Bacterial cellulose-based hydrogel with regulated rehydration and enhanced antibacterial activity for wound healing.

Bacterial cellulose (BC) hydrogels are promising medical biomaterials that have been widely used for tissue repair, wound healing and cartilage engineering. However, the high water content of BC hydrogels increases the difficulty of storage and transportation. Moreover, they will lose their original hydrogel structure after dehydration, which severely limits their practical applications. Introducing the bio-based polyelectrolytes is expected to solve this problem. Here, we modified BC and combined it with quaternized chitosan (QCS) via a chemical reaction to obtain a dehydrated dialdehyde bacterial cellulose/quaternized chitosan (DBC/QCS) hydrogel with repeated swelling behavior and good antibacterial properties. The hydrogel can recover the initial state on the macro scale with a swelling ratio over 1000 % and possesses excellent antimicrobial properties against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) with a killing rate of 80.8 % and 81.3 %, respectively. In addition, the hydrogel has excellent biocompatibility, which is conducive to the stretching of L929 cells. After 14 d of in vivo wound modeling in rats, it was found that the hydrogel loaded with pirfenidone (PFD) could promote collagen deposition and accelerate wound healing with scar prevention. This rehydratable hydrogel can be stored and transported under dry conditions, which is promising for practical applications.

Constructing Heptazine-COF@TiO2 Heterojunction Photocatalysts for Efficient Photodegradation of Acetaminophen under Visible Light.

Constructing heterojunction photocatalysts are widely applied to boost the photocatalytic activity of materials. Here, a novel covalent organic framework (COF) material with heptazine units was developed and hybridized with TiO2 nano particles (NPs) to fabricate the Heptazine-COF@TiO2 photocatalysts for acetaminophen (AAP) photodegradation. The successfully assembled heptazine unit endows the Heptazine-COF with outstanding semiconductor property (optical bandgap is 2.53 eV). The synthesized Heptazine-COF@TiO2 hybrids is proved to have the heterojunction structure with high visible light activity and fast charge-carrier mobility, and exhibits better performance in photodegradation of AAP under visible light. The excellent photodegradation efficiency (rate constant: 0.758 min-1 ) and high reusability (rate constant: 0.452 min-1 in the 6th  cycles) of the optimized sample outperform the traditional inorganic photocatalysts and other heterojunction photocatalysts. In addition, these photocatalysts present universal degradation activity for other dyes and antibiotics.

Highly Sensitive Fiber Crossbar Sensors Enabled by Second-Order Synergistic Effect of Air Capacitance and Equipotential Body.

Fiber crossbars, an emerging electronic device, have become the most promising basic unit for advanced smart textiles. The demand for highly sensitive fiber crossbar sensors (FCSs) in wearable electronics is increased. However, the unique structure of FCSs presents challenges in replicating existing sensitivity enhancement strategies. Aiming at the sensitivity of fiber crossbar sensors, a second-order synergistic strategy is proposed that combines air capacitance and equipotential bodies, resulting in a remarkable sensitivity enhancement of over 20 times for FCSs. This strategy offers a promising avenue for the design and fabrication of FCSs that do not depend on intricate microstructures. Furthermore, the integrative structure of core-sheath fibers ensures a robust interface, leading to a low hysteresis of only 2.33% and exceptional stability. The outstanding capacitive response performance of FCSs allows them to effectively capture weak signals such as pulses and sounds. This capability opens up possibilities for the application of FCSs in personalized health management, as demonstrated by wireless monitoring systems based on pulse signals.

Highly Sensitive Capacitive Fiber Pressure Sensors Enabled by Electrode and Dielectric Layer Regulation.

