ABSTRACT
Immunologic vigor and 3-hydroxyanthranilic acid (3-HAA)-antigen level were studied in patients with urinary bladder cancer. Leukocyte migration inhibition test demonstrated the inhibitory effect of the said antigen on leukocyte migration in patients with early stage cancer. As tumor advanced, the process accelerated. The 3-HAA-antigen-containing blood serum of bladder cancer patients inhibited the synthesis of rosette-forming cells and antibodies to sheep erythrocytes. A correlation was established between the suppressive effect and tumor stage.
Subject(s)
3-Hydroxyanthranilic Acid , Antibody-Producing Cells/immunology , Antigens/immunology , Urinary Bladder Neoplasms/immunology , ortho-Aminobenzoates , Cell Migration Inhibition , Haptens , Humans , Immunoglobulins/analysis , Leukocytes/immunology , Rosette FormationSubject(s)
Embolization, Therapeutic , Kidney Neoplasms/therapy , Renal Artery , Adult , Aged , Humans , Kidney Neoplasms/blood supply , Male , Middle Aged , NephrectomyABSTRACT
Examination of the case records and histological preparations of 1150 patients with epithelial tumors of the bladder revealed urine infection with inflammation in the bladder wall in 12.1% of the cases. The inflammation not only aggravated the clinical progress of the disease but also interfere with determination of the real tumor size on cytoscopy and cystotomography. Leucocytes, macrophages, edema zones in the granulation tissue were found in great numbers in addition to the usual lympho-plasmocytal infiltration in the cases with intravesical infection in the tumor stroma and perifocally. The signs of cystic or grandular cystitis and more seldom the foci of the transitional epithelium epidermization were found at a distance of 2-4 sm from the tumor in 66.6% of the patients. The signs of the infection and inflammation disappeared after antibacterial therapy in 96.8% of the patients. It was not possible to eliminate the infection and inflammation in 1/3 of the patients with exoendophite and endophite tumors, especially in those predisposed to necrosis.
Subject(s)
Anti-Bacterial Agents/therapeutic use , Urinary Bladder Neoplasms/diagnosis , Urinary Tract Infections/drug therapy , Cystitis/drug therapy , Drug Therapy, Combination , Humans , Urinary Bladder Neoplasms/etiology , Urinary Bladder Neoplasms/pathology , Urinary Tract Infections/complicationsABSTRACT
Under study were the clinico-morphological features of epithelial tumors of the urinary bladder in 1452 patients subjected to surgery. There were differentiated three main clinico-anatomical forms of the tumor and its variants: exophitic (87.4%), endophitic (5.5%) and mixed--exophitic-endophitic ones (7.1%). The frequency and terms of recurrence were dependent on the clinico-anatomical form and stage of the tumor and its morphology. The frequency of recurrence of high-differentiated forms of the tumor made 26.9 +/- 3.0%, in low-differentiated and metaplastic forms--45--46%, in anaplastic cancer--62.8% +/- 15.4%.
