Uncertainty cues amplify late positive potential responses to aversive emotional stimuli.

Uncertainty is unavoidable, and maladaptive responses to uncertainty may underlie the etiology and maintenance of psychopathology. A general tendency to associate uncertainty with aversive consequences, a type of covariation bias, can amplify aversive emotional experiences. To address questions about uncertainty during emotion regulation, we examined the Late Positive Potential (LPP) - an electrocortical marker of attention to and appraisal of motivationally relevant emotional stimuli - during a task designed to measure the effect of covariation bias and its emotional response consequences. Event-related potentials (ERPs) were recorded while participants (N = 52) were presented with a pre-stimulus cue that either conveyed information about the valence of an upcoming emotional image, or left them in ambiguity. We replicated findings that demonstrate expectancy biases in a priori and online expectancies of emotion-eliciting images, as well as in a posteriori estimates for concurrence of uncertainty cues and aversive images. Moreover, we demonstrate a novel finding that uncertainty cues amplify the LPP in response to subsequent aversive emotional stimuli. These findings advance research by conjoining existing emotion regulation research on the LPP with study of the effects of uncertainty on emotional appraisal and highlight the importance of accounting for stimulus uncertainty in emotion regulation research.

Caring for you, me, and us: The lived experience of compassion in counselors.

There is growing interest in compassion within the context of counseling, given its potential to support the well-being of both clients and counselors. For counselors, compassion may improve self-care and protect against various empathy-related stressors, such as empathic distress. Compassion is commonly taught and studied according to a division of self-compassion or other-oriented compassion (also, other-compassion). However, it has long been recognized that the lived experience of compassion is not so neatly divided. The Buddhist traditions that have informed compassion science emphasize the interconnectedness of self and others, such that the lived experience of compassion can occur in more combined and holistic forms that orient toward suffering in both oneself and others. This may be especially important for understanding compassion in counseling, where the clinical utility of empathy for suffering may result in moments of shared suffering. We therefore conducted a qualitative study to explore how counselors with compassion training experience and use both self- and other-compassion, including an exploration of relationships between compassion orientations. Findings revealed self- and other-compassion could be experienced as relatively distinct, with benefits for both counselors and clients. Yet we also found ample evidence for the experience of self- and other-compassion in more interrelated and combined forms, with additional unique benefits. To our knowledge, these findings are the first evidence of combined compassion experiences in counselors, highlighting the need for more research on how self- and other-oriented compassion interrelate, as well as how they can be experienced and employed together in therapy. (PsycInfo Database Record (c) 2022 APA, all rights reserved).

Brief mindfulness training enhances cognitive control in socioemotional contexts: Behavioral and neural evidence.

In social contexts, the dynamic nature of others' emotions places unique demands on attention and emotion regulation. Mindfulness, characterized by heightened and receptive moment-to-moment attending, may be well-suited to meet these demands. In particular, mindfulness may support more effective cognitive control in social situations via efficient deployment of top-down attention. To test this, a randomized controlled study examined effects of mindfulness training (MT) on behavioral and neural (event-related potentials [ERPs]) responses during an emotional go/no-go task that tested cognitive control in the context of emotional facial expressions that tend to elicit approach or avoidance behavior. Participants (N = 66) were randomly assigned to four brief (20 min) MT sessions or to structurally equivalent book learning control sessions. Relative to the control group, MT led to improved discrimination of facial expressions, as indexed by d-prime, as well as more efficient cognitive control, as indexed by response time and accuracy, and particularly for those evidencing poorer discrimination and cognitive control at baseline. MT also produced better conflict monitoring of behavioral goal-prepotent response tendencies, as indexed by larger No-Go N200 ERP amplitudes, and particularly so for those with smaller No-Go amplitude at baseline. Overall, findings are consistent with MT's potential to enhance deployment of early top-down attention to better meet the unique cognitive and emotional demands of socioemotional contexts, particularly for those with greater opportunity for change. Findings also suggest that early top-down attention deployment could be a cognitive mechanism correspondent to the present-oriented attention commonly used to explain regulatory benefits of mindfulness more broadly.

