[The effect of gender on prevalence and survival in thyroid carcinoma]. / Vliv pohlaví na prevalenci a prezití karcinomu stítné zlázy.

Based on their own experience with a large group of patients with thyroid cancers, the authors confirm the higher prevalence of differentiated thyroid cancers both papillary and follicular (1 : 3,5) in females, while the differences in anaplastic and medullary cancers are much less prominent. Survival of females in univariate studies is much higher in both papillary and follicular cancers compared to males, in multivariate studies these differences lose their significance and only in papillary cancers under the age of 40 years at diagnosis and in a subgroup of papillofollicular cancers the differences retain their significance. The authors therefore deduce that differences found in univariate studies are significantly influenced by other factors such as age at the diagnosis and the spread of disease at the diagnosis.

Positive thyroid cancer scintigraphy using technetium-99m methoxyisobutylisonitrile.

The aim of the study was to evaluate the possibility of detecting thyroid cancer recurrences without the need for withdrawal of thyroid suppressive treatment. Upper-body or whole-body scintigraphy was performed in a group of 200 patients evaluated for differentiated thyroid cancers in 1993 and 1994 using technetium-99m sestamibi. Scans were performed 20-30min following i.v. administration of 500MBq of 99mTc-methoxyisobutylisonitrile (MIBI). Bone and lung metastases were detected with very high sensitivity and specificity, with a very high predictive value of negative results and a somewhat lower predictive value of positive results. The sensitivity and specificity of findings in the neck were lower but the predictive value of negative results was high. Whole-body scans with 99mTc-MIBI are a useful tool in the follow-up of patients with differentiated thyroid cancer, for the detection of distant metastatic lesions.

Positive thyroid cancer scintigraphy using 99Tcm-tetrofosmin (Myoview): a preliminary report.

99Tcm-tetrofosmin imaging was performed in 23 thyroid cancer patients and compared with whole-body 131I scans, neck ultrasonography and plasma thyroglobulin levels. Of 22 patients with differentiated thyroid cancer, 8 showed identical images on 131I scan and tetrofosmin; 1 patient with medullary cancer had identical images with 99Tcm-DMSA and 99Tcm-tetrofosmin, the findings being confirmed by sonography. The potential usefulness of 99Tcm-tetrofosmin imaging in the follow-up of thyroid cancers is discussed.

Alcohol dehydrogenase activity and isoenzyme distribution in the organs of cow, pig and sheep.

The highest specific activities and the most complex isoenzyme patterns were found in livers of these species, characteristic isoenzymes were observed also in the core of adrenal glands. In spite of a general resemblance the isoenzyme patterns of liver alcohol dehydrogenase are specific for the species tested; the activities in most organs (and blood sera) increase in the sequence cow, pig and sheep. The activities in foetal bovine organs are substantially lower than those in organs of adult cows, the most pronounced increase in activities during the intrauteral development was observed in liver.