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Phytochemistry ; 62(4): 631-6, 2003 Feb.
Article in English | MEDLINE | ID: mdl-12560038

ABSTRACT

A new naphthylisoquinoline alkaloid, ancistrolikokine D, and the likewise 5,8'-coupled alkaloid ancistroealaine A, as well as two further, biosynthetically related, but nitrogen-free natural products, ancistronaphthoic acid B and cis-isoshinanolone, have been isolated from Ancistrocladus likoko J. LEACUTE;ONARD (Ancistrocladaceae). The 5,8'-coupling of the new alkaloids and of the alkaloids isolated earlier hints at a close phylogenetic relationship of A. likoko to other Central African Ancistrocladus species. The compounds show moderate activities against Leishmania donovani, Trypanosoma cruzi, and Trypanosoma brucei rhodesiense.


Subject(s)
Alkaloids/isolation & purification , Anti-Infective Agents/isolation & purification , Caryophyllaceae/chemistry , Isoquinolines/chemistry , Isoquinolines/isolation & purification , Naphthalenes/chemistry , Naphthols/isolation & purification , Alkaloids/chemistry , Alkaloids/pharmacology , Animals , Anti-Infective Agents/chemistry , Anti-Infective Agents/pharmacology , Biological Products/chemistry , Biological Products/isolation & purification , Biological Products/pharmacology , Cell Line , Cell Survival/drug effects , Democratic Republic of the Congo , Inhibitory Concentration 50 , Isoquinolines/pharmacology , Leishmania donovani/drug effects , Magnetic Resonance Spectroscopy , Molecular Structure , Naphthols/chemistry , Naphthols/pharmacology , Plant Roots/chemistry , Plasmodium falciparum/drug effects , Rats , Structure-Activity Relationship , Trypanosoma/drug effects
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