ABSTRACT
A heme-iron concentrate product derived from swine hemoglobin was used to enrich the chocolate-flavored filling of biscuits and the bioavailability of this source of heme-iron was assessed in adolescent girls. The placebo control (PC) group consisted of 35 teenagers with the highest baseline hemoglobin concentrations. The supplemented groups were randomized to receive biscuits fortified with iron sulfate (IS, n = 37) or heme-iron concentrate (HIC, n = 40). Both groups were supplemented with 10.3 mg Fe/d for 7 wk. Blood chemistry and hematology analyses were performed at baseline and at the end of the study. The baseline prevalence of anemia (hemoglobin <12 g/dl) in the entire group was 3.9% and by the end of the study it had fallen to 2.3%. The hemoglobin levels in both supplemented groups increased (P < 0.05) during the study period from 13.6 and 13.5 g/dl for HIC and IS, respectively, at baseline to 14 g/dl at the end of the study. Serum ferritin concentrations decreased by the end of the study in both the PC and IS groups (P < 0.05), but not in the heme group. In conclusion, iron bioavailability from HIC-fortified biscuits was calculated to be 23.7% higher than that observed for IS, as shown by the differences observed in serum ferritin levels during the study. The iron contained in the heme-iron concentrate was well absorbed and tolerated by the adolescents included in the study.
Subject(s)
Food, Fortified , Heme/administration & dosage , Iron/pharmacokinetics , Adolescent , Anemia, Iron-Deficiency/blood , Anemia, Iron-Deficiency/drug therapy , Animals , Biological Availability , Child , Double-Blind Method , Female , Food Handling/methods , Food, Fortified/analysis , Hematologic Tests , Heme/isolation & purification , Heme/therapeutic use , Hemoglobins/analysis , Hemoglobins/chemistry , Humans , Iron/blood , Iron/therapeutic use , Mexico , Rural Population , Sus scrofaABSTRACT
Fundamento: El déficit de hierro es la carencia nutricionalmás frecuente en el mundo. Afecta principalmente a niñosy mujeres en edad fértil, especialmente a embarazadas.Se han implementado múltiples estrategias paracombatirla pero el problema persiste. Una alternativa esel uso de esquemas de suplementación intermitente queaunque controvertido, ha dado resultados positivos.Objetivo: Evaluar la utilidad de la suplementación conhierro en dosis única semanal en mujeres embarazadas.Materiales y métodos: Se comparó la concentración dehemoglobina en sangre de 107 mujeres embarazadasque siguieron dos esquemas de suplementación con hierro:dosis única semanal y dosis diaria. Se realizarondeterminaciones basales y finales de hemoglobina.Resultados: La concentración de hemoglobina final (despuésde 10 semanas de suplementación) en el total demujeres embarazadas, fue similar a la basal (P>0,05).En cambio en las anémicas (n=20), hubo un incrementoestadísticamente significativo (P0,05).Conclusiones: El comportamiento fue similar en los dosgrupos de estudio: la dosis única semanal de hierro fuetan efectiva como la diaria en la prevención y correcciónde esta deficiencia en embarazadas
Introduction: Iron Deficit is the most frequent nutritionaldeficiency in the world, affecting primarily children andwomen of fertile age especially pregnant women. Manystrategies have been implemented to try to combat thisproblem, however the problem persists. One alternative isthe use of intermittent supplementation programs, whichalthough controversial, has produced positive results.Objective: To assess the usefulness of iron supplementationin the form of a single weekly dose in pregnant women.Material and methods: Two different iron supplementationschemes were used on a total of 107 pregnant women -asingle, weekly dose and a daily dose- and the level ofhemoglobin in their blood was compared. Assessmentsof hemoglobin level were carried out at the start and endof the study.Results: The final level of hemoglobin (after ten weeks ofsupplementation) in the total number of pregnant womenwas similar to the basal one (P>0.05) except in the caseof the anemic members of the group (n=20) who showeda statistically significant increase (P0.05).Conclusions: The response was similar in the two studygroups: the single, weekly dose of iron supplementationwas as effective as the daily one in the prevention andcorrection of this deficiency in pregnant women
