ABSTRACT
OBJECTIVE: The aim of our study was to determine risk factors associated with nosocomial infections in children hospitalized for skin burn. STUDY DESIGN: Prospective study including children hospitalized for skin burn. METHODS: We collected demographic characteristic, mode of admission, mechanism of burn, extent of burn surface by the tables of Lund and Browder, depth of the lesions according to clinical criteria and evolution, type of invasive care (urinary catheterization, central catheterization or mechanical ventilation), nosocomial infection and its time of occurrence, prescription of empirical antibiotic therapy and evolution during hospitalization. The criteria for "American Burn Association" were used to define a severe burn in children. RESULTS: One hundred eighty-two children were included. In univariate analysis, six risk factors were significantly associated with the occurrence of nosocomial infection: extent of burn surface, severe burn, urinary catheterization and its duration and central catheterization and its duration. Extent of burn surface greater than 10% of total body surface is an independent factor of the occurrence of nosocomial infection (P=0.009) in Multivariate analysis. CONCLUSION: In our study, extent of burn surface greater than 10% of total body surface is as an independent risk factor for the occurrence of nosocomial infection.
Subject(s)
Burns/complications , Cross Infection/epidemiology , Wound Infection/epidemiology , Anti-Bacterial Agents/therapeutic use , Burns/classification , Catheter-Related Infections/drug therapy , Catheter-Related Infections/epidemiology , Catheter-Related Infections/etiology , Catheterization, Central Venous/adverse effects , Child , Child, Preschool , Cross Infection/drug therapy , Cross Infection/etiology , Female , Humans , Incidence , Infant , Male , Pneumonia, Ventilator-Associated/drug therapy , Pneumonia, Ventilator-Associated/epidemiology , Pneumonia, Ventilator-Associated/etiology , Prospective Studies , Recurrence , Risk Factors , Severity of Illness Index , Socioeconomic Factors , Tunisia/epidemiology , Urinary Catheterization/adverse effects , Wound Infection/drug therapy , Wound Infection/etiologyABSTRACT
The common prion protein gene (PRNP) codon 129 polymorphism is a strong susceptibility factor for human prion diseases. In this study, we examined the allelic variation of methionine and valine at codon 129 in 147 subjects representing the normal Moroccan population. The sharing of the genotype was 57.1% for Methionine-Methionine (MM), 36% for Methionine-Valine (MV), and 6, 8% for Valine-Valine (VV). These results are indeed intermediate between those discovered at the European and Asian populations. However, and for a better assessment of the risk to develop prion diseases in the Moroccan population, the survey of the frequency of the codon 219 polymorphism is required.
