ABSTRACT
A series of 27 new barbiturates and thiobarbiturates have been synthesized by a convenient multi-component reaction in overall excellent yields (87-96%). All the synthesized compounds were characterized by 1H, 13C NMR, EIMS and elemental analysis (C, H, N and S). Furthermore, all compounds were screened for in vitro antioxidant (DPPH radical scavenging), lipoxygenase, chymotrypsin, α-glucosidase and anti-urease activities. Out of the series, 23 in DPPH, 14 in lipoxygenase, 2 in chymotrypsin have shown appreciable IC50 values.
Subject(s)
Antioxidants/chemical synthesis , Barbiturates/chemical synthesis , Enzyme Inhibitors/chemical synthesis , Thiobarbiturates/chemical synthesis , Antioxidants/chemistry , Barbiturates/chemistry , Biphenyl Compounds/antagonists & inhibitors , Chymotrypsin/antagonists & inhibitors , Chymotrypsin/chemistry , Enzyme Assays , Enzyme Inhibitors/chemistry , Lipoxygenase/chemistry , Picrates/antagonists & inhibitors , Thiobarbiturates/chemistry , Urease/antagonists & inhibitors , Urease/chemistry , alpha-Glucosidases/chemistryABSTRACT
In the title compound, C(18)H(17)N(3)O(4), the furyl and phenyl rings are inclined at almost right angles [85.77â (7) and 63.25â (7)°, respectively] to the central imidazo[1,2-a]pyridinyl unit. The structure displays both inter- and intra-molecular N-Hâ¯O hydrogen bonding.
ABSTRACT
In the title compound, C(19)H(18)FN(3)O(4), the fused pyridine and pyrimidine rings adopt half-chair conformations. The structure displays intra-molecular N-Hâ¯O and inter-molecular N-Hâ¯F hydrogen bonding.
