1.
Bioorg Med Chem Lett
; 24(5): 1269-73, 2014 Mar 01.
Article
in English
| MEDLINE
| ID: mdl-24513046
ABSTRACT
A series of lactam sulfonamides has been discovered and optimized as inhibitors of the Kv1.5 potassium ion channel for treatment of atrial fibrillation. In vitro structure-activity relationships from lead structure C to optimized structure 3y are described. Compound 3y was evaluated in a rabbit PD-model and was found to selectively prolong the atrial effective refractory period at submicromolar concentrations.