ABSTRACT
It was the aim of our investigations to increase the antitumor activity of cyclophosphamide. Therefore we applied a combined treatment with silatranes and isoniazid in relation 1:20:1. The effects were directed against a transplantable sarcoma 180. The parablastomatous invasive zone and the regional lymph nodes draining an implanted tumor were taken for the histochemical and morphological studies. The doses ranged from 50 to 175 mg of body mass. The combined derivatives inhibited tumor growth by 70% in relation to the control. The authors connect the limitation of tumor progression in the applied experimental model in mice with the active response of T dependent zone of the regional lymph nodes, the rebuilding of stroma within the borderline invasive zone and the changes within the composition of cellular immune response of the peritumor tissue.
Subject(s)
Bridged Bicyclo Compounds, Heterocyclic , Bridged Bicyclo Compounds/therapeutic use , Bridged-Ring Compounds/therapeutic use , Cyclophosphamide/therapeutic use , Isoniazid/therapeutic use , Organosilicon Compounds , Sarcoma 180/drug therapy , Silicon/therapeutic use , Animals , Bridged Bicyclo Compounds/administration & dosage , Cyclophosphamide/administration & dosage , Drug Combinations , Female , Isoniazid/administration & dosage , Lymph Nodes/pathology , Male , Mice , Mice, Inbred BALB C , Neoplasm Invasiveness , Sarcoma 180/pathology , Silicon/administration & dosageSubject(s)
Enzyme Induction/drug effects , Enzyme Inhibitors , Polycyclic Compounds/pharmacology , Animals , Azo Compounds/metabolism , Chemical Phenomena , Chemistry, Physical , Methionine/metabolism , Molecular Conformation , Mutagens , Oxidoreductases, N-Demethylating/metabolism , Paralysis/chemically induced , RNA, Transfer/metabolism , Structure-Activity Relationship , Zoxazolamine/toxicityABSTRACT
The thermal decomposition of 31 drugs containing sulphonamides, antituberculous agents, dyes, an oxidant, carboxylic acid derivatives and formaldehyde, expectorants and codeine phosphate has been studied by differential thermal analysis (DTA) and thermogravimetry (TG). The DTA, TG and differential TG curves have been used for identification of the drugs and their qualitative and quantitative analysis. The results for 18 of the drugs were in good agreement with those calculated from the formulation.
