ABSTRACT
In this paper, we introduce a novel type of transdermal drug delivery device (TD3) with a micro-electro-mechanical system (MEMS) design using computer-aided design (CAD) techniques as well as computational fluid dynamics (CFD) simulations regarding the fluid interaction inside the device during the actuation process. For the actuation principles of the chamber and microvalve, both thermopneumatic and piezoelectric principles are employed respectively, originating that the design perfectly integrates those principles through two different components, such as a micropump with integrated microvalves and a microneedle array. The TD3 has shown to be capable of delivering a volumetric flow of 2.92 × 10-5 cm3/s with a 6.6 Hz membrane stroke frequency. The device only needs 116 Pa to complete the suction process and 2560 Pa to complete the discharge process. A 38-microneedle array with 450 µm in length fulfills the function of permeating skin, allowing that the fluid reaches the desired destination and avoiding any possible pain during the insertion.
Subject(s)
Drug Delivery Systems/instrumentation , Equipment Design/instrumentation , Micro-Electrical-Mechanical Systems/instrumentation , Administration, Cutaneous , Computer-Aided Design/instrumentation , Humans , Microinjections/instrumentation , Needles , Pharmaceutical Preparations/administration & dosage , Skin/drug effectsABSTRACT
Este trabajo constituye un diagnóstico situacional de tipo internacional, a partir de los resultados obtenidos en la investigación aplicada a través de encuesta, con un muestreo de la población de mujeres que se encuentran en las etapas pre-natal y post-natal que asisten al Hospital Materno- Infantil de la Caja Nacional de Salud, ademas del personal de salud de dicho hospital y que trabaja en este campo; con el propósito de contar con un estudio cientifico, que revele el nivel de conocimiento y necesidad de un programa completo e integral de preparación al parto y al post-parto para luego elaborar dicho programa y presentar como una propuesta que será puesta en práctica en centros de salud en la ciudad de La Paz...
