ABSTRACT
Nitric oxide (NO) is a gaseous free radical endogenously generated in plant cells. Peroxisomes are cell organelles characterized by an active metabolism of reactive oxygen species (ROS) and are also one of the main cellular sites of NO production in higher plants. In this mini-review, an updated and comprehensive overview is presented of the evidence available demonstrating that plant peroxisomes have the capacity to generate NO, and how this molecule and its derived products, peroxynitrite (ONOOâ») and S-nitrosoglutathione (GSNO), can modulate the ROS metabolism of peroxisomes, mainly throughout protein posttranslational modifications (PTMs), including S-nitrosation and tyrosine nitration. Several peroxisomal antioxidant enzymes, such as catalase (CAT), copper-zinc superoxide dismutase (CuZnSOD), and monodehydroascorbate reductase (MDAR), have been demonstrated to be targets of NO-mediated PTMs. Accordingly, plant peroxisomes can be considered as a good example of the interconnection existing between ROS and reactive nitrogen species (RNS), where NO exerts a regulatory function of ROS metabolism acting upstream of H2O2.
ABSTRACT
Desde la mitad de los años treinta del siglo pasado, se ha considerado erróneamente que la Aspirina había sido descubierta por Felix Hoffmann, sin embargo recientes estudios reconocen a Arthur Eichengrün como el autor más importante. En este artículo se describe una breve historia del fármaco y cómo las pasiones políticas la modificaron
From the thirties of last century, the Aspirin has been wrongly considered as a Felix Hoffmann discovering. Nevertheless, recent research has put in evidence that the true inventor of this drug has been Arthur Eichengrün. In this paper, a short history of the drug is described, as well as the political interferences on it
