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1.
Massive parallel RNA sequencing of highly purified mesenchymal elements in low-risk MDS reveals tissue-context-dependent activation of inflammatory programs.
Chen, S; Zambetti, N A; Bindels, E M J; Kenswill, K; Mylona, A M; Adisty, N M; Hoogenboezem, R M; Sanders, M A; Cremers, E M P; Westers, T M; Jansen, J H; van de Loosdrecht, A A; Raaijmakers, M H G P.
Leukemia ; 30(9): 1938-42, 2016 09.
Article in English | MEDLINE | ID: mdl-27109510

Subject(s)
Inflammation/genetics , Myelodysplastic Syndromes/genetics , Transcriptome , Gene Expression Profiling , Gene Regulatory Networks/genetics , Gene Regulatory Networks/immunology , High-Throughput Nucleotide Sequencing , Humans , Mesoderm/physiopathology , Myelodysplastic Syndromes/physiopathology , Sequence Analysis, RNA
2.
ATP-binding-cassette transporters in hematopoietic stem cells and their utility as therapeutical targets in acute and chronic myeloid leukemia.
Raaijmakers, M H G P.
Leukemia ; 21(10): 2094-102, 2007 Oct.
Article in English | MEDLINE | ID: mdl-17657220

ABSTRACT

ATP-binding-cassette (ABC) transporters are evolutionary extremely well-conserved transmembrane proteins that are highly expressed in hematopoietic stem cells (HSCs). The physiological function in human stem cells is believed to be protection against genetic damage caused by both environmental and naturally occurring xenobiotics. Additionally, ABC transporters have been implicated in the maintenance of quiescence and cell fate decisions of stem cells. These physiological roles suggest a potential role in the pathogenesis and biology of stem cell-derived hematological malignancies such as acute and chronic myeloid leukemia. This paper reviews the (patho)physiological role of ABC transporters in human normal and malignant HSCs and discusses its implications for their utility as therapeutical targets to eradicate leukemic stem cells in these diseases.


Subject(s)
ATP-Binding Cassette Transporters/physiology , Adenosine Triphosphate/metabolism , Gene Expression Regulation, Leukemic , Hematopoietic Stem Cells/metabolism , Leukemia, Myelogenous, Chronic, BCR-ABL Positive/metabolism , Leukemia, Myeloid, Acute/metabolism , ATP-Binding Cassette Transporters/metabolism , ATP-Binding Cassette Transporters/therapeutic use , Animals , Benzamides , Cell Differentiation , Drug Resistance, Neoplasm , Hematopoietic Stem Cells/cytology , Humans , Imatinib Mesylate , Mice , Models, Biological , Phenotype , Piperazines/pharmacology , Protein Binding , Pyrimidines/pharmacology
3.
Preferential expression of a high number of ATP binding cassette transporters in both normal and leukemic CD34+CD38- cells.
de Grouw, E P L M; Raaijmakers, M H G P; Boezeman, J B; van der Reijden, B A; van de Locht, L T F; de Witte, T J M; Jansen, J H; Raymakers, R A P.
Leukemia ; 20(4): 750-4, 2006 Apr.
Article in English | MEDLINE | ID: mdl-16467867

Subject(s)
ADP-ribosyl Cyclase 1/genetics , ATP-Binding Cassette Transporters/biosynthesis , ATP-Binding Cassette Transporters/genetics , Antigens, CD34/genetics , Gene Expression , Leukemia, Myeloid/genetics , Acute Disease , Adult , Aged , Child , Female , Humans , Leukemia, Myeloid/diagnosis , Leukemia, Myeloid/pathology , Male , Middle Aged
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