1.
Org Biomol Chem
; 9(14): 5104-8, 2011 Jul 21.
Article
in English
| MEDLINE
| ID: mdl-21617813
ABSTRACT
A tag removal-cyclisation sequence is described that is initiated by reduction using a Sm(II) species and completed by a Sm(III) Lewis acid that is formed in an earlier stage. Therefore, the reaction cascade utilises both oxidation states of a samarium reagent in discrete steps and allows access to privileged, pyrrolidinyl-spirooxindole scaffolds and analogues inspired by the anti-cancer natural product spirotryprostatin A.