Subject(s)
Peritonitis/diagnostic imaging , Appendix , Cecal Diseases/complications , Female , Humans , Infant , Peritonitis/etiology , RadiographySubject(s)
Ileal Diseases/diagnostic imaging , Intussusception/diagnostic imaging , Lymphatic Diseases/etiology , Child , Diagnosis, Differential , Female , Humans , Ileal Diseases/complications , Intussusception/complications , Lymphatic Diseases/diagnostic imaging , Meckel Diverticulum/complications , Mesentery/pathology , Radiography , UltrasonographyABSTRACT
We have studied retrospectively a series of 10 children presenting with chronic multifocal osteomyelitis (8 girls, 2 boys, 7 to 16 years). All patients had plain films, bone scintigraphies and histological studies. Three had CT scan and/or MRI. compared with literature data, we observed only one case of palmoplantar pustulosis and only 2 cases of lysis of the medial extremity of the clavicle; in addition, we report one case of lateral extremity of the clavicle and 2 vertebral locations. The radiological pattern was typical: at the beginning of the disease, plain films showed lytic areas which became progressively osteosclerotic with enlargement of the bone. In all the cases, bone scintigraphy revealed high uptake areas which were often infraclinical. The diagnosis was delayed from 3 months to 3 years. This emphasizes the difficulty of the diagnosis which relies on the association of clinical, biological and radiological elements. Biopsies are required to rule out an infectious bacterial osteomyelitis or a tumoral process. The pathogenesis of OCMR remains unknown, but the relation with the SAPHO (synovitis, acne, pustulosis, hyperostosis, osteitis) syndrome is general accepted because of the similar features of the osteitis. The long term follow up appears to be uncertain 6 of our patients are still symptomatic after five years despite anti inflammatory treatment.
Subject(s)
Osteomyelitis/diagnostic imaging , Adolescent , Age Factors , Child , Chronic Disease , Female , Humans , Male , Osteomyelitis/diagnosis , Osteomyelitis/physiopathology , Radiography , Recurrence , Retrospective Studies , Time FactorsABSTRACT
A kindred of four children of different ages was at the same time adopted and transferred from a very poor to a fairly good environment. A rapid catch-up growth was observed in all four during the first 2 years after adoption. Beyond the 2nd year, physical development varied according to age, sex, and the rhythm of sexual maturation. Puberty was not advanced. Final height depended mainly on the height at the onset of puberty. The homogeneity of this familial story can contribute to a better understanding of the age-related interactions between the nutritional and environmental conditions and the genetic factors in human development. The growth and puberty of children coming from poor areas of the world to be fostered in families living in industrialized countries may shed some light on the role of nutritional and environmental factors in human development.