Capacitive pressure sensors play an important role in the field of flexible electronics. Despite significant advances in two-dimensional (2D) soft pressure sensors, one-dimensional (1D) fiber electronics are still struggling. Due to differences in structure, the theoretical research of 2D sensors has difficulty guiding the design of 1D sensors. The multiple response factors of 1D sensors and the capacitive response mechanism have not been explored. Fiber sensors urgently need a tailor-made theoretical research and development path. In this regard, we established a fiber pressure-sensing platform using a coaxial wet spinning process. Aiming at the two problems of the soft electrode modulus and dielectric layer thickness, the conclusions are drawn from three aspects: model analysis, experimental verification, and formula derivation. It makes up some theoretical blanks of capacitive fiber pressure sensors. Through the self-regulation of these two factors without a complex structural design, the sensitivity can be significantly improved. This provides a great reference for the design and development of fiber pressure sensors. Besides, taking advantage of the scalability and easy integration of 1D electronics, multipoint sensors prepared by fibers have verified their application potential in health monitoring, human-machine interface, and motion behavior analysis.

Bacterial cellulose-based film with self-floating hierarchical porous structure for efficient solar-driven interfacial evaporation.

Interface solar water evaporation is a mean of rapidly evaporating water using solar energy. However, it is still a challenge to obtain solar evaporators with simple assembly, durability and high photothermal performance. Here, we demonstrated an effective post foaming strategy for treating nitrogen-doped reduced graphene oxide/bacterial cellulose film (F-NRGO@BC) prepared by a simple in situ culture method. The composite film contains hierarchical porous structure and bubbles on the film, achieving an integrated self-floating interface evaporator with excellent light absorption (96.5 %) and high toughness (200.18 kJ m-3). Porous structure and low enthalpy of F-NRGO@BC make a high evaporation rate of 1.68 kg m-2 h-1 and a low thermal conductivity of 0.644 W m-1 K-1 to ensure effective energy efficiency and heat insulation. This design of controlling surface morphology and internal structure provides a novel way for large-scale preparation and high-performance evaporator.

Highly Sensitive Fiber Pressure Sensors over a Wide Pressure Range Enabled by Resistive-Capacitive Hybrid Response.

Soft capacitive pressure sensors with high performance are becoming increasingly in demand in the emerging flexible wearable field. While capacitive fiber pressure sensors have achieved high sensitivity, their sensitivity range is limited to low-pressure levels. As fiber sensors typically require preloading and fixation, this narrow range of high sensitivity poses a challenge for practical applications. To overcome this limitation, the study proposes resistive-capacitive hybrid response fiber pressure sensors (HFPSs) with three-layer core-sheath structures. The trigger and sensitivity enhancement mechanisms of the hybrid response are determined through model analysis and experimental verification. By adjustment of the sensitivity enhancement range of the hybrid response, the sensitivity attenuation of HFPSs is alleviated significantly. The obtained results demonstrate that HFPSs have excellent characteristics such as fast response, low hysteresis, wide response frequency, small signal drift, and good durability. The hybrid response enhances the practical sensitivity of HFPSs for various applications. With enhanced sensitivity, HFPSs can effectively monitor pulse signals at preloads ranging from 0 to 22.7 kPa. This wide range of preloads improves the fault tolerance of pulse monitoring and expands the potential application scenarios of fiber pressure sensors.

µPESI-MS/MS System for Screening and Quantitating Drugs in Plasma Samples.

Recently, we developed a novel microprobe electrospray ionization (µPESI) source and its coupled MS (µPESI-MS/MS) system. Here, we aimed to widely validate the µPESI-MS/MS method for quantitative analysis of drugs in plasma samples. Furthermore, the relationship between the quantitative performance of the µPESI-MS/MS method and the physicochemical properties of target drugs was analyzed. The µPESI-MS/MS methods for quantitative analysis of 5 representative drugs with a relatively wide range of molecular weight, pKa, and log P values were developed and validated. The results showed that the linearity, accuracy, and precision of these methods met the requirements of the European Medicines Agency (EMA) guidance. Then a total of 75 drugs from plasma samples were primarily detected using the µPESI-MS/MS methods, among which 48 drugs could be quantitatively measured. Logistics regression suggested that drugs with significantly greater log P and physiological charge had better quantitative performance using the µPESI-MS/MS method. Collectively, these results clearly demonstrate the practical application of the µPESI-MS/MS system as a rapid approach to the quantitative analysis of drugs in plasma samples.