One-Year Follow-Up of a Randomized Controlled Trial Piloting a Mindfulness-Based Group Intervention for Adolescent Insulin Resistance.

INTRODUCTION: To explore if a brief mindfulness-based intervention (MBI) leads to sustained, improved clinical outcomes in adolescents at-risk for type 2 diabetes (T2D). METHODS: Participants were 12-17y girls with overweight/obesity, elevated depression symptoms, and T2D family history participating in a randomized, controlled pilot trial of a six-session MBI vs. cognitive-behavioral therapy (CBT) group. At baseline and 1-year, mindfulness, depression, insulin resistance (IR), and body composition were assessed with validated instruments. RESULTS: One-year retention was 71% (n = 12) in MBI; 81% (n = 13) in CBT. At 1-year, depression decreased (Cohen's d = 0.68) and IR decreased (d = 0.73) in adolescents randomized to MBI compared to those in CBT. There were no significant between-condition differences in mindfulness, adiposity, or BMI. DISCUSSION: One-year outcomes from this randomized, controlled pilot trial suggest that brief MBI may reduce depression and IR in at-risk adolescents. Replication and exploration of mechanisms within the context of a larger clinical trial are necessary. CLINICAL TRIAL REGISTRATION: www.ClinicalTrials.gov, identifier NCT02218138.

Mindfulness increases prosocial responses toward ostracized strangers through empathic concern.

Four studies tested the proposition that mindfulness and its training fostered prosociality toward ostracized strangers. In discovery Study 1, dispositional mindfulness predicted greater empathic concern for, and more helping behavior toward, an ostracized stranger. Using an experimental design, Study 2 revealed that very briefly instructed mindfulness, relative to active control instructions, also promoted prosocial responsiveness to an ostracized stranger. Study 3 ruled out alternative explanations for this effect of mindfulness, showing that it did not promote empathic anger or perpetrator punishment, nor that the control training reduced prosocial responsiveness toward an ostracized stranger rather than mindfulness increasing it. Study 4 further ruled out the alternative explanation of relaxation in the experimental effects of mindfulness. In all studies, empathic concern mediated the relation between mindfulness and one or both of the helping behavior outcomes. Meta-analyses of the four studies revealed stable, medium sized effects of mindfulness instruction on prosocial emotions and prosocial behavior. Together these findings inform about circumstances in which mindfulness may increase prosocial responsiveness, and deepen our understanding of the motivational bases of prosociality. (PsycINFO Database Record

Mindfulness-based Group Intervention for an Adolescent Girl at Risk for Type 2 Diabetes: A Case Report.

CONTEXT: Behavioral lifestyle interventions to lower body mass index (BMI; kg/m2) are the standard approach for preventing adolescent-onset type 2 diabetes (T2D). Unfortunately, existing programs have had limited long-term success of lessening insulin resistance, the key physiological risk indicator for T2D. Underlying psychosocial factors, particularly depressive symptoms, have been related to insulin resistance, independent of BMI or body fat. Preliminary evidence indicates that mindfulness-based programs show promise for intervening with depression and T2D; yet, this approach is novel and data in adolescents are scarce. OBJECTIVE: The objectives of this study were (1) to evaluate the benefits, and potential underlying mechanisms, of a mindfulness-based intervention in adolescents at-risk for T2D with depressive symptoms and (2) to consider clinical implementation with this specific, psychologically, and medically at-risk adolescent population. DESIGN AND SETTING: The research team conducted a case study report. The setting was an outpatient therapy clinic and research laboratory at a university. PARTICIPANT: The participant was a 16-y-old female with elevated depressive symptoms, obesity, and insulin resistance, and a family history of T2D. INTERVENTION AND OUTCOMES: The intervention was a 6-wk mindfulness-based group program. The key outcomes were patterns of change in trait mindfulness, depression, and insulin resistance in the course of a 1-y follow-up. Secondary outcomes were patterns of change in reported-overeating patterns and cortisol awakening response. RESULTS: Compared with her scores at baseline, the participant displayed a pattern of increased trait mindfulness, decreased depressive symptoms, and lessening of insulin resistance immediately following the group program and at 1 y. BMI and body fat were stable. There was a remission in reported-overeating and a pattern of declining cortisol awakening response 1 y later. Participant feedback on the intervention was generally positive but also provided potential modifications to strengthen acceptability and effectiveness. CONCLUSIONS: The current case results suggest that teaching mindfulness skills to adolescent girls at risk for T2D with depressive symptoms may offer distinctive advantages for treating depression and T2D risk. Clinical implications for increasing the success of implementing mindfulness-based programs in this population include a focus on promotion of social connectedness within the group, implementation of strategies to increase adherence to home practice activities, and the use of facilitation techniques to promote concrete understanding of abstract mindfulness concepts. Future, adequately powered clinical trial data are required to test therapeutic mechanisms and recommended adaptations.

