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ent-Trachylobane diterpenoids from Xylopia langsdorffiana.
Tavares, Josean Fechine; Queiroga, Karine F; Silva, Marianna Vieira B; Diniz, Margareth F F M; Filho, José M B; da-Cunha, Emidio V L; de Simone, Carlos Alberto; Júnior, João X de Araújo; Melo, Patrícia S; Haun, Marcela; da Silva, Marcelo Sobral.
J Nat Prod ; 69(6): 960-2, 2006 Jun.
Article in English | MEDLINE | ID: mdl-16792419

ABSTRACT

Two new diterpenes of the ent-trachylobane type were isolated from the stems of Xylopia langsdorffiana, ent-7alpha-acetoxytrachyloban-18-oic acid (1) and ent-7alpha-hydroxytrachyloban-18-oic acid (2). The structures of these isolates were deduced by spectroscopic data interpretation. X-ray crystallography of 1 was used to confirm its structure. The cytotoxic activity of 1 against V79 fibroblasts and rat hepatocytes was investigated.


Subject(s)
Annonaceae/chemistry , Diterpenes , Plants, Medicinal/chemistry , Animals , Brazil , Crystallography, X-Ray , Diterpenes/chemistry , Diterpenes/classification , Diterpenes/isolation & purification , Diterpenes/pharmacology , Fibroblasts/drug effects , Hepatocytes/drug effects , Male , Molecular Conformation , Molecular Structure , Plant Stems/chemistry , Rats , Rats, Wistar
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