Bacterial cellulose-based hydrogel with antibacterial activity and vascularization for wound healing.

Skin wounds need an appropriate wound dressing to help prevent bacterial infection and accelerate wound closure. Bacterial cellulose (BC) with a three-dimensional (3D) network structure is an important commercial dressing. However, how to effectively load antibacterial agents and balance the antibacterial activity is a lingering issue. Herein, this study aims to develop a functional BC hydrogel containing silver-loaded zeolitic imidazolate framework-8 (ZIF-8) antibacterial agent. The tensile strength of the prepared biopolymer dressing is >1 MPa, the swelling property is over 3000 %, the temperature can reach 50 °C in 5 min with near-infrared (NIR) and the release of Ag+ and Zn2+ is stable. In vitro investigation shows that the hydrogel displays enhanced antibacterial activity, and the bacteria survival ratios are only 0.85 % and 0.39 % against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus). In vitro cell experiments present that BC/polydopamine/ZIF-8/Ag (BC/PDA/ZIF-8/Ag) shows satisfactory biocompatibility and promising angiogenic ability. In vivo study, the full-thickness skin defect on rats demonstrates remarkably wound healing ability and accelerated skin re-epithelialization. This work presents a competitive functional dressing with effective antibacterial properties and accelerative angiogenesis activities for wound repair.

Anti-Fouling, Adhesive Polyzwitterionic Hydrogel Electrodes Toughened Using a Tannic Acid Nanoflower.

Conductive polyzwitterionic hydrogels with good adhesion properties show potential prospect in implantable electrodes and electronic devices. Adhesive property of polyzwitterionic hydrogels in humid environments can be improved by the introduction of catechol groups. However, common catechol modifiers can usually quench free radicals, resulting in a contradiction between long-term tissue adhesion and hydrogel toughness. By adding tannic acid (TA) to the dispersion of clay nanosheets and nanofibers, we designed TA-coated nanoflowers and nanofibers as the reinforcing phase to prepare polyzwitterionic hydrogels with adhesion properties. The hydrogel combines the mussel-like and zwitterionic co-adhesive mechanism to maintain long-term adhesion in underwater environments. In particular, the noncovalent cross-linking provided by the nanoflower structure effectively compensates for the defects caused by free-radical quenching so that the hydrogel obtained a high stretchability of over 2900% and a toughness of 1.16 J/m3. The hydrogel also has excellent anti-biofouling property and shows resistance to bacteria and cells. In addition, the hydrogel possesses a low modulus (<10 kPa) and ionic conductivity (0.25 S/m), making it an ideal material for the preparation of implantable electrodes.

The economic impact of porcine reproductive and respiratory syndrome outbreak in four Chinese farms: Based on cost and revenue analysis.

The economic impact after the outbreak of porcine reproductive and respiratory syndrome (PRRS) has been proven to be tremendous for pig production worldwide. However, the economic impact of the disease is not well understood in China. In our previous study, we acquired and analyzed the main production data (the number of weaned piglets, health costs, delayed marketing age, etc.) from the management system before and after the PRRS outbreaks occurring in November 2014, March 2015, December 2016, and February 2017. This study aimed to analyze and quantify the economic losses of the four PRRS outbreaks in Chinese herds. A straightforward approach was used to calculate additional costs and decreased revenues based on the PRRS-induced production deficiencies by average cost-of-production indices calculated from annual estimates of costs between 2014 and 2017. The results showed that economic losses varied between ¥668.14 and ¥1004.43 per sow in breeding herds from the outbreaks to regain the basic performance, with an average of ¥822.75 per sow, and the mean costs in the fattening herds (including nursery pigs) were ¥601.62 per sow, ranging from ¥318.64 to ¥937.14. Overall, the economic impact of PRRS on the whole herd was ¥1424.37 per sow. The majority of the losses were due to the reduction in the number of weaned piglets for breeding herds, and the increased feed cost (occupying 44.88%) was the primary source of loss for fattening herds. Our study fills the gap in knowledge of PRRS economics in China, enriches the data for veterinary economics, and re-stresses the necessity for producers and veterinarians to control PRRS effectively.

