ABSTRACT
Introduction: The efficacy of dapagliflozin remains controversial for patients with type 2 diabetes and non-alcoholic fatty liver disease. We conduct this meta-analysis to explore the influence of dapagliflozin versus placebo on the treatment efficacy of type 2 diabetes complicated with non-alcoholic fatty liver disease. Methods: We have searched PubMed, EMbase, Web of science, EBSCO, and Cochrane library databases through November 2021 for randomized controlled trials (RCTs) assessing the efficacy of dapagliflozin versus placebo for type 2 diabetes complicated with non-alcoholic fatty liver disease. This meta-analysis is performed using the random-effect model. Results: Four RCTs are included in the meta-analysis. Overall, compared with patients with type 2 diabetes and non-alcoholic fatty liver disease, dapagliflozin treatment is associated with significantly reduced alanine aminotransferase (ALT, standard mean difference [SMD]=-1.27; 95% confidence interval [CI]span style="font-family: 'Times New Roman'">=-1.60 to -0.95; P<0.00001), aspartate-aminotransferase (AST, SMD=-1.37; 95% CI=-2.08 to -0.65; P=0.0002), fasting glucose (SMD=-0.78; 95% CI=-1.28 to -0.27; P=0.003) and HbA1c (SMD=-0.77; 95% CI=-1.21 to -0.34; P=0.0005), but demonstrated no obvious influence on homeostatic Model Assessment of Insulin Resistance (HOMA-IR, SMD=-0.36; 95% CI=-0.86 to 0.14; P=0.16). Conclusions: Dapagliflozin benefits to improve hepatic function and glucose control in patients with type 2 diabetes and non-alcoholic fatty liver disease, as evidenced by the reduction in ALT, AST, fasting glucose and HbA1c.
Subject(s)
Benzhydryl Compounds , Diabetes Mellitus, Type 2 , Glucosides , Non-alcoholic Fatty Liver Disease , Humans , Diabetes Mellitus, Type 2/complications , Diabetes Mellitus, Type 2/drug therapy , Glucose , Glycated Hemoglobin , Non-alcoholic Fatty Liver Disease/drug therapy , Randomized Controlled Trials as Topic , Treatment OutcomeABSTRACT
In July 2019-July 2020, we conducted a field trial to examine the effects of nitrogen addition (60 kg N·hm-2·a-1), biochar application (10 t·hm-2), and their combination on soil N2O emission and the relationship between soil N2O emission and environmental factors in a typical Moso bamboo (Phyllostachys edulis) plantation in Hangzhou City of Zhejiang Province. Soil N2O flux of Moso bamboo plantation was measured by the static chamber-gas chromatography technique. The results showed that nitrogen addition treatment increased the annual cumulative N2O emission by 14.6%, while biochar application and the combination treatment reduced it by 20.8% and 10.6%, respectively. Soil N2O flux rate was significantly correlated with soil temperature, NO3--N concentration, urease and protease activities, and soil NH4+-N concentration across all treatments. In conclusion, under the background of nitrogen deposition, the application of biochar would have a significant reduction effect on soil N2O fluxes in Moso bamboo plantations.
