Camrelizumab-induced anaphylactic reaction: a case report and literature review.

Camrelizumab is an immune checkpoint inhibitor clinically used to treat various types of tumours. In this study, the authors provided the first report of a case of an anaphylactic reaction induced by camrelizumab in the treatment of a patient with squamous cell carcinoma of the floor of the mouth. The patient, a 58-year-old man, was diagnosed with advanced squamous cell carcinoma of the floor of the mouth, with cancer infiltration and multiple metastases. He underwent treatment for nine cycles, in which cycles 1-5 he received camrelizumab, albumin-bound paclitaxel, and cisplatin (200 mg of camrelizumab each time, every 3 weeks), with no adverse reactions; in cycle 6, he received albumin-bound paclitaxel and cisplatin, with no adverse reactions; and in cycles 7-9, he received camrelizumab and albumin-bound paclitaxel. However, 30 min after 8th administration of camrelizumab (cycle 9), he suddenly developed sweating, a pale complexion, clamminess and cyanosis of the limbs (percutaneous arterial oxygen saturation [SpO2] = 82%, blood pressure [BP] = 79/49 mmHg, heart rate [HR] = 83 beats/min [bpm] and respiratory rate [RR) = 12 bpm). The patient underwent intravenous infusion of methylprednisolone (80 mg) combined with dopamine to boost the BP; he regained consciousness 20 min later, and many parts of his skin appeared smooth, with no desquamation and accompanied by itching erythema, especially on the upper limbs. Approximately 2 h after treatment, the patient's skin erythema subsided (vital sign monitoring results: SpO2 = 100%, BP = 122/84 mmHg, HR = 91 bpm and RR = 17 bpm); the patient did not complain about his obvious discomfort. Despite the rarity of acute anaphylactic reactions among immune-related adverse reactions, great importance should be given to anaphylactic reactions of camrelizumab due to its extensive clinical application.

Multi-spectral compatible metasurface with low infrared emissivity, independent microwave complex-amplitude control, and high visible transparency.

With the rapid development of communication technology and detection technology, it is difficult for devices operating in a single spectrum to meet the application requirements of device integration and miniaturization, resulting in the exploration of multi-spectrum compatible devices. However, the functional design of different spectra is often contradictory and difficult to be compatible. In this work, a transparent slit circular metasurface with a high filling ratio is proposed to achieve the compatibility of microwave, infrared and visible light. In the microwave, based on the Pancharatnam-Berry phase theory, the continuous amplitude and binary phase can be customized only by rotating the slit angle to achieve an Airy beam function at 8-12 GHz. In the infrared, the mean infrared emissivity is reduced to 0.3 at 3-14 µm by maintaining high conductive filling ratio, and in visible light, based on the transparency of materials, the mean transmittance can achieve 50% at 400-800 nm. All the results can verify the multi-spectral compatibility performance, which can also verify the validity of our design method. Importantly, the multi-spectral compatible metasurface contributes an option for multifunctional integration, which can be further applied in communication, camouflage, and other fields.

Vision-driven metasurfaces for perception enhancement.

Metasurfaces have exhibited unprecedented degree of freedom in manipulating electromagnetic (EM) waves and thus provide fantastic front-end interfaces for smart systems. Here we show a framework for perception enhancement based on vision-driven metasurface. Human's eye movements are matched with microwave radiations to extend the humans' perception spectrum. By this means, our eyes can "sense" visual information and invisible microwave information. Several experimental demonstrations are given for specific implementations, including a physiological-signal-monitoring system, an "X-ray-glasses" system, a "glimpse-and-forget" tracking system and a speech reception system for deaf people. Both the simulation and experiment results verify evident advantages in perception enhancement effects and improving information acquisition efficiency. This framework can be readily integrated into healthcare systems to monitor physiological signals and to offer assistance for people with disabilities. This work provides an alternative framework for perception enhancement and may find wide applications in healthcare, wearable devices, search-and-rescue and others.

Dispersion-boosting wideband electromagnetic transparency under extreme angles for TE-polarized waves.

