ABSTRACT
The study investigates the cumulative impact of child maltreatment and victimization in adolescence on violent behavior in young adulthood in a nonclinical high-risk sample. The sample consists of 1,526 incarcerated young men (14 to 24 years) who were interviewed with standardized instruments during their prison term. Violent and nonviolent offenders with and without repeated victimization experiences throughout the life cycle were compared. Results show that child maltreatment doubles the risk for violent victimization in adolescence. Repeated victimization experiences in adolescence heighten the risk for later violent offending. This is the case for officially registered violence and self-reported violent behavior. In addition, child maltreatment increased the probability of self-reported violence as well. However, the interaction effect of victimization in childhood and victimization in early adolescence counteracted the main effects. Being repeatedly victimized throughout the early life cycle slightly reduced the probability of being a frequent offender.
Subject(s)
Child Abuse/psychology , Crime Victims/psychology , Juvenile Delinquency/psychology , Parent-Child Relations , Prisoners/psychology , Adolescent , Adult , Antisocial Personality Disorder/psychology , Child , Germany , Humans , Life Style , Male , Regression Analysis , Risk Factors , Surveys and QuestionnairesABSTRACT
The synthesis of a new ortho-carborane derivative, tetracarboranylketone 4, is reported here. Ketone 4 was prepared from a tetraalkynylated ketone by the addition of decaborane. The keto group was then easily modified to yield the glycosides 17alpha and 18beta, which contain glucose or galactose, respectively, and the nucleotide 13b. In addition to ketone 4, which is acyclic, cyclic ketone 8 was also synthesised. X-ray diffraction analysis of compound 4 indicated the presence of two toluene guest molecules per molecule of the host compound. Furthermore, compound 4 displays a rather low cytotoxicity. These novel products can be used as building blocks to create a new class of biomolecules containing high-density carborane clusters. Such molecules may constitute powerful tools for applications like Boron Neutron Capture Therapy or Energy-Filtering Transmission Electron Microscopy.
Subject(s)
Boron Compounds/chemistry , Boron Compounds/chemical synthesis , Boron Neutron Capture Therapy/methods , Boron/chemistry , Microscopy, Electron/methods , Pentanones/chemistry , Pentanones/chemical synthesis , Animals , Boron Compounds/toxicity , Cell Division/drug effects , Cell Line , Filtration , Glycosylation , Humans , Magnetic Resonance Spectroscopy , Molecular Conformation , Molecular Structure , Pentanones/toxicity , Rats , X-Ray DiffractionABSTRACT
We report the synthesis of new phosphoramidite building blocks and their use for the modification of oligonucleotides with hydrazides. The reaction of these hydrazide oligonucleotides with active esters and aldehydes is demonstrated for solution conjugation and immobilization. Compared with the established amino modified oligonucleotides, hydrazides show enhanced reactivity at neutral and acidic buffer conditions. One method to introduce hydrazides is using amidites with preformed, protected hydrazides. A completely novel approach is the generation of the hydrazide functionality during the oligonucleotide cleavage and deprotection with hydrazine. Therefore, building blocks for the introduction of esters as hydrazide precursors are described. For the enhanced attachment on surfaces branched modifier amidites, which introduce up to four reactive groups to the oligonucleotide, are applied. The efficiency of branched hydrazide oligonucleotides compared with standard amino modified oligonucleotides for the immobilization of DNA on active electronic Nanogen chips is demonstrated.
