1.
P R Health Sci J
; 13(1): 13-5, 1994 Mar.
Article
in English
| MEDLINE
| ID: mdl-8016289
ABSTRACT
A glucosidase inhibition assay has been used to evaluate extracts from higher plants. An enzyme inhibition of fifty percent or more correlated with the observed cytotoxicity of the extracts.
Subject(s)
Drug Evaluation, Preclinical/methods , Plant Extracts/pharmacology , beta-Glucosidase/antagonists & inhibitors , Antiviral Agents/pharmacology , Cell Death/drug effects , HIV/drug effects , Lymphocytes/drug effects , Plant Extracts/toxicity , Puerto Rico
2.
P R Health Sci J
; 13(1): 17-8, 1994 Mar.
Article
in English
| MEDLINE
| ID: mdl-7517050
ABSTRACT
Extracts from higher plants were evaluated for inhibitory activity against avian myeloblastosis virus reverse transcriptase. The assay may serve as a useful prescreen for potential anti-HIV bioactives.
Subject(s)
Antiviral Agents/pharmacology , Drug Evaluation, Preclinical/methods , Plant Extracts/pharmacology , Reverse Transcriptase Inhibitors , Avian Myeloblastosis Virus/enzymology , HIV/drug effects , Puerto Rico
3.
J Nat Prod
; 56(8): 1423-5, 1993 Aug.
Article
in English
| MEDLINE
| ID: mdl-8229020
ABSTRACT
From the bulbs and leaves of Hymenocallis expansa (Amaryllidaceae), three alkaloid constituents were identified: (+)-tazettine, (+)-hippeastrine, and (-)-haemanthidine. These alkaloids demonstrated significant cytotoxicity when tested against a panel of human and murine tumor cell lines.