Pregnane X receptor promotes liver enlargement in mice through the spatial induction of hepatocyte hypertrophy and proliferation.

Nuclear receptor pregnane X receptor (PXR) can induce significant liver enlargement through hepatocyte hypertrophy and proliferation. A previous report showed that during the process of PXR-induced liver enlargement, hepatocyte hypertrophy occurs around the central vein (CV) area while hepatocyte proliferation occurs around the portal vein (PV) area. However, the features of this spatial change remain unclear. Therefore, this study aims to explore the features of the spatial changes in hepatocytes in PXR-induced liver enlargement. PXR-induced spatial changes in hepatocyte hypertrophy and proliferation were confirmed in C57BL/6 mice. The liver was perfused with digitonin to destroy the hepatocytes around the CV or PV areas, and then the regional expression of proteins related to hepatocyte hypertrophy and proliferation was further measured. The results showed that the expression of PXR downstream proteins, such as cytochrome P450 (CYP) 3A11, CYP2B10, P-glycoprotein (P-gp) and organ anion transporting polypeptide 4 (OATP4) was upregulated around the CV area, while the expression of proliferation-related proteins such as cyclin B1 (CCNB1), cyclin D1 (CCND1) and serine/threonine NIMA-related kinase 2 (NEK2) was upregulated around the PV area. At the same time, the expression of cyclin-dependent kinase inhibitors such as retinoblastoma-like protein 2 (RBL2), cyclin-dependent kinase inhibitor 1B (CDKN1B) and CDKN1A was downregulated around the PV area. This study demonstrated that the spatial change in PXR-induced hepatocyte hypertrophy and proliferation is associated with the regional expression of PXR downstream targets and proliferation-related proteins and the regional distribution of triglycerides (TGs). These findings provide new insight into the understanding of PXR-induced hepatomegaly.

Production Performance of Four Pig Herds Infected With Porcine Reproductive and Respiratory Syndrome Using the "Load-Close-Exposure" Approach in China.

Porcine reproductive and respiratory syndrome (PRRS) is one of the most important swine diseases causing enormous losses to pig producers all over the world. The intervention measure of "load-close-exposure" [interrupting the introduction of replacement pigs combined with whole-herd exposure to live PRRS virus (PRRSV)] has been widely used in North America and has shown wonderful outcomes in controlling PRRS in the field. In the present study, we performed analyses of the production performance of four herds acutely infected with PRRSV by adopting this measure for the first time in China. Our results showed that the development rate of gilts decreased by a mean of 8.56%, the farrowing rate of breeding sows decreased from 86.18 to 77.61%, the number of piglets born alive per sow decreased by a mean of 0.73 pigs, and the pre-weaning and post-weaning mortality of piglets increased by a mean of 2.74-4.97% compared to the parameters of 6 months before an outbreak. The time to PRRSV stability (TTS), defined as the time in weeks it took to produce PRRSV-negative pigs at weaning, is an important indicator of successful control of PRRSV. The median TTS among herds A, C, and D was 21.8 weeks (21.6 22.1 weeks). In herd B, TTS was 42.3 weeks, which could be explained by the double introduction of gilts. Our study suggests that the "load-close-exposure" strategy may be a good alternative for Chinese producers and veterinaries to control PRRS in the field.

Crack-Based Core-Sheath Fiber Strain Sensors with an Ultralow Detection Limit and an Ultrawide Working Range.

