ABSTRACT
The objective of these studies was to investigate genes of importance in the pathogenesis of Aspergillus infections. To do so, we employed microarray methodology to explore gene expression in human monocytes infected with Aspergillus conidia as compared with unstimulated monocytes and those stimulated with lipopolysaccharide (LPS) signaling through TOLL-like receptor 4 (TLR4). We found 997 (PSubject(s)
Aspergillus fumigatus/immunology
, Gene Expression Profiling
, Monocytes/immunology
, Gene Expression Regulation
, Humans
, Lipopolysaccharides/immunology
, Microscopy, Confocal
, Monocytes/cytology
, Monocytes/microbiology
, Oligonucleotide Array Sequence Analysis
, Phagocytosis
, RNA/analysis
, Reverse Transcriptase Polymerase Chain Reaction
, Spores, Fungal/immunology
, Toll-Like Receptor 4/analysis
