ABSTRACT
The authors describe a case of severe CMV retinitis in a young adult AIDS patient who recovered following first a course of ganciclovir and then HAART. Six months after the initial episode while still under successful HAART, the patient developed an acute episode of retinitis despite a persistent significant improvement in the immunological picture and a very low level of CMV reactivation. The acute episode can be related to an enhanced individual reactivity to minor CMV replication.
Subject(s)
AIDS-Related Opportunistic Infections/etiology , Antiretroviral Therapy, Highly Active , Cytomegalovirus Retinitis/etiology , HIV Infections/drug therapy , Organophosphonates , Acute Disease , Adult , Antiviral Agents/therapeutic use , CD4 Lymphocyte Count , Cidofovir , Cytosine/analogs & derivatives , Cytosine/therapeutic use , Drug Therapy, Combination , Ganciclovir/therapeutic use , Humans , Indinavir/administration & dosage , Lamivudine/administration & dosage , Male , Organophosphorus Compounds/therapeutic use , Zidovudine/administration & dosageABSTRACT
HHV-8 (Human Herpesvirus 8) is a human lymphotropic and transforming virus closely associated to the development of Kaposis's sarcoma, Castleman's disease and Primary Effusion Lymphoma among immunosuppressed patients. Prevalence of infection varies according to different geographic area and to ethnic group or to risk factors. No effective treatments are available at present.