With the booming development of flexible wearable sensing devices, flexible stretchable strain sensors with crack structure and high sensitivity have been widely concerned. However, the narrow sensing range has been hindering the development of crack-based strain sensors. In addition, the existence of the crack structure may reduce the interface compatibility between the elastic matrix and the sensing material. Herein, to overcome these problems, integrated core-sheath fibers were prepared by coaxial wet spinning with partially added carbon nanotube sensing materials in thermoplastic polyurethane elastic materials. Due to the superior interface compatibility and the change in the conductive path during stretching, the fiber strain sensor exhibits excellent durability (5000 tensile cycles), high sensitivity (>104), large stretchability (500%), a low detection limit (0.01%), and a fast response time of ∼60 ms. Based on these outstanding strain sensing performances, the fiber sensor is demonstrated to detect subtle strain changes (e.g., pulse wave and swallowing) and large strain changes (e.g., finger joint and wrist movement) in real time. Moreover, the fabric sensor woven with the core-sheath fibers has an excellent performance in wrist bending angle detection, and the smart gloves based on the fabric sensors also show exceptional recognition ability as a wireless sign language translation device. This integrated strategy may provide prospective opportunities to develop highly sensitive strain sensors with durable deformation and a wide detection range.

Long-Term Genome Monitoring Retraces the Evolution of Novel Emerging Porcine Reproductive and Respiratory Syndrome Viruses.

Porcine reproductive and respiratory syndrome virus (PRRSV) causes tremendous economic losses to the swine industry worldwide. In China, novel PRRSVs have frequently emerged in recent years, but the evolutionary relationship among these viruses has remained unclear. In the present study, a 4-year PRRSV genome-monitoring study was performed on samples from a pig farm. We observed that NADC30-like PRRSVs with higher mutation rates replaced HP-PRRSVs as the epidemic strains. We monitored the variation in the same PRRSV strain evolved in a pig herd over 2 years and observed that the low genomic similarity of NADC30-like PRRSVs results from rapid mutation. We also showed that recombination events between NADC30-like and QYYZ-like PRRSVs resulted in the complex recombination patterns of PRRSVs, which have formed gradually over time. Furthermore, recombination of the same strain can occur at different locations and increase the diversity of recombination events. Overall, these findings interpret the evolutionary patterns of novel and emerging PRRSVs, information that is crucial for PRRSV control.

Hierarchically Designed Three-Dimensional Composite Structure on a Cellulose-Based Solar Steam Generator.

The emerging water purification technology represented by solar water evaporation has developed rapidly in recent years and is widely used in seawater desalination. However, the high reflectivity of sunlight and low efficiency of photothermal conversion greatly hinder its application prospects. In this paper, the hierarchical structure of the film was designed and optimized by the addition of carbon materials in the process of bacterial cellulose culture. A cellulose-based composite film material with a microporous structure was obtained, which can improve the photothermal evaporation rate and photothermal conversion efficiency from the structural principle to improve the stability of floating on the water. Bacterial cellulose (BC) as a three-dimensional carrier was combined with one-dimensional and two-dimensional (1D/2D) compounds of carbon nanotubes (CNT) and reduced graphene oxide (RGO) to form composite films for solar evaporation. By the addition of CNT-RGO (21.8 wt %), the composite showed prominent photothermal evaporation rate and photothermal conversion efficiency properties. Through in situ culture of BC, not only a tight structure can be obtained but also the surface of BC contains a large number of hydroxyl groups, which have many active sites to load photothermal materials. BC nanofibers, CNT, and RGO cooperate to form a porous network structure, which provides continuous double channels for the rapid transmission of water molecules and light paths, so as to form an excellent photothermal layer. The photothermal conversion efficiency is 90.2%, and the photothermal evaporation rate is 1.85 kg m-2 h-1 to achieve efficient solar interface evaporation. This is a high level of photothermal properties in a cellulose-based solar steam generator. The superior photothermal performance of this hybrid film possesses scalability and desalination ability.

Transcription Factor Specificity Protein 1 Regulates Inflammation and Fibrin Deposition in Nasal Polyps Via the Regulation of microRNA-125b and the Wnt/ß-catenin Signaling Pathway.

