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1.
J Clin Exp Dent ; 9(10): e1207-e1211, 2017 Oct.
Article in English | MEDLINE | ID: mdl-29167710

ABSTRACT

BACKGROUND: The nicotine may generate a influence on bone repair and longevity of dental implants. This fact makes studies to improve the surface of the implants are constantly conducted. This study aimed to evaluate the influence of subcutaneous nicotine injection in the osseointegration process on different implant surfaces, through histomorphometric analysis. MATERIAL AND METHODS: Therefore, twenty-two male rabbits were randomly distributed into two groups according to the subcutaneous injections: (1) nicotine, 3 mg/day/kg and (2) 0.9% NaCI, 3 mL/day/kg, three times a day. Subgroups were then designated - machined and anodized dental implants were installed in the right and left tibia bones, respectively. The animals were subjected to euthanasia after periods of eight weeks for histomorphometric analysis. The bone samples with implants were removed and the routine histological processing was performed. Next, the images obtained from the blades were evaluated by the Image Tool™ software, assessing the osseointegrated areas of implants (BIC), in pixels. Data obtained were subjected to intergroup statistical analysis through the Kruskal-Wallis non-parametric test (α=5%). RESULTS: The test result showed no statistically significant difference among the groups studied (p=0.446). CONCLUSIONS: Based on the methodology studied, it is concluded that the daily application of low doses of nicotine did not interfere with the osseointegration of machined and anodized implants. Key words:Bone-implant interface, implants, osseointegration.

2.
RGO (Porto Alegre) ; 64(2): 148-153, Apr.-June 2016. tab, graf
Article in English | LILACS | ID: lil-789127

ABSTRACT

ABSTRACT Objective The objective of this experimental study was to evaluate, through bone densitometry, the performance of two factors that may influence the osseointegration process: nicotine and superficial texturization of the implants. Methods Nineteen New Zealand rabbits (Oryctolagus cuniculus) were randomly distributed in two groups (test and control), in which 38 implants were placed. 19 machined implants (flat) 3.75 mm of diameter by 6.0 mm length were placed at the right tibia of the animals and, at the left tibia, 19 anodized implants (Vulcano(r)) with the same dimensions. Subcutaneous injections of nicotine 3ml/day/kg, three times a day were administered in group, group control also received, three times a day, subcutaneous solution of NaCl (3ml/day/kg), for 8 weeks. After this period, the densitometry analysis was performed. Results Considering the optical density (pixels), there were no statistical significant differences between the types of implants (p = 0.135) as well as between groups (p=0.590). Conclusion The nicotine inside the experimental conditions used in this study and the superficial texturization of the implants indicated that they were not influencing bone density.


RESUMO Objetivo Avaliar por meio de densitometria óssea o comportamento de dois fatores que podem inteferir no processo da osseointegração: a nicotina e a texturização superficial dos implantes. Métodos Dezenove coelhos da raça Nova Zelândia (Oryctolagus cuniculus) foram distribuídos aleatoriamente em dois grupos (teste e controle), nos quais foram colocados 38 implantes. Na tíbia direita dos animais foram inseridos dezenove implantes usinados (lisos) de 3,75 mm de diâmetro por 6,0 mm de comprimento e, na tíbia esquerda, dezenove implantes anodizados (Vulcano(r)) nas mesmas dimensões. Foram administradas no grupo teste injeções subcutâneas de nicotina 3ml/dia/kg, três vezes ao dia, o grupo controle recebeu igualmente, três vezes ao dia, solução subcutânea de NaCl (3ml/dia/kg), por oito semanas. Após esse período, procedeu-se a análise densitométrica. Resultados Considerando a densidade óptica (pixels), não houve diferenças estatisticamente significativas entre os tipos de implantes (p = 0.135) bem como entre os grupos (p=0.590). Conclusão A nicotina dentro das condições experimentais empregadas neste estudo e a texturização superficial dos implantes não interferiram na densidade óssea.

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