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J Am Chem Soc ; 125(40): 12086-7, 2003 Oct 08.
Article in English | MEDLINE | ID: mdl-14518982

ABSTRACT

The new highly preorganized tweezer molecule 1 binds noradrenaline in polar solvents with unprecedented specificity. It uses a biomimetic recognition pattern and rejects almost all other neurotransmitters. LB experiments on a film balance reflect the same selectivity if 1 is incorporated into a stearic acid monolayer.


Subject(s)
Biomimetic Materials/chemistry , Biphenyl Compounds/chemistry , Norepinephrine/chemistry , Receptors, Adrenergic, beta/chemistry , Alkynes/chemical synthesis , Alkynes/chemistry , Biomimetic Materials/chemical synthesis , Biphenyl Compounds/chemical synthesis , Kinetics , Organophosphonates/chemistry , Phenazines/chemical synthesis , Phenazines/chemistry , Spectrometry, Mass, Electrospray Ionization
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