Nasal polyps (NPs) are multifactorial soft growths inside the nasal passages and are associated with chronic inflammation that originate from the nasal and paranasal sinus mucosae. This study focused on the role of microRNA (miR)-125b and the molecules associated with NP development. Differentially expressed miRNAs between nasal tissues from patients with chronic rhinosinusitis (CRS) with NP (CRSwNP) and CRS without NP (CRSsNP) were screened using microarray analysis. A murine model of CRSwNP was established. The expression of miR-125b in murine tissues was examined using reverse transcription quantitative polymerase chain reaction. Candidate upstream regulators of miR-125b were predicted using bioinformatics tools, and the binding relationship between specificity protein 1 (Sp1) and miR-125b was validated using luciferase and chromatin immunoprecipitation assays. Altered expression of Sp1 and miR-125b was induced to evaluate their relevance to the progression of NPs. miR-125b expression was significantly upregulated in NP tissues from patients with CRSwNP. Sp1 was confirmed as an upstream regulator that promotes miR-125b transcription in NPs. Overexpression of Sp1 reduced levels of d-dimer (an indicator of fibrinogen degradation products) and tissue-type plasminogen activator (t-PA) but increased eosinophil cationic protein and peroxidase levels, as well as the levels of inflammatory factors interleukin-5 (IL-5) and IL-8 in murine NP tissues. However, these trends were reversed after miR-125b downregulation. Sp1 and miR-125b were found to activate the Wnt/ß-catenin signaling pathway in NPs. This study demonstrated that Sp1, an upstream transcription factor of miR-125b, accumulates on the miR-125b promoter to activate its transcription, which induces inflammation and fibrin deposition in NP by activating the Wnt/ß-catenin axis.

Closed Reduction and Percutaneous Pinning in the Treatment of Humeral Distal Metaphyseal-Diaphyseal Junction Fractures in Children: A Technique Note and Preliminary Results.

Objective: The metaphyseal-diaphyseal junction (MDJ) fracture is an uncommon but problematic type of fracture occurring at the distal humerus in children. Closed reduction and fixation are challenging and may not be possible with the conventional reduction maneuver utilized in supracondylar fractures. The purpose of this study was to evaluate a novel closed reduction and percutaneous pinning (CRPP) technique for the treatment of these fractures. Methods: We retrospectively evaluated 14 children (8 boys and 6 girls) who underwent closed reduction and percutaneous fixation for the treatment of MDJ fractures. Six children who underwent treatment with a novel CRPP technique were enrolled as Group A. Eight children underwent the conventional reduction maneuver utilized in supracondylar fracture and were enrolled as Group B. Clinical and radiographic outcomes in the two groups were then compared. Results: In Group A, all six MDJ fractures were treated successfully with the novel CRPP technique without the need for open procedures or re-operation. No complications such as pin-site infection or iatrogenic nerve injury were found in this group. In group B, five of the eight fractures were treated successfully with the conventional CRPP technique; three fractures needed open reduction, and one of them had further surgery because of the loss of fixation. Children with successful CRPP in each group were included to compare the efficacy of the novel CRPP technique. The average duration of the surgery in Group A was significantly shorter than that in Group B (p < 0.001). At last follow-up, both groups obtained satisfactory clinical and radiographic outcomes. Conclusion: MDJ fractures can be reduced successfully and fixed stably via a novel CRPP technique, and laborious and frustrating attempts at closed reduction and further open reduction can be avoided.

Effects of Preoperative Pyloric Stenosis on Outcomes and Nutritional Status in 73 Patients Following Curative Gastrectomy for Gastric Cancer: A Retrospective Study from a Single Center.

