ABSTRACT
The association between diabetes mellitus and hypokinetic cardiomyopathy is frequent. We report a case of diabetes and hypokinetic cardiopathy in a 40-year-old man which led to the hypothesis of maternally inherited diabetes and deafness (MIDD) due to a mitochondrial disease. This diagnosis was confirmed by genetic testing which showed a DNA A3243G mutation in the mitochondria, the prevalence of which is 1-2% in diabetes mellitus. Cardiac abnormalities are frequent (18-34% of patients depending on the series) and the co-existence of left ventricular hypertrophy and systolic dysfunction is suggestive of this disease. Some authors have proposed co-enzyme Q as a treatment to improve the left ventricular ejection fraction and insulin secretion.
Subject(s)
Cardiomyopathy, Dilated/diagnosis , Diabetes Mellitus/diagnosis , Diabetes Mellitus/genetics , Mitochondrial Diseases/diagnosis , Adult , Cardiomyopathy, Dilated/genetics , DNA Mutational Analysis , DNA, Mitochondrial/genetics , Deafness/diagnosis , Deafness/genetics , Diagnosis, Differential , Echocardiography , Genes, Mitochondrial/genetics , Humans , Image Processing, Computer-Assisted , Magnetic Resonance Imaging , Male , Mitochondrial Diseases/genetics , SyndromeABSTRACT
We report the case of a 41-year-old woman, non-smoker, without cardiovascular risk, hospitalised for acute ST elevation myocardial infarction. The coronarography showed no significant coronary stenosis and a methylergometrine test performed was positive. After the discovery of a moderate chronic hypereosinophilia, a review of the literature about eosinophile and coronary pathology was realised in order to make a link between hypereosinophilia and coronary spasm.
