ABSTRACT
Twenty-nine children with atopic dermatitis, 4 to 9 years of age, were included in an open study of the analgesic efficacy and the application-site reactions produced by EMLA cream 5% at a maximum dose of 10 g applied for 30 minutes under occlusion prior to the curettage of molluscum contagiosum. Molluscum areas with and without eczema were treated. The overall magnitude of pain was assessed first by the child and then by the physician on a four-step verbal rating scale immediately after completion of the curettage. Prior to the surgical treatment, the application site was examined for local skin reactions. Eighty-three percent of the children rated the pain from the surgical procedure as none or mild, while the physicians rated the pain as none or mild in 86% of the children. The application-site reactions were pallor, redness, and edema. These reactions were transient and required no clinical attention. Their incidence or severity did not differ significantly between areas with and without eczema. In conclusion, EMLA cream 5% applied for 30 minutes under an occlusive dressing provides effective local analgesia without serious application-site reactions for the curettage of molluscum contagiosum in children with atopic dermatitis.
Subject(s)
Anesthetics, Combined/administration & dosage , Anesthetics, Local/administration & dosage , Curettage/methods , Dermatitis, Atopic/complications , Lidocaine/administration & dosage , Molluscum Contagiosum/surgery , Pain/prevention & control , Preoperative Care/methods , Prilocaine/administration & dosage , Anesthetics, Combined/adverse effects , Anesthetics, Local/adverse effects , Child , Child, Preschool , Female , Humans , Lidocaine/adverse effects , Lidocaine, Prilocaine Drug Combination , Male , Occlusive Dressings , Ointments , Pain/etiology , Prilocaine/adverse effects , Time FactorsSubject(s)
Acne Vulgaris/drug therapy , Tretinoin/therapeutic use , Adult , Clinical Trials as Topic , Humans , Isotretinoin , Male , Tretinoin/adverse effectsABSTRACT
During a trial of isotretinoin (0.5 mg/kg body weight/day for 3 months) in 90 patients with severe acne, the leucocyte (WBC) count, and particularly the number of neutrophils, decreased significantly. In patients with a good response the mean WBC count fell by 24% and the neutrophils by 33%, whereas in those with a poor response these variables decreased by 8% and 14%, respectively. The serum ALAT, ASAT, cholesterol and triglyceride levels increased significantly. Patients with a poor response (n = 35) received a higher dosage (0.75 mg/kg) for an additional 3 months, and during this period there was a further decrease in the WBC and neutrophil counts and an increase in the triglyceride level. In the other patients, who initially responded well, the dosage was decreased to 0.1 or 0 mg/kg during the second 3-month period, which resulted in reversion of the laboratory variables to the pre-treatment levels. The observed changes were clearly both dose-dependent and reversible.
Subject(s)
Acne Vulgaris/drug therapy , Tretinoin/therapeutic use , Adolescent , Adult , Alanine Transaminase/blood , Aspartate Aminotransferases/blood , Cholesterol/blood , Clinical Trials as Topic , Dose-Response Relationship, Drug , Female , Humans , Isotretinoin , Leukocyte Count/drug effects , Male , Tretinoin/administration & dosage , Tretinoin/adverse effects , Triglycerides/bloodABSTRACT
In the present study 46 patients with severe psoriasis maintained on long-term PUVA therapy have been followed up to 6 1/2 years after the initiation of treatment. Repeated ophthalmological examinations were performed in order to detect any early sign of lens changes. No ocular side effects attributed to the photochemotherapy were revealed during this period. Continued use of appropriate eye shielding is recommended and also routines to remind patients to actually wear their protective glasses.
Subject(s)
Eye/drug effects , PUVA Therapy/adverse effects , Photochemotherapy/adverse effects , Psoriasis/drug therapy , Adult , Aged , Eye Diseases/diagnosis , Female , Follow-Up Studies , Humans , Lens, Crystalline/drug effects , Male , Middle Aged , OphthalmologyABSTRACT
Three infant boys with a centrifugal annular erythema mainly consistent with erythema annulare centrifugum, developing a few weeks after birth, are described. The lesions disappeared before the age of 6 months, without atrophy, and during this period the infants were otherwise healthy. This group is considered to belong to one of three types of reactivity in infants associated with or expressed as a connective tissue disease, especially lupus erythematosus, in the mother and child or in either. In type 1, signs and symptoms of systemic lupus erythematosus are or will be present in the mother and the child displays discoid lupus erythematosus lesions at birth or soon after. In type 2, the mother has the same signs and symptoms as in type 1 but the child develops a centrifugal annular erythema 3-6 weeks after birth. In type 3, discoid lupus erythematosus is present at an early stage in the infant, while the mother is healthy. This type may represent an early onset of lupus erythematosus in the infants.