BACKGROUND The aim of this study was to explore the potential impact of pyloric stenosis (PS) on the nutritional status, the incidence of postoperative complications, and the long-term prognosis of distal gastric cancer (GC) patients after curative resection. MATERIAL AND METHODS We retrospectively analyzed the data of 343 GC patients who underwent curative gastrectomy for gastric cancer between January 2010 and December 2013. All patients were divided into 2 groups according to the status of PS. Their clinical and pathological features, nutritional indicators, and incidence of postoperative complications were compared and potential prognostic factors were analyzed using the propensity score matching analysis (PSM). RESULTS Seventy-four (21.6%) patients had PS. Patients with PS had worse survival outcomes than those without PS (χ²=21.369, P<0.001). Multivariate survival analysis demonstrated that PS, depth of invasion, and lymph node metastasis (all P<0.05) were the independent predictors of overall survival (OS). Patients with PS had significantly higher lymph node metastasis in No. 3, 4sb, 4d, 6, 8a, 9, and 14v lymph nodes. Patients with PS had significantly lower preoperative BMI, more weight loss, and lower prealbumin than those without PS. There were no significant differences between the 2 groups in postoperative complications, morbidity, or mortality. CONCLUSIONS Distal GC patients with PS have poor clinicopathological and nutritional status and poor prognosis. However, PS does not increase surgery-related morbidity and mortality.

Therapeutic analysis of Herbert screw fixation for capitellar fractures via the anterior approach in adolescent patients.

OBJECTIVE: The aim of this study is to analyze the efficacy of open reduction and Herbert screw fixation for coronal fractures of the capitellum via the anterior approach in adolescents. METHODS: We retrospectively analyzed the clinical and imaging data of 15 adolescents with capitellar fractures who were admitted to our hospital from May 2014 to May 2019. The fracture was reduced through the cubital crease incision via the anterior approach and was internally fixated with Herbert screws. A follow-up was conducted after the operation to examine fracture healing and elbow function. The postoperative functional recovery of patients was evaluated with the Mayo Elbow Performance index (MEPI) and the Broberg-Morrey rating system. RESULTS: Patients underwent surgery 3.7 days after injury on average. Intraoperative fracture reduction was satisfactory. No vascular injury or nerve injury occurred. Bony union occurred in an average of 6 weeks after the operation. All adolescents completed a 12- to 36-month follow-up. At the last follow-up, the Mayo Elbow Performance index was considered excellent in 12 patients and good in three patients. The Broberg-Morrey score was considered excellent in 12 patients, good in two patients, and fair in one patient. CONCLUSION: Open reduction with Herbert screw fixation via the anterior approach is a feasible surgical method for the treatment of coronal fractures of the capitellum in adolescents. LEVELS OF EVIDENCE: Therapeutic, retrospective study-Level IV.

A Bulk-Heterostructure Nanocomposite Electrolyte of Ce0.8Sm0.2O2-δ-SrTiO3 for Low-Temperature Solid Oxide Fuel Cells.

Since colossal ionic conductivity was detected in the planar heterostructures consisting of fluorite and perovskite, heterostructures have drawn great research interest as potential electrolytes for solid oxide fuel cells (SOFCs). However, so far, the practical uses of such promising material have failed to materialize in SOFCs due to the short circuit risk caused by SrTiO3. In this study, a series of fluorite/perovskite heterostructures made of Sm-doped CeO2 and SrTiO3 (SDC-STO) are developed in a new bulk-heterostructure form and evaluated as electrolytes. The prepared cells exhibit a peak power density of 892 mW cm-2 along with open circuit voltage of 1.1 V at 550 °C for the optimal composition of 4SDC-6STO. Further electrical studies reveal a high ionic conductivity of 0.05-0.14 S cm-1 at 450-550 °C, which shows remarkable enhancement compared to that of simplex SDC. Via AC impedance analysis, it has been shown that the small grain-boundary and electrode polarization resistances play the major roles in resulting in the superior performance. Furthermore, a Schottky junction effect is proposed by considering the work functions and electronic affinities to interpret the avoidance of short circuit in the SDC-STO cell. Our findings thus indicate a new insight to design electrolytes for low-temperature SOFCs.