ABSTRACT
Seventeen duodenal ulcer patients were examined. H. pylori were detected in all the patients by histological and bacteriological methods. Changes in the enteric microflora, manifested by a decrease in the number of lacto- and bifidobacteria and by an increased level of opportunistic microflora, were established. Cimetidine treatment and the suppression of the acid-producing function of the stomach augmented enteric dysbacteriosis and H. pylori contamination of the gastric and duodenal mucosa.
Subject(s)
Duodenal Ulcer/microbiology , Gastric Acid/metabolism , Helicobacter Infections/microbiology , Helicobacter pylori , Intestines/microbiology , Adolescent , Adult , Cimetidine/therapeutic use , Duodenal Ulcer/drug therapy , Duodenal Ulcer/physiopathology , Feces/microbiology , Helicobacter Infections/drug therapy , Helicobacter Infections/physiopathology , Humans , Intestines/drug effects , Middle AgedABSTRACT
The study of the influence of cyprofloxacin on the microflora of the gastrointestinal tract has been made under experimental and clinical conditions. As revealed in this study, cyprofloxacin produces a corrective effect on the intestinal microflora; the action of this preparation, in contrast to that of other antimicrobial preparations, is retained for a long time. In patients having duodenal ulcer with bacteriosis caused by Campylobacter pylori and with intestinal dysbacteriosis the combination of cyprofloxacin and cimetidine yields a higher therapeutic effect than the use of cimetidine alone.
Subject(s)
Ciprofloxacin/pharmacology , Digestive System/drug effects , Digestive System/microbiology , Adult , Amikacin/pharmacology , Animals , Cimetidine/therapeutic use , Ciprofloxacin/therapeutic use , Dose-Response Relationship, Drug , Drug Evaluation , Drug Therapy, Combination , Duodenal Ulcer/drug therapy , Duodenal Ulcer/microbiology , Female , Germ-Free Life/drug effects , Helicobacter Infections/drug therapy , Helicobacter Infections/microbiology , Helicobacter pylori , Humans , Male , Mice , Mice, Inbred CBA , Middle Aged , Pefloxacin/pharmacology , Time FactorsABSTRACT
A total of 9 S. typhi strains and 1 S. gallinarum strain isolated from clinical material are auxotrophic with respect to tryptophan. The growth of S. typhi is accelerated in a glucose- and tryptophan-containing minimal medium with cysteine and methionine added. S. typhi strains are incapable of using sodium citrate as the only source of carbon. S. typhi cannot grow on Simmons citrate agar as these organisms are auxotrophic with respect to tryptophan and incapable of using sodium citrate as the only source of carbon, and S. gallinarum cannot grow on this medium as they are auxotrophic with respect to tryptophan.
Subject(s)
Culture Media/metabolism , Salmonella typhi/growth & development , Salmonella/growth & development , Citrates/metabolism , Citric Acid , Cysteine/metabolism , Glucose/metabolism , Humans , Methionine/metabolism , Recombination, Genetic , Salmonella/isolation & purification , Salmonella typhi/isolation & purification , Tryptophan/metabolismABSTRACT
Eight nonspecific agglutinating enterobacterial strains have been classified with the definite taxon on the basis of the data obtained by the study of their biochemical and serological properties. The possibilities offered by the supplementary methods for the study of such strains in practical laboratories are discussed.