Half-wave wall is the most common method of achieving electromagnetic (EM) transparency. Transmission windows can be formed when reflected waves are out of phase. Due to the interference mechanism, these windows are dependent on the frequency and incident angle of EM waves, leading to limited bandwidth, especially under extreme angles. In this letter, we propose to extend the bandwidth of the transmission window under extreme angles by utilizing dispersion. To this end, long metallic wires are embedded into the half-wave wall matrix, without increasing the physical thickness. Due to the plasma-like behavior of metallic wires under TE-polarization, the effective permittivity of the half-wave wall, rather than keeping constant, increases with frequency nonlinearly. Such a dispersion will boost wideband transparency in two aspects. On one hand, an additional transmission window will be generated where the effective permittivity equals that of the air; on the other hand, the 1st- and 2nd-order half-wave windows will be made quite closer. By tailoring the dispersion, the three windows can be merged to enable wideband transparency under extreme incident angles. A proof-of-principle prototype was designed, fabricated, and measured to verify this strategy. Both simulated and measured results show that the prototype can operate in the whole Ku-band under incident angle [70°, 85°] for TE-polarized waves. This work provides an effective method of achieving wideband EM transparency under extreme angles and may find applications in radar, communications, and others.

A method for high-precision measuring differential transformer asymmetry.

The differential transformer is an important component in the front-end electronics of high-precision capacitive position sensing circuits, which are widely employed in space inertial sensors and electrostatic accelerometers. The position sensing offset, one of the space inertial sensors' most critical error sources in the performance range, is dominated by the differential transformer asymmetry and requires a high-precision evaluation. This paper proposes a method to assess differential transformers' asymmetry and realize a prototype circuit to test a transformer sample. The results show that the asymmetry measurement precision can achieve 0.6 ppm for the transformer with an asymmetry level of about -278.2 ppm.

Dual-Channel Surface Waves Directional Radiation with Customizable Intensity and Switchable Pattern.

Achieving the conversion from surface waves (SWs) to propagating waves has captivated long-standing interest, and various ingenious metasurfaces benefiting from the powerful control capability for electromagnetic waves are able to realize efficient SWs directional radiation. Nevertheless, most existing schemes still suffer from the bottlenecks of single radiation channel, uncontrollable radiation intensity, and immutable radiation pattern, which immensely hinder their practical application in high-integration intelligent devices. Herein, a series of appealing strategies are proposed to achieve the dual-channel SWs directional radiation with customizable radiation intensity and switchable radiation pattern. The dual-channel SWs radiation metadevice based on the phase modulation metasurface is designed to directionally radiate SWs in left-handed circular polarized channel and right-handed circular polarized channel and possesses the broadband frequency scanning characteristic. More strikingly, the intensity-customizable dual-channel SWs radiation metadevice loaded with lumped resistors can control the realized gain of two circular polarized radiation beams, and the pattern-switchable dual-channel SWs radiation metadevice loaded with PIN diodes can dynamically adjust the radiation direction of the radiation beams. Numerous simulations and experiments of the proof-of-concept prototypes with modular design corroborate the theoretical predictions. Our methodology shows unprecedented flexibility in regulating SWs directional radiation and has enormous potential in engineering applications.

Broadband 2D phase-gradient metasurface for linearly-polarized waves by suppressing Lorentz resonance of meta-atoms.

