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New cationic polyprenyl derivative proposed as a lipofecting agent.

Madeja, Zbigniew; Rak, Monika; Wybieralska, Ewa; Rózanski, Igor; Masnyk, Marek; Chmielewski, Marek; Lysek, Robert; Chojnacki, Tadeusz; Jankowski, Wieslaw; Ciepichal, Ewa; Swiezewska, Ewa; Tekle, Michael; Dallner, Gustav.

Acta Biochim Pol ; 54(4): 873-6, 2007.

Article in English | MEDLINE | ID: mdl-18066397

ABSTRACT

Cationic linear poly-cis-isoprenoid prepared from natural plant polyprenol in a mixture with dioleyl phosphatidylethanolamine was found to be an effective lipofection agent for eukaryotic cells. The transfecting activity is related to the poly-cis structure of the polyprenyl chain.

Subject(s)

Lipids/chemistry , Neoprene/chemistry , Transfection , Cations , Cell Line, Tumor , Humans , Male , Molecular Structure , Phosphatidylethanolamines/chemistry , Plants/chemistry

ABSTRACT

Subject(s)

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