ABSTRACT
Este documento presenta una exhaustiva verificación de los sistemas de blindaje en un servicio de terapias radiometabólicas, ubicada en el cuarto piso del edificio de Medicina Nuclear. En esta área, se llevan a cabo terapias con I 131 , Lu177 y Ra223 al menos tres veces por semana, atendiendo a un promedio de 60 pacientes al mes, de los cuales aproximadamente 15 son tratados con terapias de baja actividad. Todo esto se realiza en estricto cumplimiento de los límites de dosis establecidos para la zona, los horarios de ocupación, los puntos de control y el equipo de medición correspondiente. La metodología propuesta está diseñada para abordar las necesidades prácticas de los centros de terapias radiometabólicas en su funcionamiento diario, considerando las condiciones reales de exposición. Los resultadosconfirman la idoneidad de los sistemas de blindaje, adaptados específicamente a las actividades desarrolladas en estas instalaciones
This document presents an exhaustive verification of shielding systems in a radiometabolic therapy service, located on the fourth floor of the Nuclear Medicine building. In this area, therapies with I 131, Lu177 and Ra223 are carried out at least three times a week, serving an average of 60 patients per month, of which approximately 15 are treated with low-activity therapies. All this is carried out in strict compliance with the dose limits established for the zone, the occupation times, the control points and the corresponding measurement equipment. The proposed methodology is designed to address the practical needs of radiometabolic therapy centers in their daily operation, considering real exposure conditions. The results confirm the suitability of the shielding systems, specifically adapted to the activities carried out in these installations
Subject(s)
Radiation Monitoring/methods , Nuclear MedicineABSTRACT
Several studies have described that quinoid rings with electron-rich olefins at remote position experience changes in their redox potential. Since the original description of these changes, different approaches have been developed to describe the properties of the binding sites of ubiquinones. The origin of this phenomenon has been attributed to lateral chain flexibility and its effect on the recognition between proteins and substrates associated with their important biological activity. The use of electrochemical-electron spin resonance (EC-ESR) assays and theoretical calculations at MP2/6-31G(d,p) and MP2/6-31++G(d,p)//MP2/6-31G(d,p) levels of several conformers of perezone [(2-(1,5-dimethyl-4-hexenyl)-3-hydroxy-5-methyl-1,4-benzoquinone] established that a weak pi-pi interaction controls not only the molecular conformation but also its diffusion coefficient and electrochemical properties. An analogous interaction can be suggested as the origin of similar properties of ubiquinone Q10. The use of nuclear magnetic resonance rendered, for the first time, direct evidence of the participation of different perezone conformers in solution and explained the cycloaddition process observed when the aforementioned quinone is heated to form pipitzols, sesquiterpenes with a cedrene skeleton. The fact that biological systems can modulate the redox potential of this type of quinones depending on the conformer recognized by an enzyme during a biological transformation is of great relevance.
Subject(s)
Quinones/chemistry , Binding Sites , Electron Spin Resonance Spectroscopy , Electrons , Magnetic Resonance Spectroscopy , Models, Molecular , Molecular Conformation , Oxidation-Reduction , Sesquiterpenes/chemistry , SolutionsABSTRACT
El presente documento es un instrumento de prevención de la rabia cuyo objetivo es ayudar a los profesores a desarrollar una buena explicación sobre qué es la rabia, cómo se contagia, cuáles sus síntomas o malestares y cuál la forma de prevención para evitar muertes en la población