Metasurfaces have exhibited versatile capacities of controlling electromagnetic (EM) waves due to the high degree of freedom of designing artificially engineered meta-atoms. For circular polarization (CP), broadband phase gradient metasurfaces (PGMs) can be realized based on P-B geometric phase by rotating meta-atoms; while for linear polarization (LP), realization of broadband phase gradients has to resort to P-B geometric phase during polarization conversion and polarization purity has to be sacrificed for broadband properties. It is still challenging to obtain broadband PGMs for LP waves without polarization conversion. In this paper, we propose the design of 2D PGMs by combining the inherently wideband geometric phases and non-resonant phases of meta-atom, under the philosophy of suppressing Lorentz resonances that usually bring about abrupt phase changes. To this end, an anisotropic meta-atom is devised which can suppress abrupt Lorentz resonances in 2D for both x- and y-polarized waves. For y-polarized waves, the central straight wire is in perpendicular to electric vector Ein of incident waves, Lorentz resonance cannot be excited although the electrical length approaches or even exceeds half a wavelength. For x-polarized waves, the central straight wire is in parallel with Ein, a split gap is opened on the center of the straight wire so as to avoid Lorentz resonance. In this way, the abrupt Lorentz resonances are suppressed in 2D and the wideband geometric phase and the gradual non-resonant phase are left for broadband PGM design. As a proof of concept, a 2D PGM prototype for LP waves was designed, fabricated and measured in microwave regime. Both simulated and measured results show that the PGM can achieve broadband beam deflection for reflected waves for both x- and y-polarized waves in broadband, without changing the LP state. This work provides a broadband route to 2D PGMs for LP waves and can be readily extended to higher frequencies such as terahertz and infrared regimes.

High temperature infrared-radar compatible stealthy metamaterial based on an ultrathin high-entropy alloy.

In this work, a high temperature infrared (IR) and radar compatible stealthy metamaterial based on ultrathin high-entropy alloy are proposed. From room temperature to 600°C, the fabricated radar absorption layer (RAL) can have wideband absorption in X-band (8.2-12.4 GHz) with average absorption 78% owing to magnetic resonance and ohmic loss. The ultrathin high-entropy alloy film is further design as infrared shielding layer (ISL) due to low-emissivity property. The ISL and RAL consist of the IR-microwave compatible stealth metamaterial. It can give rise to the strong reduction of both radar wave reflection and infrared thermal emission. Its bandwidth (absorption over 90%) is 2.15 GHz. In the infrared atmosphere window, it can suppress a half of thermal radiation. This is realized by the subtle combination between the RAL and specifically designed ISL that control the infrared emission and microwave absorption. These results show that they are practically very promising for the application of a radar-infrared bi-stealth technology in high temperature environment.

Polarization-multiplexed full-space metasurface simultaneously merging with an ultrawide-angle antireflection and a large-angle retroreflection.

Multifunctional electromagnetic (EM) metasurfaces are capable of manipulating electromagnetic waves with kaleidoscopic functions flexibly, which will significantly enhance integration and applications of electronic systems. However, most known design schemes only realize the reflection or transmission functions under a specific angle range, which wastes the other half EM space and restricts wider applications of multifunctional metadevices. Herein, an encouraging strategy of broadband and wide-angle EM wavefronts generator is proposed to produce two independent functions, i.e., antireflections for transverse electric (TE) waves and retroreflection for transverse magnetic (TM) waves, which utilizes band-stop and bandpass responses of the metasurface, respectively. As a feasibility verification of this methodology, a three-layer cascaded metasurface, composed of anisotropic crossbar structures patterned on the two surfaces of a dielectric substrate with sandwiched orthogonal metal-gratings, is designed, fabricated, and measured. Both the simulated and experimental results are in good accordance with theoretical analyses. This full-space metasurface opens up a new route to multifunctional metasurfaces and will further promote engineering applications of metasurfaces.

Tailorable Switching of Transmission Modes between Waveguide and Spoof Surface Plasmon Polariton for Flexible and Dynamic Control of Phase Shift.

Programmable metamaterials are suitable for their dynamic and real-time control capabilities of electromagnetic (EM) functions in radars and antenna communications, but it remains a challenge to achieve dynamic modulation of arbitrary transmission phase with high transmission efficiency. Here, we propose a paradigm to tailor transmission phase shift in real time by switching modes between waveguide and SSPP based on the voltage-driven PIN diodes. Step-like phase shift is achieved by the "ON" and "OFF" states of PIN diodes, while continuous phase regulation is by the characteristic of the nonlinear region between those two states. As validations, three systems with programmable functionalities are implemented, including the multibeam generator, the dual-beam scanner, and the active phased-array antenna. The experimental results are consistent with simulation, which verify the feasibility of the proposed approach. Our work offers an alternative route for transmission full-phase modulation and provides unprecedented potential for high-gain, real-time, and multidimensional EM capabilities in applications such as active phased array radars, self-adaption radomes, smart beam shaping.

