ABSTRACT
Vitamin K (VK) is a fat-soluble vitamin necessary for fish metabolism and health. VK stability as dietary component during aquafeed storage and its potential effect on intestinal microbiome in fish have not yet been completely elucidated. The convenient storage conditions of aquafeeds when supplemented with phylloquinone (VK1), as well as its potential effects on the gut microbiota of Senegalese sole (Solea senegalensis) juveniles, have been explored. Experimental feeds were formulated to contain 0, 250 and 1250 mg kg-1 of VK1 and were stored at different temperatures (4, -20 or -80 °C). VK stability was superior at -20 °C for short-term (7 days) storage, while storing at -80 °C was best suited for long-term storage (up to 3 months). A comparison of bacterial communities from Senegalese sole fed diets containing 0 or 1250 mg kg-1 of VK1 showed that VK1 supplementation decreased the abundance of the Vibrio, Pseudoalteromonas, and Rhodobacterace families. All these microorganisms were previously associated with poor health status in aquatic organisms. These results contribute not only to a greater understanding of the physiological effects of vitamin K, particularly through fish intestinal microbiome, but also establish practical guidelines in the industry for proper aquafeed storage when supplemented with VK1.
ABSTRACT
Resumen El síndrome de Li-Fraumeni (SLF) es un trastorno autosómico dominante hereditario con predisposición al cáncer, está asociado con anomalías en el gen de la proteína tumoral p53 (TP53), que se manifiesta por una amplia gama de neoplasias malignas que aparecen a una edad temprana. Se expone al caso de un adulto joven en quien hicimos este diagnóstico, y se describen las perspectivas terapéuticas en investigación. (Acta Med Colomb 2022; 47. DOI:https://doi.org/10.36104/amc.2022.2198).
Abstract Li-Fraumeni syndrome (LFS) is a hereditary autosomal dominant disorder with a predisposition to cancer. It is associated with abnormalities of the tumor protein p53 (TP53) gene, manifesting with a broad range of malignant neoplasms which appear at an early age. We discuss the case of a young adult in whom we did this diagnosis, and we describe the therapeutic perspectives being researched. (Acta Med Colomb 2022; 47. DOI:https://doi.org/10.36104/amc.2022.2198).
ABSTRACT
INTRODUCTION: Situs inversus totalis (SIT) is an autosomal recessive congenital disorder. Acute cholecystitis is a diagnosis challenge in patients with SIT. CLINICAL CASE: A 26-year-old female who presented with atypical gallbladder colic. Assessed by Surgery, concluding diagnosis of acute cholecystitis and SIT. Laparoscopic cholecystectomy was performed. DISCUSSION: SIT is a rare congenital pathology, defined by the transposition of thoracic and abdominal viscera. Most patients are asymptomatic and they're discovered incidentally. The SIT goes far beyond the paradigm of treatments and surgical techniques. CONCLUSIONS: The pathology turns into a behavior modification for surgical treatment, however, it is possible to carry them out successful procedure.
INTRODUCCIÓN: El situs inversus total (SIT) es un trastorno congénito autosómico recesivo. La colecistitis aguda es un reto diagnóstico en los pacientes con SIT. CASO CLÍNICO: Mujer de 26 años con cólico vesicular atípico. Valorada por cirugía, se concluye el diagnóstico de colecistitis aguda y SIT. Se realiza colecistectomía laparoscópica, sin complicaciones. DISCUSIÓN: En el SIT definido por transposición de vísceras torácicas y abdominales, la mayoría de los pacientes son asintomáticos y se descubre incidentalmente. El SIT supera el paradigma de tratamientos y técnicas quirúrgicas. CONCLUSIONES: Esta patología requiere modificación de conductas para el tratamiento quirúrgico, pero es posible realizarlo con éxito.
Subject(s)
Cholecystectomy, Laparoscopic , Cholecystitis, Acute , Situs Inversus , Abdomen , Adult , Cholecystitis, Acute/complications , Cholecystitis, Acute/surgery , Female , Humans , Situs Inversus/complications , Situs Inversus/surgeryABSTRACT
The bronze bug, Thaumastocoris peregrinus, an Australian native insect, has become a nearly worldwide invasive pest in the last 16 years and has been causing significant damage to eucalypts (Myrtaceae), including Eucalyptus spp. and Corymbia spp. Its rapid expansion leads to new questions about pathways and routes that T. peregrinus used to invade other continents and countries. We used mtDNA to characterize specimens of T. peregrinus collected from 10 countries where this species has become established, including six recently invaded countries: Chile, Israel, Mexico, Paraguay, Portugal, and the United States of America. We then combined our mtDNA data with previous data available from South Africa, Australia, and Europe to construct a world mtDNA network of haplotypes. Haplotype A was the most common present in all specimens of sites sampled in the New World, Europe, and Israel, however from Australia second more frequently. Haplotype D was the most common one from native populations in Australia. Haplotype A differs from the two major haplotypes found in South Africa (D and G), confirming that at least two independent invasions occurred, one from Australia to South Africa, and the other one from Australia to South America (A). In conclusion, Haplotype A has an invasion success over many countries in the World. Additionally, analyzing data from our work and previous reports, it is possible to suggest some invasive routes of T. peregrinus to predict such events and support preventive control measures.
Subject(s)
Heteroptera/genetics , Animals , Asia , Australia , DNA, Mitochondrial/genetics , Electron Transport Complex IV/chemistry , Electron Transport Complex IV/genetics , Europe , Genetic Variation , Haplotypes , Insect Proteins/chemistry , Insect Proteins/genetics , North America , South AmericaABSTRACT
En el hospital de SOLCA y Hospital Vozandes de Quito, Ecuador, se realizó una investigación prospectiva, comparativa y multicéntrica para elvaluar la premedicación anestésica con ketamina o midazolam, administrados por vía rectal, en veinte pacientes pediátricos. Los parámetros considerados fueron: tolerancia a la vía de administración, tranquilidad, sedación, respuesta al dolor, requerimiento de gases anestésicos, estabilidad hemodinámica, despertar y efectos secundarios. Se demuestra la ventaja de estos fármacos administrados por vía rectal en cuanto a su tolerancia, ambos resultados útiles para los fines propuestos, existen diferencias en cuanto al requerimiento de gases anestésicos y a la rapidez del despertar. Los efectos secundarios fueron mínimos e infrecuentes con ambas drogas.
Subject(s)
Humans , Administration, Rectal , Anesthesia , Midazolam/administration & dosage , Pediatrics , PremedicationABSTRACT
La atar analgesia fue descrita como técnica anestésica que aprovechaba los efectos ataráxicos de una combinación medicamentosa a base de benzodiacepínicos, analgésicos y relajantes musculares. El resultado más importante de este procedimiento consiste en la pronta recuperación, pero la intubación endotraqueal y la descurarización son pasos imprescindibles. En el Instituto de la Sociedad de Lucha contra el Cáncer (S.O.L.C.A) de Quito-Ecuador, hemos implementado una técnica que aprovecha la capacidad analgésica del procedimiento, en la realización de 25 intervenciones quirúrgicas cortas. No hemos empleado relajantes musculares ni tampoco intubación endotraqueal. Todos los pacientes fueron sometidos a un protocolo prospectivo-comparativo. El grupo control fue sometido a anestesia raquídea o peridural. Los beneficios de nuestra técnica fueron superiores a los de este grupo.
