ABSTRACT
Continuous laser Doppler measurements of methyl nicotinate-induced skin inflammation have been used to evaluate the activities of three oral non-steroidal anti-inflammatory drugs, indomethacin 50 mg (Indocid), tiaprofenic acid 100 mg (Surgam) and sodium acetylsalicylate 1 g (Catalgine). They were compared in a single-blind, randomized, intra-individual comparison (N = 16) versus placebo (lactose). One hour after each drug was ingested, four concentrations of methyl nicotinate were applied to the subject's forearms. Simultaneous skin blood flow (SBF) measurements were then carried out on the four tested zones, by use of four calibrated laser Doppler flowmeters. Computerized processing of recorded SBF levels provided data related to flow amplitude, kinetics and magnitude (area under the curve) of the reactions. A detailed statistical analysis was performed to establish the selectivity of this type of test and the following points were demonstrated: adjustment of SBF data to baseline did not improve precision, data had to be log-transformed before analysis, and magnitude data gave the best product discrimination. Under the conditions of this study, i.e. one hour after oral administration and for the indicated doses, the tested products could be classified, in terms of anti-inflammatory activity, as follows: Lactose less than Indomethacin 50 mg = Tiaprofenic acid 100 mg less than Sodium acetylsalicylate 1 g.
Subject(s)
Anti-Inflammatory Agents, Non-Steroidal/pharmacology , Skin/drug effects , Adult , Anti-Inflammatory Agents, Non-Steroidal/administration & dosage , Aspirin/pharmacology , Dermatitis, Contact/drug therapy , Dermatitis, Contact/etiology , Female , Humans , Indomethacin/pharmacology , Male , Nicotinic Acids/administration & dosage , Propionates/pharmacology , Skin/blood supply , Vasodilation/drug effectsABSTRACT
The aim of this study was to compare the activities of the two main classes of topical anti-inflammatory drugs in methyl-nicotinate-induced skin inflammation, using a new methodology based on laser-Doppler velocimetry. Six topical non-steroidal anti-inflammatory drugs (NSAIDs) (bufexamac, diclofenac, ibuprofen, indomethacin, phenylbutazone and niflumic acid) and three topical corticosteroids (clobetasol propionate, hydrocortisone and hydrocortisone butyrate) were tested. Drugs were commercially available (except indomethacin) and were applied under occlusion for 4 h to the forearms of 16 healthy male volunteers. Thirty minutes after excess drug removal, skin inflammation was induced by a 1-min application of methyl nicotinate (3 mM). This was repeated 44 h later. Each methyl-nicotinate application was followed by continuous skin blood flow recordings over 1 h. Overall, NSAIDs proved more effective than corticosteroids in inhibiting methyl-nicotinate-induced increases in skin blood flow. Diclofenac and indomethacin showed a potent prolonged inhibitory effect. Different types of activity were observed in the corticosteroid group: (a) At 30 min, hydrocortisone and hydrocortisone butyrate moderately inhibited methyl-nicotinate reactions whereas clobetasol propionate produced no detectable effects; (b) at 44 h, clobetasol propionate produced a significant inhibition whereas hydrocortisone butyrate and hydrocortisone exhibited either weak or no inhibitory action at all. These pharmacodynamic discrepancies between the corticosteroids tested could be related to differences in drug affinity to cutaneous receptors and in vasoconstrictive potency.
Subject(s)
Anti-Inflammatory Agents, Non-Steroidal/therapeutic use , Betamethasone/analogs & derivatives , Clobetasol/analogs & derivatives , Dermatitis, Contact/prevention & control , Hydrocortisone/therapeutic use , Nicotinic Acids/adverse effects , Adult , Bufexamac/therapeutic use , Clobetasol/therapeutic use , Diclofenac/therapeutic use , Humans , Hydrocortisone/analogs & derivatives , Ibuprofen/therapeutic use , Indomethacin/therapeutic use , Male , Niflumic Acid/therapeutic use , Phenylbutazone/therapeutic use , Regional Blood Flow/drug effects , Skin/blood supplyABSTRACT
Six groups of children suffering from widespread atopic dermatitis were treated once daily with six topical steroids of different potency. Systemic effects were measured by the morning estimation of plasma cortisol. A clear relationship was demonstrated between clinical efficacy of the steroid treatment and degree of reduced adrenal function. This study demonstrated that a rapid and marked therapeutic effect can be obtained with potent topical steroids applied once daily without occlusion, but in children is accompanied by a fall in plasma cortisol.
Subject(s)
Anti-Inflammatory Agents/therapeutic use , Dermatitis, Atopic/drug therapy , Administration, Topical , Anti-Inflammatory Agents/administration & dosage , Betamethasone/analogs & derivatives , Betamethasone/therapeutic use , Child , Child, Preschool , Clobetasol/analogs & derivatives , Clobetasol/therapeutic use , Dermatitis, Atopic/blood , Desonide/therapeutic use , Diflucortolone/therapeutic use , Drug Administration Schedule , Female , Fluocortolone/analogs & derivatives , Fluocortolone/therapeutic use , Halcinonide/therapeutic use , Humans , Hydrocortisone/blood , Infant , Male , OintmentsSubject(s)
Dermatitis, Atopic/drug therapy , Glycyrrhetinic Acid/administration & dosage , Adolescent , Child , Child, Preschool , Female , Humans , Infant , Male , OintmentsABSTRACT
Los autores estudiaron los parametros clinicos de 300 casos de ninos con dermatitis atopicas de acuerdo a um programa informatico. Se trata del primer estudio de este tipo y aunque este programa se considera como un paso preliminar a la investigacion bioclinica de la dermatitis atopica permite senalar las inexactitudes de muchos conceptos corrientemente ensenados
Subject(s)
Infant, Newborn , Infant , Child, Preschool , Child , Humans , Dermatitis, AtopicABSTRACT
Los autores estudiaron los parametros clinicos de 300 casos de ninos con dermatitis atopicas de acuerdo a um programa informatico. Se trata del primer estudio de este tipo y aunque este programa se considera como un paso preliminar a la investigacion bioclinica de la dermatitis atopica permite senalar las inexactitudes de muchos conceptos corrientemente ensenados