Smart Metasurface for Active and Passive Cooperative Manipulation of Electromagnetic Waves.

Integrating active and passive manipulation of electromagnetic (EM) waves has significant advantages for the caliber synthesis of microwave and optical integrated devices. In previous schemes, most reported designs focus only on active ways of manipulating self-radiating EM waves, such as antennas and lasers, or passive ways of manipulating external incident EM waves, such as lenses and photonic crystals. Here, we proposed a paradigm that integrates active and passive manipulation of EM waves in a reconfigurable way. As demonstrated, circularly polarized, linearly polarized, and elliptically polarized waves with customized beams are achieved in passive operation by merging Pancharatnam-Berry phases and dynamic phases, while the radiating EM waves with a customized gain are achieved by coupling the coding elements with the radiation structure in the active manipulation. Either active or passive manipulation is determined by the sensed signals and operating state to reduce detectability. Encouragingly, the proposed strategy will excite new sensing and communication opportunities, enabling advanced conceptions for next-generation compact EM devices.

Mesoporous multi-valence manganese oxides composite nanotubes boosting long-life lithium-ion batteries.

Multi-component nano-oxide composite materials may present special synergistic effects as anode materials for lithium-ion batteries. Mesoporous ß-MnO2/Mn3O4 composite nanotubes are built here via controlling the deoxidation process of carbon-coating to induce a partial phase transition of high valence manganese dioxides. Compared to single ß-MnO2 nanotubes or Mn3O4@C nanotubes, the mesoporous ß-MnO2/Mn3O4@C composite nanotubes exhibit superior electrochemical properties. 679 mA h g-1 of reversible specific capacity and 86% of capacity retention after 1000 cycles at 1 A g-1 current density are obtained. The excellent performance is attributed to the unique multiple phase transitions regulation phenomena of manganese oxide occurring in the ß-MnO2/Mn3O4 composite material during the electrochemical processes, which significantly extends the cycle life of the ß-MnO2/Mn3O4 composite material.

Deep-Learning-Empowered Holographic Metasurface with Simultaneously Customized Phase and Amplitude.

Metasurfaces with simultaneously and independently controllable amplitude and phase have provided a higher degree of freedom in manipulating electromagnetic (EM) waves. Compared with phase- or amplitude-only modulation, the capability of simultaneously controlling the phase and amplitude of EM waves can enable holography with a higher resolution. However, this drastically increases the design complexity of holographic metasurfaces, and the design process is usually quite time-consuming. In this paper, we propose an inverse design of meta-atoms that can simultaneously and independently tailor the phase and amplitude of transmitted waves using customized deep ResNet while eliminating the coupling of parameters. To demonstrate the design method, two holographic metasurfaces were designed using the trained network without the need for parameter sweeping, which will significantly enhance design efficiency. Prototypes were fabricated and measured. Both the simulated and measured results show that high-resolution holography is obtained, which sufficiently verifies the reliability of the design method. Our work paves the way for the intelligent design of metasurfaces and can also be applied to the design of other artificial materials or surfaces.

Large-angle broadband transmission of electromagnetic waves through dielectric plates by embedding meta-atoms.

In many practical applications, dielectric electromagnetic (EM) windows are usually under large-angle incidence of EM waves rather than normal incidence. To guarantee normal operation of devices inside, high transmission must be maintained under large incident angles, especially for TE-polarized waves. In this work, we propose a method of achieving broadband transmission of TE-polarized waves under large incident angles by embedding meta-atoms within dielectric plates. To this end, long metallic wires and S-shaped structures are embedded in the original dielectric plate, the former of which will dilute the effective permittivity due to plasma oscillation and the latter will increase the effective permeability due to induced strong current loops under large incident angles. In this way, two consecutive transmission peaks can be generated, forming a broad transmission band under large incident angles. A proof-of-principle Ku-band prototype was designed, fabricated, and measured to verify this strategy. Both simulated and measured results show that the prototype can operate in the whole Ku-band under incident angle [60°, 85°] for TE-polarized waves, with significantly enhanced transmission. This work provides an effective method of enhancing large-angle transmission of EM waves and may find applications in radar, communications and others.

