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Cancer Epidemiol Biomarkers Prev ; 17(8): 1884-90, 2008 Aug.
Article in English | MEDLINE | ID: mdl-18708376

ABSTRACT

PURPOSE: Currently, we lack biomarkers to predict whether high-risk women with mammary atypia will respond to tamoxifen chemoprevention. EXPERIMENTAL DESIGN: Thirty-four women with cytologic mammary atypia from the Duke University High-Risk clinic were offered tamoxifen chemoprevention. We tested whether ESR1 promoter hypermethylation and/or estrogen receptor (ER) protein expression by immunohistochemistry predicted persistent atypia in 18 women who were treated with tamoxifen for 12 months and in 16 untreated controls. RESULTS: We observed a statistically significant decrease in the Masood score of women on tamoxifen chemoprevention for 12 months compared with control women. This was a significant interaction effect of time (0, 6, and 12 months) and treatment group (tamoxifen versus control) P = 0.0007. However, neither ESR1 promoter hypermethylation nor low ER expression predicted persistent atypia in Random Periareolar Fine Needle Aspiration after 12 months tamoxifen prevention. CONCLUSIONS: Results from this single institution pilot study provide evidence that, unlike for invasive breast cancer, ESR1 promoter hypermethylation and/or low ER expression is not a reliable marker of tamoxifen-resistant atypia.


Subject(s)
Antineoplastic Agents, Hormonal/pharmacology , Biopsy, Fine-Needle/methods , Breast Neoplasms/genetics , Breast Neoplasms/prevention & control , Chemoprevention , DNA Methylation , Estrogen Receptor alpha/genetics , Tamoxifen/pharmacology , Adult , Antineoplastic Agents, Hormonal/administration & dosage , Breast Neoplasms/pathology , Female , Humans , Immunohistochemistry , Middle Aged , Pilot Projects , Polymerase Chain Reaction , Predictive Value of Tests , Promoter Regions, Genetic , Tamoxifen/administration & dosage , Time Factors
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