1.
ACS Med Chem Lett
; 3(4): 278-83, 2012 Apr 12.
Article
in English
| MEDLINE
| ID: mdl-24900464
ABSTRACT
In this paper we describe a series of 3-cyano-5-aryl-7-aminopyrazolo[1,5-a]pyrimidine hits identified by kinase-focused subset screening as starting points for the structure-based design of conformationally constrained 6-acetamido-indole inhibitors of CK2. The synthesis, SAR, and effects of this novel series on Akt signaling and cell proliferation in vitro are described.