Tailoring transmission window in a dynamic way with a multi-degree-of-freedom.

With the rapid development of wireless technology, the revolution of tailoring transmission window in dynamic way for the next generation communication systems is urgently required. However, the degree-of-freedom for switching transmission spectra of an effective medium still needs further investigation. Here, we propose a paradigm of solving this difficult academic issue via the method of bias-voltage-driven. Leveraging PIN diodes and varactor diodes into the predesigned positions of plasmonic meta-structures, the macro-control of transmission windows switch and the detailed dispersion manipulation can be separately achieved by synergy modulation of feed networks. Both the numerical simulations and experimental verifications are conducted to support the effectiveness of the proposed method. Significantly, the proposed paradigm presents great potential for applications in intelligent radome, adaptive communication systems, and other EM scenarios with multi-degree-of-freedom.

Dual-polarization multi-angle retroreflective metasurface with bilateral transmission windows.

Metasurfaces have provided unprecedented degrees of freedom in manipulating electromagnetic (EM) waves and also granted high possibility of integrating multiple functions into one single meta-device. In this paper, we propose to incorporate the retroreflection function with transmission function by means of metasurface design and then demonstrate a dual-polarization multi-angle retroreflective metasurface (DMRM) with bilateral transmission bands. To achieve high-efficiency retroreflections, the compact bend structures (CBSs), which exhibit high reflections around 10.0 GHz in X band, are added onto the substrate of the DMRM. Two selected metasurface elements are periodically arranged so as to form 0-π-0 phase profile. By delicately adjusting the periodicity, high-efficiency retroreflections can be produced for both TE and TM-polarized waves under both vertical incidence and oblique incident angles ±50.0°, with an average efficiency of 90.2% at the designed frequency. Meanwhile, the two metasurface elements exhibit high transmission properties and minor phase disparities in S, C and Ku bands, resulting in bilateral transmission windows. Prototypes were designed and fabricated. Both simulated and measured results verified our design. This work provides an effective means of integrating retroreflection functions with other functions and may find applications in target tracking, radomes and other sensor integrated devices in higher frequency or even optical frequency bands.

Extremely angle-stable transparent window for TE-polarized waves empowered by anisotropic metasurfaces.

Impedance mismatch generally exists upon interfaces between different media. This is especially true for TE-polarized waves with large incident angles since there is no Brewster effect. As a result, high-efficiency transmission can only be guaranteed within limited incident angle range. It is desirable that transparent windows possess robust angle-stability. In this work, we propose a strategy of realizing transparent windows with extreme angle-stability using anisotropic metasurfaces. Different from traditional isotropic materials, anisotropic metasurfaces require specific three-dimensional permittivity and permeability parameters. Theoretical formulas are derived to realize a highly efficient transmission response without angular dispersion. To validate our design concept, a two-layer cascaded electromagnetic anti-reflector is designed, and it exhibits a characteristic impedance matching for nearly all incidence angles under TE-polarization illumination. As a proof-of-concept, a prototype of extremely angle-stable transparent window is fabricated and measured. Compared with the pure dielectric plate, the reflection coefficients are on average reduced by 40% at 13.5 GHz for TE-polarized waves from 0° to 80°. Therefore, we think, anisotropic cascaded electromagnetic transparent windows are capable of tailoring the electromagnetic parameter tensors as desired, and provide more adjustable degrees of freedom for manipulating electromagnetic wavefronts, which might open up a promising way for electromagnetic antireflection and find applications in radomes, IR windows and others.

Polarization meta-converter for dynamic polarization states shifting with broadband characteristic.