Pilot randomized controlled trial of a mindfulness-based group intervention in adolescent girls at risk for type 2 diabetes with depressive symptoms.

OBJECTIVE: (1) Evaluate feasibility and acceptability of a mindfulness-based group in adolescent girls at-risk for type 2 diabetes (T2D) with depressive symptoms, and (2) compare efficacy of a mindfulness-based versus cognitive-behavioral group for decreasing depressive symptoms and improving insulin resistance. DESIGN AND SETTING: Parallel-group, randomized controlled pilot trial conducted at a university. PARTICIPANTS: Thirty-three girls 12-17y with overweight/obesity, family history of diabetes, and elevated depressive symptoms were randomized to a six-week mindfulness-based (n=17) or cognitive-behavioral program (n=16). INTERVENTIONS: Both interventions included six, one-hour weekly group sessions. The mindfulness-based program included guided mindfulness awareness practices. The cognitive-behavioral program involved cognitive restructuring and behavioral activation. MAIN OUTCOME MEASURES: Adolescents were evaluated at baseline, post-intervention, and six-months. Feasibility/acceptability were measured by attendance and program ratings. Depressive symptoms were assessed by validated survey. Insulin resistance was determined from fasting insulin and glucose, and dual energy x-ray absorptiometry was used to assess body composition. RESULTS: Most adolescents attended ≥80% sessions (mindfulness: 92% versus cognitive-behavioral: 87%, p=1.00). Acceptability ratings were strong. At post-treatment and six-months, adolescents in the mindfulness condition had greater decreases in depressive symptoms than adolescents in the cognitive-behavioral condition (ps<.05). Compared to the cognitive-behavioral condition, adolescents in the mindfulness-based intervention also had greater decreases in insulin resistance and fasting insulin at post-treatment, adjusting for fat mass and other covariates (ps<.05). CONCLUSIONS: A mindfulness-based intervention shows feasibility and acceptability in girls at-risk for T2D with depressive symptoms. Compared to a cognitive-behavioral program, after the intervention, adolescents who received mindfulness showed greater reductions in depressive symptoms and better insulin resistance. ClinicalTrials.gov identifier: NCT02218138 clinicaltrials.gov.

Nonsynonymous HTR2C polymorphism predicts cortisol response to psychosocial stress II: Evidence from two samples.

The 5-HT2C receptor is the primary serotonin receptor located in the corticotrophin releasing hormone (CRH) neurons of the hypothalamus. These neurons initiate the signaling cascade that culminates in cortisol release. Therefore, genetic variation in the 5-HT2C receptor gene (HTR2C) is a prime candidate for affecting cortisol reactivity to stress. Accordingly, we examined the association of a nonsynonymous polymorphism (Cys23Ser; rs6318) in HTR2C with stress reactivity in two Trier Social Stress Tests conducted at separate sites. In both Study 1 (N=128) and Study 2 (N=185), Cys23 homozygous females and hemizygous males had greater cortisol reactivity. There was no relation between this polymorphism and self-reported affective response (Studies 1 and 2) or cardiovascular reactivity (Study 2). Additionally, the short/short genotype of a polymorphism (5-HTTLPR) in the serotonin transporter gene was associated with greater cortisol reactivity in Study 1 as well as in Study 2 (previously reported). The Cys23Ser polymorphism and the 5-HTTLPR were independently associated with cortisol reactivity in both studies. These findings emphasize the important role of genetic variation in the serotonin system on regulating cortisol reactivity to social evaluative stress. Comparison of the present associations with those of prior studies underscores the likely importance of situational and psychological factors in determining the direction and magnitude of the association between genotype and phenotype.

