ABSTRACT
Neurofibromas of the urinary bladder occur as isolated phenomena or as part of generalized neurofibromatosis or von Recklinghausen's disease. This benign mesenchymal tumor can be the cause of subvesical obstruction, hematuria or chronic cystitis. The lesion is rare. Our case of isolated extended neurofibromatosis of the urinary bladder was diagnosed in a 19-year-old girl with an 8-year history of chronic cystitis. Two transurethral resections were successful in relieving symptoms. Possible further therapy was delayed because of the patient's desire for children.
Subject(s)
Cystitis/diagnosis , Cystitis/etiology , Neurofibromatoses/complications , Neurofibromatoses/diagnosis , Urinary Bladder Neoplasms/complications , Urinary Bladder Neoplasms/diagnosis , Adult , Cystitis/surgery , Female , Humans , Neurofibromatoses/surgery , Secondary Prevention , Treatment Outcome , Urinary Bladder Neoplasms/surgeryABSTRACT
Constricting devices placed on the penis to improve sexual performance present a challenge to urologists. Various metallic and nonmetallic objects have been described -- plumbing cuffs, bull rings, wedding rings, plastic or rubber rings -- which usually could be removed by the combination of medical and operative treatment (decompression of the penis and glandular puncture) and craftsmen's techniques. We describe the case of a titanium thumb ring of 2 mm thickness which only could be removed by using an electric cutting tool.
Subject(s)
Body Modification, Non-Therapeutic , Device Removal/instrumentation , Device Removal/methods , Penis/injuries , Titanium , Adult , Constriction, Pathologic/etiology , Constriction, Pathologic/therapy , Humans , Male , Metallurgy/methods , Orthotic Devices , Patient Care Team , Treatment Outcome , Urology/methodsABSTRACT
Mesonephric carcinoma is a tumor entity that rarely develops in the neck of the uterus and vaginal wall and is extremely unusual in the urinary bladder or paraurethral tissue. The tumors arise in the remnants of the wolffian or mesonephric duct. The malignant potential is considered to be lower than in tumors of the urethra with different histologic findings. Anterior pelvic exenteration is recommended in the literature as the treatment of choice. In the case described here, the tumor presented as a space-occupying lesion in a urethral diverticulum exhibiting striking clinical features of macrohematuria and urinary retention with subvesical obstruction of the urethra. In accordance with reports in the literature, cystectomy was performed and a Kock pouch constructed for urinary diversion. Tumors occurring in a diverticulum-and in this case manifesting as the rare tumor form of mesonephric carcinoma-should always be included in the differential diagnosis of macrohematuria in women.
Subject(s)
Hematuria/diagnosis , Mesonephroma/diagnosis , Urethral Neoplasms/diagnosis , Urethral Obstruction/diagnosis , Urinary Retention/diagnosis , Aged , Diagnosis, Differential , Female , Humans , Women's HealthABSTRACT
We describe a case of testicular duplication presenting as torsion of the supernumerary distal testis in a 14-year-old boy. Clinical examination showed an unclear mass above the left testis; intraoperatively, the supernumerary testis was linked to the regular testis by a common epididymis and shared a common vas with it. The distal testis was resected due to severe hemorrhagic damage. This condition represents the result of transversal division of the wolffian duct during organogenesis. Review of the literature revealed that testicular torsion, testicular tumor, unclear scrotal masses, or continuing potentia generandi after bilateral vasectomy were the reasons that polyorchidism was detected.
Subject(s)
Spermatic Cord Torsion/etiology , Testis/abnormalities , Adolescent , Diagnosis, Differential , Humans , Male , Regional Blood Flow/physiology , Spermatic Cord Torsion/diagnostic imaging , Spermatic Cord Torsion/pathology , Spermatic Cord Torsion/surgery , Testis/blood supply , Testis/pathology , Ultrasonography, Doppler, Duplex , Wolffian Ducts/abnormalities , Wolffian Ducts/pathologyABSTRACT
Recently, we have shown that the collagen-like, Fc-recognizing subcomponent C1q of the first complement component is synthesized by human, guinea pig and mouse peritoneal macrophages. To test whether macrophages may contribute to the serum pool of C1q, C1q was purified from guinea pig serum and from guinea pig peritoneal macrophage supernatants and compared for similarities. Both molecules had a similar sedimentation rate (macrophage C1q: 11.3 S, serum C1q: 11.2 S) and showed on sodium dodecyl sulfate-polyacrylamide gel electrophoresis under reducing conditions three identical bands with molecular weights of Mr, 29 000, Mr, 27 000 and Mr 23 000 for the A, B and C chains, respectively. Both C1q molecules migrated by immunoelectrophoresis in the gamma region and, in Ouchterlony analysis, showed complete antigenic identity with rabbit anti-serum C1q. These experiments demonstrate the antigenic and protein chemical similarities between serum C1q and C1q secreted by macrophages supporting the idea that macrophages have to be considered as one potential source of serum C1q. Furthermore, macrophage-derived C1q may be of importance in the local microenvironment at an inflammatory site involving macrophages.
Subject(s)
Complement Activating Enzymes/isolation & purification , Macrophages/analysis , Animals , Chromatography, Affinity , Complement Activating Enzymes/biosynthesis , Complement Activating Enzymes/immunology , Complement C1q , Female , Guinea Pigs , MaleABSTRACT
In this study, 26 patients were treated with 20 mg cisplatin (CP)/m2 body surface daily for 5 days as part of a combination therapy for testicular cancer. Simultaneously a vigorous hyperhydration (3000 ml daily) was applied to reduce the nephrotoxic effect induced by the drug, 131I-orthoiodohippurate clearance values obtained by the modified method of Oberhausen did not show any significant evidence of tubular dysfunction after therapy. These results may have been due to the vigorous hydration as well as to the youth of the patients.
Subject(s)
Cisplatin/adverse effects , Iodohippuric Acid , Kidney Tubules/drug effects , Radioisotope Renography , Testicular Neoplasms/drug therapy , Adult , Humans , MaleABSTRACT
An efficient method is described for the isolation of highly purified, IgG-free and stable guinea-pig serum C1q. The procedure includes the chromatography of EDTA-treated serum (25 mM EDTA) on CM- and DEAE-cellulose followed by gel filtration on ACA 34-Ultrogel whereby ammonium sulfate precipitation was used for concentration. The final product stored in a glycerol containing buffer was purified 700-fold with a yield of approximately 50%. It was judged to be homogeneous by several criteria including SDS-PAGE, analytical ultracentrifugation, gel filtration and immunoprecipitation. The protein has a sedimentation rate of 11.3 S and consists of three distinct polypeptide chains A, B and C with mol. wts of 30,200, 28,200 and 24,000. Amino acid analysis revealed a content of 4.42% hydroxyproline, 1.81% hydroxylysine and 18.7% glycine. In contrast to human serum C1q a very low content of cysteine residues was detected. SDS-PAGE analysis performed in the absence of 2-mercaptoethanol but in the presence of 5-10% SDS revealed clearly that gps-C1q is dissociated in a time-dependent manner into the individual chains.