Polarization, as an important property of light, has been widely discussed in modern detecting and radar systems. A polarization converter that can be used to achieve dynamic control is regarded as an excellent alternative for implementing the integrated functionalities of communication and stealth. In this work, we propose a paradigm of meta-converter for dynamic polarization states shifting from linear-to-linear (LTL) to linear-to-circular (LTC) polarization. The strategy is achieved by loading voltage-controlled PIN diodes on the double-arrows metallic meta-resonators. The operation modes can be switched by changing the bias voltage. When the PIN diodes are turned on, the polarization meta-converter (PMC) will reflect and convert a linearly polarized electromagnetic (EM) wave into a circularly polarized one in 5.6-15.5 GHz with an axial ratio (AR) below 3dB. When the PIN diodes are turned off, the PMC will reflect and convert a linearly polarized EM wave into the orthogonal counterpart in 7.6-15.5 GHz with a polarization conversion ratio (PCR) over 88%. Simulations and experimental results show a good agreement, which manifests the feasibility of our proposed meta-converter. Moreover, the proposed PMC has great potential for polarization-dependent communication and stealth systems.

Tailoring permittivity using metasurface: a facile way of enhancing extreme-angle transmissions for both TE- and TM-polarizations.

The transmission of electromagnetic (EM) waves through a dielectric plate will be decreased significantly when the incident angle becomes extremely large, regardless of transverse electric (TE)- or transverse magnetic (TM)- polarization. In this regard, we propose a facile way of tailoring the permittivity of the dielectric material using metasurface to enhance the transmissions of both TE- and TM-polarized waves under extremely large incidence angles. Due to parallel or antiparallel electric fields induced by the metasurface, the net electric susceptibility is altered, and hence the effective permittivity can be tailored to improve the impedance matching on the two air-dielectric interfaces, which enhances the wave transmissions significantly under extreme incident angles. As an example, we apply this method to a typical ceramic-matrix composite (CMC) plate. By incorporating orthogonal meta-gratings into the CMC plate, its effective permittivity is reduced for the TE-polarized waves but increased for the TM-polarized waves under the extreme incidence angle, which can reduce the impedance for the TE-polarization and increase the Brewster angle for the TM-polarization. Therefore, the impedance matchings for both TE- and TM-polarizations are improved simultaneously and dual-polarized transmission enhancements are achieved under the extreme angles. Here, the transmission responses have been numerically and investigated using the finite-difference-time-domain (FDTD) method. A proof-of-principle prototype is designed, fabricated, and measured to verify this method. Both numerical simulations and measurement results show that the prototype can operate under extremely large incidence angles θi∈[75°,85°] with significant transmission enhancement for both TE- and TM-polarizations compared to the pure dielectric plate. This work provides a facile way to enhance the transmissions under extreme angles and can be readily extended to terahertz and optical frequencies.

Single-Layer Achiral Metasurface with Independent Amplitude-Phase Control for Both Left-Handed and Right-Handed Circular Polarizations.

Amplitude-phase control for circular polarized (CP) waves is experiencing a research upsurge in electromagnetics owing to the kaleidoscopic electromagnetic responses and promising application prospects of circular polarizations, and chiral metasurfaces are more facile to achieve a series of intriguing chiral phenomena than natural materials. However, it is difficult for most existing chiral metasurfaces to independently tailor the amplitude and phase of left-handed circular polarized and right-handed circular polarized waves at the same frequency as they suffer the drawbacks of large thickness, multiple layers, and complex structure. Herein, an innovative strategy of single-layer achiral metasurfaces of thickness 0.13λ0 is proposed to independently and simultaneously manipulate the amplitude and phase of orthogonal CP waves. As a proof of concept, an amplitude and phase controlled dual-channel meta-hologram is designed to reconstruct diverse images with high fidelity under orthogonal CP illumination, and the simulated and experimental results collectively validate the availability of our methodology. Significantly, the meta-hologram is also applicable to full polarization states according to the decomposition of electromagnetic waves. The inspiring design of single-layer achiral metasurfaces provides a simple and effective approach to explore chiral effects, and they possess enormous application potential in multitudinous microwave devices.