Meta-analytic evidence for effects of mindfulness training on dimensions of self-reported dispositional mindfulness.

Improvements in stable, or dispositional, mindfulness are often assumed to accrue from mindfulness training and to account for many of its beneficial effects. However, research examining these assumptions has produced mixed findings, and the relation between dispositional mindfulness and mindfulness training is actively debated. A comprehensive meta-analysis was conducted on randomized controlled trials (RCTs) of mindfulness training published from 2003-2014 to investigate whether (a) different self-reported mindfulness scale dimensions change as a result of mindfulness training, (b) key aspects of study design (e.g., control condition type, population type, and intervention type) moderate training-related changes in dispositional mindfulness scale dimensions, and (c) changes in mindfulness scale dimensions are associated with beneficial changes in mental health outcomes. Scales from widely used dispositional mindfulness measures were combined into 5 categories for analysis: Attention, Description, Nonjudgment, Nonreactivity, and Observation. A total of 88 studies (n = 5,787) were included. Changes in scale dimensions of mindfulness from pre to post mindfulness training produced mean difference effect sizes ranging from small to moderate (g = 0.28-0.49). Consistent with the theorized role of improvements in mindfulness in training outcomes, changes in dispositional mindfulness scale dimensions were moderately correlated with beneficial intervention outcomes (r = .27-0.30), except for the Observation dimension (r = .16). Overall, moderation analyses revealed inconsistent results, and limitations of moderator analyses suggest important directions for future research. We discuss how the findings can inform the next generation of mindfulness assessment. (PsycINFO Database Record

Trait Mindfulness Predicts Efficient Top-Down Attention to and Discrimination of Facial Expressions.

In social situations, skillful regulation of emotion and behavior depends on efficiently discerning others' emotions. Identifying factors that promote timely and accurate discernment of facial expressions can therefore advance understanding of social emotion regulation and behavior. The present research examined whether trait mindfulness predicts neural and behavioral markers of early top-down attention to, and efficient discrimination of, socioemotional stimuli. Attention-based event-related potentials (ERPs) and behavioral responses were recorded while participants (N = 62; White; 67% female; Mage = 19.09 years, SD = 2.14 years) completed an emotional go/no-go task involving happy, neutral, and fearful facial expressions. Mindfulness predicted larger (more negative) N100 and N200 ERP amplitudes to both go and no-go stimuli. Mindfulness also predicted faster response time that was not attributable to a speed-accuracy trade-off. Significant relations held after accounting for attentional control or social anxiety. This study adds neurophysiological support for foundational accounts that mindfulness entails moment-to-moment attention with lower tendencies toward habitual patterns of responding. Mindfulness may enhance the quality of social behavior in socioemotional contexts by promoting efficient top-down attention to and discrimination of others' emotions, alongside greater monitoring and inhibition of automatic response tendencies.

From mindful attention to social connection: The key role of emotion regulation.

Effective emotion regulation is important for high-quality social functioning. Recent laboratory-based evidence suggests that mindfulness may enhance emotion regulation in socioemotional contexts; however, little is known about mindful emotion regulation during in vivo social interactions. In a study of romantic couples, we assessed each partner's mindfulness and top-down attentional efficiency (with an Emotional Go/No-Go task) prior to sampling emotions and perceived connection with others during day-to-day social interactions. Analyses revealed that mindfulness-related differences in top-down attentional efficiency on the Emotional Go/No-Go predicted positive emotion during daily social interactions. In turn, positive emotion and two additional indices of social emotion regulation each mediated the relation between actor mindfulness and perceived social connection. In corresponding analyses, neither trait reappraisal nor suppression use predicted the outcomes, and all mindfulness relations held controlling for these strategies. Findings support a framework for investigating mindfulness and higher-quality social functioning, for which mindful emotion regulation may be key.