ABSTRACT
AIM: The risk of local recurrence following curative surgery for colorectal cancer (CRC) is up to 50%. A rigorous follow-up program may increase survival. Guidelines on suitable methods for scheduled follow up examinations are needed. This study evaluates a strict follow-up program including carcinogenic embryonic antigen (CEA), chest X-ray, abdominal ultrasound (US), computed tomography (CT) and (18)F-FDG positron emission tomography (FDG-PET). METHOD: A cohort of 132 patients, treated by surgery with curative intent for CRC, was included. Patients were followed prospectively with scheduled controls at 3, 6, 12 and 24 months after curative surgery. CEA, chest X-ray, US, CT and FDG-PET supplemented by clinical examination. The end-point was recurrence. Sensitivity and specificity was estimated 2 years after surgery. RESULTS: Of the 132 patients included in the study, 25 experienced recurrence, detected at scheduled controls (n = 18) and at intervals between them (n = 7). The results of CT and FDG-PET were correlated with recurrence. CT combined with FDG-PET had the highest specificity and sensitivity. CONCLUSION: A total of 72% of recurrences were detected at scheduled controls. The findings supported a strict follow-up program following curative surgery for colorectal cancer. FDG-PET combined with CT should be included in control programs.
Subject(s)
Colorectal Neoplasms/pathology , Colorectal Neoplasms/surgery , Critical Pathways , Neoplasm Recurrence, Local/diagnosis , Adult , Aged , Aged, 80 and over , Carcinoembryonic Antigen/blood , Female , Humans , Liver/diagnostic imaging , Male , Middle Aged , Neoplasm Metastasis , Physical Examination , Positron-Emission Tomography , Radiography, Abdominal , Radiography, Thoracic , Sensitivity and Specificity , Sigmoidoscopy , Tomography, X-Ray Computed , UltrasonographyABSTRACT
OBJECTIVES: An audit of treating femoro-crural bypass stenosis in the first instance by PTA. DESIGN: Prospective clinical pilot study in consecutive patients. MATERIALS: Prior to vascular bypass grafting all patients had critical ischaemia. Sixty-four PTA procedures in 50 grafts in 49 patients were carried out. Thirteen were in situ saphenous grafts, 16 were combined venous segments, 18 were combined PTFE and vein and three were PTFE only. METHODS: Conventional cross-over or antegrade PTA, eventually combined with local thrombolytic therapy. RESULTS: The nine-month assisted patency using PTA was 72%, following surgical repair in five cases after failed PTA the secondary patency was 86%. The amputation free survival rate was 88%. In 11 cases thrombosis was treated successfully with local thrombolysis. In two cases the balloon ruptured the native artery wall below the distal anastomosis with pseudoaneurysm formation. Six limbs were amputated during follow-up. The frequency of stenosis in combined grafts was significantly higher than in in situ vein grafts. CONCLUSION: Our results are comparable with surgery. About 600 hospital beds/days were saved. This shortened the time from the diagnosis of stenosis to therapy and shortened the waiting list for vascular surgery.
