20 to 18.52, P<0.001). In the group with diabetes, the multivariate analysis showed that age (P=0.001), level of triglycerides (P=0.006), history of smoking (P=0.011), and the duration of diabetes (P=0.019) were independently associated with left ventricle diastolic dysfunction. CONCLUSIONS: Non-insulin dependent diabetes is an independent predictor of left ventricular diastolic dysfunction in patients without clinical evidence of structural heart disease. In patients with NIDDM, the age, history of smoking, plasma level of triglycerides, and the duration of diabetes were independently associated with the diastolic dysfunction of the left ventricle.

Reduced left ventricular diastolic function in asymptomatic patients with non-insulin-dependent diabetes mellitus.

AIMS: This prospective study was performed to assess the provalence of diastolic dysfunction of the lelt ventricle (LV) in patients with noninsulin-dependent diabetes mellitus (NIDDM), and the effect of patients' age and the duration of diabetes in the appearance of this dysfunction. METHODS AND RESULTS: We studied 103 patients with NIDDM (group I) and 103 subjects without diabetes (group 2). SF and EF were lower in patients with NIDDM as compared with the control group (32.7+/-5.5%, vs. 34.2+/-5.2%, p=0.04 and 61+/-8.7% vs. 64.4+/-8.1, p<0.01, respectively). The EA ratio <1 is found in 71 (68.9%) patients with NIDDM, and in 36 (34.9%) subjects of the control group (p<0.01). The age of patients had significant correlation with E/A ratio of transmitral Doppler flow (r = -0.38, p<0.01). The duration of diabetes had significant correlation with EF (r = -0.26, p<0.01) and with E/A ratio (r= -0.295, p<0.01). Body mass index and waist/hip ratio did not have significant correlation with EF and with E/A ratio. CONCLUSIONS: In asymptomatic NDDM patients there was a more frequent reduction of systolic and diastolic function of the LV, as compared with healthy subjects. The presence of diastolic dysfunction of the LV in NDDM patients is dependent on the age of the patients and duration of diabetes.

Transmitral pulsed-Doppler echocardiography is a more accurate technique compared with two-dimensional echocardiography using dobutamine, in patients with one vessel coronary artery disease.

UNLABELLED: To examine the effects of dobutamine on pulsed-Doppler left ventricular filling indices and its utility for evaluation of CAD we studied 14 patients with normal coronary arteries (Group 1) and 39 patients with significant CAD (>70% diameter stenosis). Patients with coronary artery disease (CAD) were divided into two groups: patients with one-vessel coronary disease (Group 2); and those with multivessel CAD (Group 3). After stopping cardioactive treatment, patients underwent incremental dobutamine stress (5, 10, 20, 30 and 40 microg/kg/min) during pulsed-Doppler interrogation of diastolic filling with simultaneous heart rate and blood pressure measurements. The following transmitral Doppler variables were measured at baseline and at peak-dose of dobutamine: peak early (E) and peak atrial (A) velocity; E/A ratio; acceleration time (AT) and deceleration time (DT) of E wave; isovolumic relaxation time (IVRT); and time-velocity integral (TVI). Two-dimensional echocardiography was performed to detect regional asinergy and analyzed using a 16 segment model. RESULTS: Normals and CAD patients showed comparable changes in heart rate and blood pressure (P=NS between groups). Intergroup analysis of the changes of transmitral flow showed the significant changes for these indices (P<0.001): E velocity (-2.78+/-10.04, 12.4+/-9.4 and 16.47+/-10.65 cm/s); AT of E wave (1.66+/-2.47, -5.2+/-1.38 and -4.66+/-2.39 m/s(2)); DT of E wave (-0.23+/-0.18, 0.2+/-0.2 and 0.2+/-0.28 m/s(2)); and TVI of transmitral flow (-1.26+/-0.7, 3.5+/-1.75 and 4.1+/-1.66 cm), respectively for Groups 1, 2 and 3. All other transmitral Doppler variables showed insignificant changes (P=NS) to dobutamine between groups. It is important that the significance of these changes were the same for patients with one-vessel and those with multivessel coronary disease. In conclusion, during dobutamine stress testing, patients with CAD, had an abnormal response of these transmitral Doppler indices: E wave; AT of E wave; DT of E wave; and the TVI of transmitral flow. The abnormal responses of these Doppler indices of left ventricular filling are more accurate markers of significant single vessel CAD than new wall motion abnormalities during conventional DSE.